PMID- 35908853
OWN - NLM
STAT- MEDLINE
DCOM- 20220802
LR  - 20220802
IS  - 1349-3299 (Electronic)
IS  - 1349-2365 (Linking)
VI  - 63
IP  - 4
DP  - 2022
TI  - Bilateral Cardiac Sympathetic Denervation for Treatment-Resistant Ventricular 
      Arrhythmias in Heart Failure Patients with a Reduced Ejection Fraction.
PG  - 692-699
LID - 10.1536/ihj.21-601 [doi]
AB  - The sympathetic nervous system plays an important role in life-threatening 
      ventricular arrhythmias (VAs). Bilateral cardiac sympathetic denervation (BCSD) 
      is performed for refractory VAs. We sought to assess our institutional experience 
      with BCSD in managing treatment-resistant monomorphic ventricular tachycardia 
      (MMVT) in heart failure patients with a reduced ejection fraction (HFrEF).Four 
      patients with HFrEF (EF 30.0 +/- 8.2%, New York Heart Association [NYHA] class IV 
      1) underwent BCSD for MMVT (VT storm 3, repetitive VT requiring implantable 
      cardioverter defibrillator [ICD] therapy 1) refractory to antiarrhythmic drugs, 
      catheter ablation and ICD therapy. BCSD was effective for suppressing VT in 3 
      patients for whom deep sedation was effective for suppressing VT. One patient 
      remained alive after 14 months of follow-up without episodes of VT. One patient 
      died of acute myocardial infarction before discharge and 1 patient died from 
      unknown cause at 3 days post-discharge. In contrast, BCSD was completely 
      ineffective for suppressing VT in a patient with NYHA class IV for whom deep 
      sedation and stellate ganglion block were ineffective. This patient died on the 
      10th post-CSD day, despite left ventricular assist device implantation. In all 
      cases, BCSD was successfully performed without procedure-related 
      complications.Despite the limited number of cases, our results showed that BCSD 
      in patients with HFrEF suppressed refractory MMVT in acute-phase except for a 
      patient with NYHA class IV; however, the prognoses were not good. BCSD may be a 
      treatment option at an earlier stage of NYHA and a bridge to orthotopic heart 
      transplantation, even if BCSD is effective for suppressing VAs.
FAU - Miki, Yuko
AU  - Miki Y
AD  - Division of Cardiology, Gunma Prefectural Cardiovascular Center.
FAU - Yoshimura, Shingo
AU  - Yoshimura S
AD  - Division of Cardiology, Gunma Prefectural Cardiovascular Center.
FAU - Sasaki, Takehito
AU  - Sasaki T
AD  - Division of Cardiology, Gunma Prefectural Cardiovascular Center.
FAU - Takizawa, Ryoya
AU  - Takizawa R
AD  - Division of Cardiology, Gunma Prefectural Cardiovascular Center.
FAU - Kimura, Kohki
AU  - Kimura K
AD  - Division of Cardiology, Gunma Prefectural Cardiovascular Center.
FAU - Haraguchi, Yumiko
AU  - Haraguchi Y
AD  - Division of Cardiology, Gunma Prefectural Cardiovascular Center.
FAU - Sasaki, Wataru
AU  - Sasaki W
AD  - Division of Cardiology, Gunma Prefectural Cardiovascular Center.
FAU - Kishi, Shohei
AU  - Kishi S
AD  - Division of Cardiology, Gunma Prefectural Cardiovascular Center.
FAU - Nakatani, Yosuke
AU  - Nakatani Y
AD  - Division of Cardiology, Gunma Prefectural Cardiovascular Center.
FAU - Kaseno, Kenichi
AU  - Kaseno K
AD  - Division of Cardiology, Gunma Prefectural Cardiovascular Center.
FAU - Goto, Koji
AU  - Goto K
AD  - Division of Cardiology, Gunma Prefectural Cardiovascular Center.
FAU - Take, Yutaka
AU  - Take Y
AD  - Division of Cardiology, Gunma Prefectural Cardiovascular Center.
FAU - Nakamura, Kohki
AU  - Nakamura K
AD  - Division of Cardiology, Gunma Prefectural Cardiovascular Center.
FAU - Niwamae, Nogiku
AU  - Niwamae N
AD  - Department of Cardiovascular Medicine, Japanese Red Cross Maebashi Hospital.
FAU - Kamiyoshihara, Mitsuhiro
AU  - Kamiyoshihara M
AD  - Department of General Thoracic Surgery, Japanese Red Cross Maebashi Hospital.
FAU - Naito, Shigeto
AU  - Naito S
AD  - Division of Cardiology, Gunma Prefectural Cardiovascular Center.
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Int Heart J
JT  - International heart journal
JID - 101244240
SB  - IM
MH  - Aftercare
MH  - Arrhythmias, Cardiac/complications
MH  - *Catheter Ablation/methods
MH  - *Defibrillators, Implantable/adverse effects
MH  - *Heart Failure/complications/surgery
MH  - Humans
MH  - Patient Discharge
MH  - Stroke Volume
MH  - Sympathectomy/methods
MH  - *Tachycardia, Ventricular
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Electrical storm
OT  - Heart failure with reduced ejection fraction
OT  - Refractory ventricular arrhythmia
OT  - Ventricular tachycardia
EDAT- 2022/08/01 06:00
MHDA- 2022/08/03 06:00
CRDT- 2022/07/31 21:42
PHST- 2022/07/31 21:42 [entrez]
PHST- 2022/08/01 06:00 [pubmed]
PHST- 2022/08/03 06:00 [medline]
AID - 10.1536/ihj.21-601 [doi]
PST - ppublish
SO  - Int Heart J. 2022;63(4):692-699. doi: 10.1536/ihj.21-601.