PMID- 35906783
OWN - NLM
STAT- MEDLINE
DCOM- 20221004
LR  - 20221004
IS  - 1756-185X (Electronic)
IS  - 1756-1841 (Linking)
VI  - 25
IP  - 10
DP  - 2022 Oct
TI  - Identification of symptom clusters in patients with ankylosing spondylitis.
PG  - 1137-1144
LID - 10.1111/1756-185X.14391 [doi]
AB  - Symptom cluster refers to a group of 3 or more related symptoms that occur 
      together. Our objectives were to: (1) investigate the frequency, severity and 
      gender difference of symptoms in patients with ankylosing spondylitis (AS); and 
      (2) identify symptom clusters in AS patients. A cross-sectional 
      questionnaire-based survey was conducted using the Patient Health Questionnaire 
      Symptoms Group combined with self-designed variables. Demographic and symptom 
      variables between male and female patients in terms of C-reactive protein (CRP) 
      and human leukocyte antigen (HLA)-B27 status were analyzed with 2-tailed 
      independent t test for continuous variables and Chi-square or Fisher's exact test 
      for categorical variables. Symptom clusters were extracted and analyzed by 
      principal component analysis. There were 122 AS patients included in the study. 
      The most severe symptoms included severe back pain, extremity or joint pain, 
      difficulty in breathing, constipation, intestine discomfort and diarrhea. 
      Stomachache was more prevalent in male patients in which odds ratio was 4.60 (CI 
      1.59-12.97) (P = .006). Patients with HLA-B27 negativity or a higher CRP value 
      were more likely to have dry mouth. Four symptom clusters were classified, which 
      explained 58.4% of the total variation. They were named as the 
      gastrointestinal-cardiac cluster, the fatigue-sleep disturbance cluster, the 
      headache-chest pain cluster, and the mouth-eye cluster. The symptoms appeared to 
      cluster into 4 groups in AS patients, which should be noticed in clinical care.
CI  - (c) 2022 Asia Pacific League of Associations for Rheumatology and John Wiley & Sons 
      Australia, Ltd.
FAU - Yang, Wen
AU  - Yang W
AD  - Department of Rheumatology and Immunology, Third Affiliated Hospital of Sun 
      Yat-Sen University, Guangzhou, China.
FAU - Rong, Li
AU  - Rong L
AD  - Department of Internal Medicine, Third Affiliated Hospital of Sun Yat-Sen 
      University, Guangzhou, China.
FAU - Xu, Quan
AU  - Xu Q
AD  - Department of Rheumatology and Immunology, Third Affiliated Hospital of Sun 
      Yat-Sen University, Guangzhou, China.
FAU - Fu, Xiaoli
AU  - Fu X
AD  - Department of Rheumatology and Immunology, Third Affiliated Hospital of Sun 
      Yat-Sen University, Guangzhou, China.
FAU - Deng, Xiaohong
AU  - Deng X
AD  - Department of Nursing, Third Affiliated Hospital of Sun Yat-Sen University, 
      Guangzhou, China.
FAU - Hu, Ailing
AU  - Hu A
AD  - Department of Nursing, Third Affiliated Hospital of Sun Yat-Sen University, 
      Guangzhou, China.
FAU - Jiang, Yutong
AU  - Jiang Y
AUID- ORCID: 0000-0001-6558-4201
AD  - Department of Rheumatology and Immunology, Third Affiliated Hospital of Sun 
      Yat-Sen University, Guangzhou, China.
LA  - eng
GR  - 2021A1515111172/Guangdong Provincial Basic and Applied Basic Research Fund 
      Project/
GR  - N2017Y09/Nurturing funds for nursing young talents of Sun Yat-sen University/
GR  - 202102020150/Scientific and Technological Planning Project of Guangzhou City/
GR  - 2022GZRPYQN01/Third Affiliated Hospital of Sun Yat-Sen University Cultivating 
      Special Fund Project for the National Natural Science Foundation of China/
GR  - National Natural Science Foundation of China/
GR  - Sun Yat-Sen University/
PT  - Journal Article
DEP - 20220729
PL  - England
TA  - Int J Rheum Dis
JT  - International journal of rheumatic diseases
JID - 101474930
RN  - 0 (HLA-B27 Antigen)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - C-Reactive Protein
MH  - Cross-Sectional Studies
MH  - Female
MH  - HLA-B27 Antigen
MH  - Humans
MH  - Male
MH  - Severity of Illness Index
MH  - *Spondylitis, Ankylosing/diagnosis/epidemiology
MH  - Syndrome
OTO - NOTNLM
OT  - ankylosing spondylitis
OT  - chronic disease
OT  - pain
OT  - symptom assessment
OT  - symptom cluster
EDAT- 2022/07/31 06:00
MHDA- 2022/10/05 06:00
CRDT- 2022/07/30 02:22
PHST- 2022/06/04 00:00 [revised]
PHST- 2022/04/26 00:00 [received]
PHST- 2022/07/03 00:00 [accepted]
PHST- 2022/07/31 06:00 [pubmed]
PHST- 2022/10/05 06:00 [medline]
PHST- 2022/07/30 02:22 [entrez]
AID - 10.1111/1756-185X.14391 [doi]
PST - ppublish
SO  - Int J Rheum Dis. 2022 Oct;25(10):1137-1144. doi: 10.1111/1756-185X.14391. Epub 
      2022 Jul 29.