PMID- 35907172
OWN - NLM
STAT- MEDLINE
DCOM- 20220802
LR  - 20220802
IS  - 1993-0402 (Electronic)
IS  - 1672-0415 (Linking)
VI  - 28
IP  - 8
DP  - 2022 Aug
TI  - Anti-inflammatory Effects of Ampelopsis Japonica Root on Contact Dermatitis in 
      Mice.
PG  - 719-724
LID - 10.1007/s11655-022-3517-0 [doi]
AB  - OBJECTIVE: To investigate the anti-inflammatory potential of Ampelopsis japonica 
      on contact dermatitis (CD). METHODS: A total of 38 Balb/c mice were divided into 
      5 groups by using a random number table: normal mice (n=6), CD model mice (n=8), 
      CD mice treated with 3 or 30 mg/kg of the ethanol extract of A. japonica (EEAJ, 
      n=8) and 7.5 mg/kg dexamethasone treated CD mice (DEX, n=8). CD was induced using 
      topical application of 1-fluoro-2,4-dinitrofluorobenzene in mice. EEAJ and DEX 
      were topically applied to the shaved skin of each mouse for 6 days, and the 
      effects of EEAJ and DEX on skin lesions and color, histopathological 
      abnormalities such as epidermal hyperplasia and immune cell infiltration, and 
      tumor necrosis factor (TNF)-alpha, interleukin-6 (IL-6), and monocyte chemoattractant 
      protein-1 (MCP-1) production were investigated. The effects on changes in body 
      weights and spleen/body weight ratio were also investigated. RESULTS: EEAJ at 30 
      mg/kg significantly prevented scaling, erythema and enlargement of skin weight 
      compared to using carbon dioxide. EEAJ also prevented epithelial hyperplasia and 
      immune cell infiltrations induced by repeated application of DNFB (P<0.01). In 
      addition, EEAJ significantly lowered levels of TNF-alpha, IL-6 and MCP-1 (P<0.05 or 
      P<0.01). The anti-inflammatory effects of EEAJ were similar to those of DEX. 
      CONCLUSION: A. japonica may be a new therapeutic agent with the potential to 
      reduce or replace corticosteroids and its mechanisms are closely related to 
      regulation of TNF-alpha production.
CI  - (c) 2022. The Chinese Journal of Integrated Traditional and Western Medicine Press 
      and Springer-Verlag GmbH Germany, part of Springer Nature.
FAU - Oh, Yoona
AU  - Oh Y
AD  - Division of Pharmacology, School of Korean Medicine, Pusan National University, 
      Gyeongnam, 50612, South Korea.
FAU - Lee, Hongbum
AU  - Lee H
AD  - Division of Pharmacology, School of Korean Medicine, Pusan National University, 
      Gyeongnam, 50612, South Korea.
FAU - Yang, Beodeul
AU  - Yang B
AD  - Division of Pharmacology, School of Korean Medicine, Pusan National University, 
      Gyeongnam, 50612, South Korea.
FAU - Kim, Sura
AU  - Kim S
AD  - Division of Pharmacology, School of Korean Medicine, Pusan National University, 
      Gyeongnam, 50612, South Korea.
FAU - Jeong, Hyunwoo
AU  - Jeong H
AD  - Department of Pathology, College of Korean Medicine, Dongshin University, 
      Jeonnam, 58245, South Korea.
FAU - Kim, Hyungwoo
AU  - Kim H
AD  - Division of Pharmacology, School of Korean Medicine, Pusan National University, 
      Gyeongnam, 50612, South Korea. kronos7@pusan.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20220730
PL  - China
TA  - Chin J Integr Med
JT  - Chinese journal of integrative medicine
JID - 101181180
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Cytokines)
RN  - 0 (Interleukin-6)
RN  - 0 (Plant Extracts)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - D241E059U6 (Dinitrofluorobenzene)
SB  - IM
MH  - *Ampelopsis
MH  - Animals
MH  - Anti-Inflammatory Agents/pharmacology/therapeutic use
MH  - Cytokines
MH  - *Dermatitis, Contact/drug therapy/pathology
MH  - Dinitrofluorobenzene/therapeutic use
MH  - Hyperplasia/drug therapy
MH  - Interleukin-6
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Plant Extracts/pharmacology/therapeutic use
MH  - Tumor Necrosis Factor-alpha
OTO - NOTNLM
OT  - Ampelopsis japonica
OT  - Chinese medicine
OT  - contact dermatitis
OT  - dermatosis
OT  - inflammation
EDAT- 2022/07/31 06:00
MHDA- 2022/08/03 06:00
CRDT- 2022/07/30 11:20
PHST- 2021/09/01 00:00 [accepted]
PHST- 2022/07/30 11:20 [entrez]
PHST- 2022/07/31 06:00 [pubmed]
PHST- 2022/08/03 06:00 [medline]
AID - 10.1007/s11655-022-3517-0 [pii]
AID - 10.1007/s11655-022-3517-0 [doi]
PST - ppublish
SO  - Chin J Integr Med. 2022 Aug;28(8):719-724. doi: 10.1007/s11655-022-3517-0. Epub 
      2022 Jul 30.