PMID- 35909222
OWN - NLM
STAT- MEDLINE
DCOM- 20220920
LR  - 20221231
IS  - 1600-065X (Electronic)
IS  - 0105-2896 (Print)
IS  - 0105-2896 (Linking)
VI  - 311
IP  - 1
DP  - 2022 Oct
TI  - Targetability of the neurovascular unit in inflammatory diseases of the central 
      nervous system.
PG  - 39-49
LID - 10.1111/imr.13121 [doi]
AB  - The blood-brain barrier (BBB) is a selectively permeable barrier separating the 
      periphery from the central nervous system (CNS). The BBB restricts the flow of 
      most material into and out of the CNS, including many drugs that could be used as 
      potent therapies. BBB permeability is modulated by several cells that are 
      collectively called the neurovascular unit (NVU). The NVU consists of specialized 
      CNS endothelial cells (ECs), pericytes, astrocytes, microglia, and neurons. CNS 
      ECs maintain a complex "seal" via tight junctions, forming the BBB; breakdown of 
      these tight junctions leads to BBB disruption. Pericytes control the vascular 
      flow within capillaries and help maintain the basal lamina. Astrocytes control 
      much of the flow of material that has moved beyond the CNS EC layer and can form 
      a secondary barrier under inflammatory conditions. Microglia survey the border of 
      the NVU for noxious material. Neuronal activity also plays a role in the 
      maintenance of the BBB. Since astrocytes, pericytes, microglia, and neurons are 
      all able to modulate the permeability of the BBB, understating the complex 
      contributions of each member of the NVU will potentially uncover novel and 
      effective methods for delivery of neurotherapies to the CNS.
CI  - (c) 2022 The Authors. Immunological Reviews published by John Wiley & Sons Ltd.
FAU - Smith, Brandon C
AU  - Smith BC
AD  - Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, 
      Cleveland, Ohio, USA.
AD  - Department of Biological, Geological, and Environmental Sciences, Cleveland State 
      University, Cleveland, Ohio, USA.
FAU - Tinkey, Rachel A
AU  - Tinkey RA
AD  - Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, 
      Cleveland, Ohio, USA.
AD  - School of Biomedical Sciences, Kent State University, Kent, Ohio, USA.
FAU - Shaw, Benjamin C
AU  - Shaw BC
AUID- ORCID: 0000-0001-8862-3840
AD  - Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, 
      Cleveland, Ohio, USA.
FAU - Williams, Jessica L
AU  - Williams JL
AUID- ORCID: 0000-0002-9801-9580
AD  - Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, 
      Cleveland, Ohio, USA.
AD  - Brain Health Research Institute, Kent State University, Kent, Ohio, USA.
LA  - eng
GR  - K00 NS120365/NS/NINDS NIH HHS/United States
GR  - R01 NS119178/NS/NINDS NIH HHS/United States
GR  - T32 HL150389/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20220731
PL  - England
TA  - Immunol Rev
JT  - Immunological reviews
JID - 7702118
SB  - IM
MH  - Astrocytes/metabolism
MH  - Blood-Brain Barrier/physiology
MH  - Central Nervous System
MH  - *Endothelial Cells/physiology
MH  - Humans
MH  - *Pericytes/metabolism
PMC - PMC9489669
MID - NIHMS1826125
OTO - NOTNLM
OT  - blood-brain barrier
OT  - endothelial cell
OT  - glia
OT  - neuroinflammatory disease
OT  - pericyte
OT  - tight junction
COIS- The authors declare no competing financial interests.
EDAT- 2022/08/01 06:00
MHDA- 2022/09/21 06:00
PMCR- 2022/12/28
CRDT- 2022/07/31 23:32
PHST- 2022/08/01 06:00 [pubmed]
PHST- 2022/09/21 06:00 [medline]
PHST- 2022/07/31 23:32 [entrez]
PHST- 2022/12/28 00:00 [pmc-release]
AID - IMR13121 [pii]
AID - 10.1111/imr.13121 [doi]
PST - ppublish
SO  - Immunol Rev. 2022 Oct;311(1):39-49. doi: 10.1111/imr.13121. Epub 2022 Jul 31.