PMID- 35909561 OWN - NLM STAT- MEDLINE DCOM- 20220802 LR - 20220802 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 13 DP - 2022 TI - Sex-Specific Associations Between Low Muscle Mass and Glucose Fluctuations in Patients With Type 2 Diabetes Mellitus. PG - 913207 LID - 10.3389/fendo.2022.913207 [doi] LID - 913207 AB - OBJECTIVE: Studies have shown that sex differences in lean mass, concentrations of sex hormones, and lifestyles influence cle health and glucose metabolism. We evaluated the sex-specific association between low muscle mass and glucose fluctuations in hospitalized patients with type 2 diabetes mellitus (T2DM) receiving continuous subcutaneous insulin infusion (CSII) therapy. METHODS: A total of 1084 participants were included. Body composition was determined by dual-energy X-ray absorptiometry. Intraday blood glucose fluctuation was estimated by the Largest amplitude of glycemic excursions (LAGE) and standard deviation of blood glucose (SDBG). RESULTS: The prevalence of low muscle mass was higher in males than in females (p<0.001). There was a significant sex-specific interaction between the status of low muscle mass and glucose fluctuations (LAGE and SDBG) (p for interaction=0.025 and 0.036 for SDBG and LAGE, respectively). Among males, low muscle mass was significantly associated with a higher LAGE and SDBG (difference in LAGE: 2.26 [95% CI: 1.01 to 3.51], p < 0.001; difference in SDBG: 0.45 [95% CI: 0.25 to 0.65], p < 0.001) after adjustment for HbA1c, diabetes duration, hyperlipidemia, diabetic peripheral neuropathy, diabetic nephropathy, and cardiovascular disease. These associations remained significant after further adjustment for age and C-peptide. Among females, low muscle mass was not associated with LAGE or SDBG after adjustment for all covariates. CONCLUSION: The prevalence of low muscle mass was higher in males than in females. Low muscle mass was significantly associated with higher LAGE and SDBG among males, but not females. CI - Copyright (c) 2022 Shi, Liu, Zhang, Xiao, Huang, Yan, Zhang, Su, Jiang, Lin, Liu and Li. FAU - Shi, Xiulin AU - Shi X AD - Department of Endocrinology and Diabetes, Xiamen Diabetes Institute, Fujian Province Key Laboratory of Translational Research for Diabetes, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China. AD - The School of Clinical Medicine, Fujian Medical University, Fouzhou, China. FAU - Liu, Wenjuan AU - Liu W AD - Department of Endocrine, Zhangzhou Hospital of Traditional Chinese Medicine, Zhangzhou, China. FAU - Zhang, Lulu AU - Zhang L AD - Department of Endocrinology and Diabetes, Xiamen Diabetes Institute, Fujian Province Key Laboratory of Translational Research for Diabetes, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China. FAU - Xiao, Fangsen AU - Xiao F AD - Department of Endocrinology and Diabetes, Xiamen Diabetes Institute, Fujian Province Key Laboratory of Translational Research for Diabetes, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China. FAU - Huang, Peiying AU - Huang P AD - Department of Endocrinology and Diabetes, Xiamen Diabetes Institute, Fujian Province Key Laboratory of Translational Research for Diabetes, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China. FAU - Yan, Bing AU - Yan B AD - Department of Endocrinology and Diabetes, Xiamen Diabetes Institute, Fujian Province Key Laboratory of Translational Research for Diabetes, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China. FAU - Zhang, Yiping AU - Zhang Y AD - The School of Clinical Medicine, Fujian Medical University, Fouzhou, China. FAU - Su, Weijuan AU - Su W AD - Department of Endocrinology and Diabetes, Xiamen Diabetes Institute, Fujian Province Key Laboratory of Translational Research for Diabetes, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China. FAU - Jiang, Qiuhui AU - Jiang Q AD - The School of Clinical Medicine, Fujian Medical University, Fouzhou, China. FAU - Lin, Mingzhu AU - Lin M AD - Department of Endocrinology and Diabetes, Xiamen Diabetes Institute, Fujian Province Key Laboratory of Translational Research for Diabetes, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China. FAU - Liu, Wei AU - Liu W AD - Department of Endocrinology and Diabetes, Xiamen Diabetes Institute, Fujian Province Key Laboratory of Translational Research for Diabetes, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China. FAU - Li, Xuejun AU - Li X AD - Department of Endocrinology and Diabetes, Xiamen Diabetes Institute, Fujian Province Key Laboratory of Translational Research for Diabetes, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China. AD - The School of Clinical Medicine, Fujian Medical University, Fouzhou, China. LA - eng PT - Journal Article PT - Research Support, U.S. Gov't, Non-P.H.S. DEP - 20220713 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 RN - 0 (Blood Glucose) RN - 0 (Insulin) RN - IY9XDZ35W2 (Glucose) SB - IM MH - Blood Glucose/metabolism MH - *Diabetes Mellitus, Type 2/epidemiology MH - Female MH - Glucose MH - Humans MH - Insulin MH - Male MH - Muscles PMC - PMC9326160 OTO - NOTNLM OT - continuous subcutaneous insulin infusion OT - glucose fluctuations OT - low muscle mass OT - sex-specific OT - type 2 diabetes mellitus COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2022/08/02 06:00 MHDA- 2022/08/03 06:00 PMCR- 2022/01/01 CRDT- 2022/08/01 03:16 PHST- 2022/04/05 00:00 [received] PHST- 2022/06/16 00:00 [accepted] PHST- 2022/08/01 03:16 [entrez] PHST- 2022/08/02 06:00 [pubmed] PHST- 2022/08/03 06:00 [medline] PHST- 2022/01/01 00:00 [pmc-release] AID - 10.3389/fendo.2022.913207 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2022 Jul 13;13:913207. doi: 10.3389/fendo.2022.913207. eCollection 2022.