PMID- 35909488
OWN - NLM
STAT- MEDLINE
DCOM- 20220802
LR  - 20240329
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2022
DP  - 2022
TI  - hsa_circ_0084811 Regulates Cell Proliferation and Apoptosis in Retinoblastoma 
      through miR-18a-5p/miR-18b-5p/E2F5 Axis.
PG  - 6918396
LID - 10.1155/2022/6918396 [doi]
LID - 6918396
AB  - BACKGROUND: Retinoblastoma (RB) is the commonest primary intraocular malignancy 
      during childhood. Circular RNAs (circRNAs) act as regulators in RB development, 
      and hsa_circ_E2F5 (circ_0084811 in this study) was found to be highly expressed 
      in RB cells, so we wanted to identify its detailed molecular mechanism. METHODS: 
      The expression level of circ_0084811 in RB cells was tested by RT-qPCR and its 
      effects on RB cells were evaluated through functional assays. The regulatory 
      mechanism that circ_0084811 may exert in RB progression was testified through 
      mechanism experiments. RESULTS: High circ_0084811 expression in RB cells 
      facilitated cell proliferation but inhibited cell apoptosis. The enrichment of 
      acetylation of histone 3 lysine 27 (H3K27ac) in circ_0084811 promoter induced 
      circ_0084811 upregulation. Moreover, circ_0084811 regulated E2F transcription 
      factor 5 (E2F5) expression via sponging microRNA-18a-5p (miR-18a-5p) and 
      microRNA-18b-5p (miR-18b-5p). CONCLUSION: circ_0084811 modulated RB progression 
      via the miR-18a-5p/miR-18b-5p/E2F5 axis.
CI  - Copyright (c) 2022 Guangwei Jiang et al.
FAU - Jiang, Guangwei
AU  - Jiang G
AD  - Department of Ophthalmology, Yantai Affiliated Hospital of Binzhou Medical 
      University, Yantai City, Shandong Province 264100, China.
FAU - Qu, Mingxuan
AU  - Qu M
AD  - Hemodialysis Room, Yantai Affiliated Hospital of Binzhou Medical University, 
      Yantai City, Shandong Province 264100, China.
FAU - Kong, Lili
AU  - Kong L
AD  - Endocrinology & Metabolic Diseases, Yantai Affiliated Hospital of Binzhou Medical 
      University, Yantai City, Shandong Province 264100, China.
FAU - Song, Xiaoming
AU  - Song X
AD  - Endocrinology & Metabolic Diseases, Yantai Affiliated Hospital of Binzhou Medical 
      University, Yantai City, Shandong Province 264100, China.
FAU - Jiang, Shanhao
AU  - Jiang S
AUID- ORCID: 0000-0002-0220-5435
AD  - Department of Ophthalmology, Yantai Affiliated Hospital of Binzhou Medical 
      University, Yantai City, Shandong Province 264100, China.
LA  - eng
PT  - Journal Article
PT  - Retracted Publication
DEP - 20220719
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (E2F5 Transcription Factor)
RN  - 0 (E2F5 protein, human)
RN  - 0 (MIRN18A microRNA, human)
RN  - 0 (MicroRNAs)
SB  - IM
RIN - Biomed Res Int. 2024 Mar 20;2024:9805059. PMID: 38550126
MH  - Apoptosis/genetics
MH  - Cell Line, Tumor
MH  - Cell Movement/physiology
MH  - Cell Proliferation/genetics
MH  - E2F5 Transcription Factor
MH  - Humans
MH  - *MicroRNAs/genetics/metabolism
MH  - *Retinal Neoplasms/genetics
MH  - *Retinoblastoma/genetics
PMC - PMC9325647
COIS- The authors have no conflicts of interest to declare.
EDAT- 2022/08/02 06:00
MHDA- 2022/08/03 06:00
PMCR- 2022/07/19
CRDT- 2022/08/01 03:15
PHST- 2022/04/18 00:00 [received]
PHST- 2022/06/21 00:00 [revised]
PHST- 2022/07/01 00:00 [accepted]
PHST- 2022/08/01 03:15 [entrez]
PHST- 2022/08/02 06:00 [pubmed]
PHST- 2022/08/03 06:00 [medline]
PHST- 2022/07/19 00:00 [pmc-release]
AID - 10.1155/2022/6918396 [doi]
PST - epublish
SO  - Biomed Res Int. 2022 Jul 19;2022:6918396. doi: 10.1155/2022/6918396. eCollection 
      2022.