PMID- 35907508
OWN - NLM
STAT- MEDLINE
DCOM- 20220908
LR  - 20220908
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 190
DP  - 2022 Aug
TI  - Body weight variability and the risk of dementia in patients with type 2 diabetes 
      mellitus: A nationwide cohort study in Korea.
PG  - 110015
LID - S0168-8227(22)00829-4 [pii]
LID - 10.1016/j.diabres.2022.110015 [doi]
AB  - AIMS: This study aimed to examine the association between body weight variability 
      and dementia risk using a large-scale cohort data of Korean patients with type 2 
      diabetes mellitus (T2DM). METHODS: A population-based cohort of 1,206,764 
      individuals with T2DM aged >/= 40 years who underwent >/= 3 Korean national health 
      screenings were followed up until the end of 2019. Body weight variability was 
      assessed using variability independent of the mean (VIM). A multivariate Cox 
      proportional hazard regression was performed with calculating hazard ratios (HRs) 
      with 95 % confidence intervals (CIs) of dementia incidence. RESULTS: During a 
      median follow-up of 7.9 years, 162,615 (13.4 %) individuals developed dementia. 
      Individuals with greater body weight variability tended to be associated with 
      higher risk of all types of dementia (P for trend < 0.001). Individuals in the 
      highest quartile of VIM showed 26 % (HR: 1.26, 95 % CI: 1.24-1.28), 33 % (HR: 
      1.33, 95 % CI: 1.30-1.36) and 28 % (HR: 1.28, 95 % CI: 1.23-1.33) higher risk for 
      all-cause dementia, Alzheimer's disease, and vascular dementia, compared with 
      those in the lowest quartile. These associations persisted in all body mass index 
      categories (P for trend < 0.001). CONCLUSIONS: Maintaining an appropriate body 
      weight may help mitigate dementia risk in patients with T2DM.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Park, Kye-Yeung
AU  - Park KY
AD  - Department of Family Medicine, Hanyang University College of Medicine, Seoul, 
      South Korea. Electronic address: kyeyeung@naver.com.
FAU - Nam, Ga Eun
AU  - Nam GE
AD  - Department of Family Medicine, Korea University College of Medicine, Seoul, South 
      Korea. Electronic address: namgaaa@daum.net.
FAU - Han, Kyungdo
AU  - Han K
AD  - Department of Statistics and Actuarial Science, Soongsil University, Seoul, South 
      Korea. Electronic address: hkd917@naver.com.
FAU - Hwang, Hwan-Sik
AU  - Hwang HS
AD  - Department of Family Medicine, Hanyang University College of Medicine, Seoul, 
      South Korea. Electronic address: fmhwang@hanyang.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20220728
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
SB  - IM
MH  - *Alzheimer Disease
MH  - Body Weight
MH  - Cohort Studies
MH  - *Diabetes Mellitus, Type 2/complications/epidemiology
MH  - Humans
MH  - Incidence
MH  - Republic of Korea/epidemiology
MH  - Risk Factors
OTO - NOTNLM
OT  - Body weight
OT  - Body weight variability
OT  - Cohort study
OT  - Dementia
OT  - Type 2 diabetes mellitus
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2022/07/31 06:00
MHDA- 2022/09/09 06:00
CRDT- 2022/07/30 19:22
PHST- 2022/03/01 00:00 [received]
PHST- 2022/07/08 00:00 [revised]
PHST- 2022/07/18 00:00 [accepted]
PHST- 2022/07/31 06:00 [pubmed]
PHST- 2022/09/09 06:00 [medline]
PHST- 2022/07/30 19:22 [entrez]
AID - S0168-8227(22)00829-4 [pii]
AID - 10.1016/j.diabres.2022.110015 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2022 Aug;190:110015. doi: 10.1016/j.diabres.2022.110015. 
      Epub 2022 Jul 28.