PMID- 35909021
OWN - NLM
STAT- MEDLINE
DCOM- 20220916
LR  - 20221109
IS  - 1879-307X (Electronic)
IS  - 1364-6613 (Linking)
VI  - 26
IP  - 10
DP  - 2022 Oct
TI  - Closing the mechanistic gap: the value of microarchitecture in understanding 
      cognitive networks.
PG  - 873-886
LID - S1364-6613(22)00158-9 [pii]
LID - 10.1016/j.tics.2022.07.001 [doi]
AB  - Cognitive neuroscience aims to provide biologically relevant accounts of 
      cognition. Contemporary research linking spatial patterns of neural activity to 
      psychological constructs describes 'where' hypothesised functions occur, but not 
      'how' these regions contribute to cognition. Technological, empirical, and 
      conceptual advances allow this mechanistic gap to be closed by embedding patterns 
      of functional activity in macro- and microscale descriptions of brain 
      organisation. Recent work on the default mode network (DMN) and the multiple 
      demand network (MDN), for example, highlights a microarchitectural landscape that 
      may explain how activity in these networks integrates varied information, thus 
      providing an anatomical foundation that will help to explain how these networks 
      contribute to many different cognitive states. This perspective highlights 
      emerging insights into how microarchitecture can constrain network accounts of 
      human cognition.
CI  - Copyright (c) 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Paquola, Casey
AU  - Paquola C
AD  - Institute of Neuroscience and Medicine (INM-1), Forschungszentrum Julich, Julich, 
      Germany. Electronic address: c.paquola@fz-juelich.de.
FAU - Amunts, Katrin
AU  - Amunts K
AD  - Institute of Neuroscience and Medicine (INM-1), Forschungszentrum Julich, Julich, 
      Germany; Cecile and Oscar Vogt Institute for Brain Research, University Hospital 
      Dusseldorf, Heinrich-Heine-University Dusseldorf, Dusseldorf, Germany.
FAU - Evans, Alan
AU  - Evans A
AD  - McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, 
      McGill University, Montreal, QC, Canada.
FAU - Smallwood, Jonathan
AU  - Smallwood J
AD  - Department of Psychology, Queen's University, Kingston, ON, Canada.
FAU - Bernhardt, Boris
AU  - Bernhardt B
AD  - McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, 
      McGill University, Montreal, QC, Canada. Electronic address: 
      boris.bernhardt@mcgill.ca.
LA  - eng
GR  - FDN-154298/CIHR/Canada
GR  - PJT-174995/CIHR/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20220729
PL  - England
TA  - Trends Cogn Sci
JT  - Trends in cognitive sciences
JID - 9708669
SB  - IM
MH  - Brain
MH  - *Brain Mapping
MH  - Cognition
MH  - Humans
MH  - *Magnetic Resonance Imaging
OTO - NOTNLM
OT  - functional networks
OT  - higher-order cognition
OT  - microcircuits
OT  - microstructure
OT  - multiscale
COIS- Declaration of interests The authors declare no conflicts of interest.
EDAT- 2022/08/01 06:00
MHDA- 2022/09/17 06:00
CRDT- 2022/07/31 22:04
PHST- 2022/03/21 00:00 [received]
PHST- 2022/07/05 00:00 [revised]
PHST- 2022/07/06 00:00 [accepted]
PHST- 2022/08/01 06:00 [pubmed]
PHST- 2022/09/17 06:00 [medline]
PHST- 2022/07/31 22:04 [entrez]
AID - S1364-6613(22)00158-9 [pii]
AID - 10.1016/j.tics.2022.07.001 [doi]
PST - ppublish
SO  - Trends Cogn Sci. 2022 Oct;26(10):873-886. doi: 10.1016/j.tics.2022.07.001. Epub 
      2022 Jul 29.