PMID- 35909680
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231023
IS  - 2297-1769 (Print)
IS  - 2297-1769 (Electronic)
IS  - 2297-1769 (Linking)
VI  - 9
DP  - 2022
TI  - Polyunsaturated Fatty Acid EAB-277((R)) Supplementation Improved Heart Rate 
      Variability and Clinical Signs in Tracheal Collapse Dogs.
PG  - 880952
LID - 10.3389/fvets.2022.880952 [doi]
LID - 880952
AB  - Canine tracheal collapse is a progressive disease in small breed dogs resulting 
      from chronic inflammation of the tracheal mucosal lining. Polyunsaturated fatty 
      acid EAB-277((R)) is one of the nutraceuticals that can alleviate inflammation and 
      oxidative stress. Heart rate variability (HRV) is a prognostic tool related to 
      sympathovagal balance and oxidative stress level, which is widely used with 
      cardiorespiratory diseases. However, the effect of EAB-277((R)) on HRV in tracheal 
      collapse dogs has rarely been investigated. In this study, 26 tracheal collapse 
      dogs were divided into two groups. In the control group, the dogs received the 
      standard treatment, whereas the dogs in the EAB-277((R)) group received standard 
      treatment combined with EAB-277((R)). After being treated for 5 weeks, changes in 
      radiographic findings, blood profiles, serum malondialdehyde, inflammatory 
      markers, and HRV were evaluated. This study found that clinical signs were 
      improved in both groups (p < 0.05). However, serum malondialdehyde (MDA), 
      Interleukin-6 (IL-6), and Tumor necrosis factor-alpha (TNF-alpha) were decreased only 
      in the EAB-277((R)) group after treatment for five weeks (p < 0.05) and the mean 
      percent change of MDA, IL-6, and TNF-alpha at week five compared to baseline in the 
      EAB-277((R)) group was greater than in the control group (p < 0.05). Additionally, 
      greater sympathovagal imbalance indicated by decreased standard deviation of all 
      normal R-R intervals (SDNN) and standard deviation of the averaged R-R intervals 
      for all 5-minutes segments (SDANN) was found in the control group at week five 
      compared to baseline (P < 0.05), whereas EAB-277((R)) improved SDNN and SDANN and 
      decreased low frequency/high-frequency component (LF/HF ratio) after being 
      treated for five weeks (P < 0.05). This study demonstrates that EAB-277((R)) 
      improves clinical signs and attenuates HRV impairment by reducing oxidative 
      stress and inflammation in tracheal collapse dogs.
CI  - Copyright (c) 2022 Mektrirat, Rueangsri, Keeratichandacha, Soonsawat, Boonyapakorn 
      and Pongkan.
FAU - Mektrirat, Raktham
AU  - Mektrirat R
AD  - Department of Veterinary Biosciences and Veterinary Public Health, Faculty of 
      Veterinary Medicine, Chiang Mai University, Chiang Mai, Thailand.
AD  - Integrative Research Center for Veterinary Circulatory Sciences, Faculty of 
      Veterinary Medicine, Chiang Mai University, Chiang Mai, Thailand.
FAU - Rueangsri, Thareerat
AU  - Rueangsri T
AD  - Department of Veterinary Biosciences and Veterinary Public Health, Faculty of 
      Veterinary Medicine, Chiang Mai University, Chiang Mai, Thailand.
FAU - Keeratichandacha, Waraporn
AU  - Keeratichandacha W
AD  - Department of Veterinary Biosciences and Veterinary Public Health, Faculty of 
      Veterinary Medicine, Chiang Mai University, Chiang Mai, Thailand.
FAU - Soonsawat, Sasiwimon
AU  - Soonsawat S
AD  - Veterinary Diagnostic Laboratory, Faculty of Veterinary Medicine, Chiang Mai 
      University, Chiang Mai, Thailand.
FAU - Boonyapakorn, Chavalit
AU  - Boonyapakorn C
AD  - Integrative Research Center for Veterinary Circulatory Sciences, Faculty of 
      Veterinary Medicine, Chiang Mai University, Chiang Mai, Thailand.
AD  - Department of Companion Animal and Wildlife Clinic, Faculty of Veterinary 
      Medicine, Chiang Mai University, Chiang Mai, Thailand.
AD  - Veterinary Cardiopulmonary Clinic, Small Animal Hospital, Faculty of Veterinary 
      Medicine, Chiang Mai University, Chiang Mai, Thailand.
FAU - Pongkan, Wanpitak
AU  - Pongkan W
AD  - Department of Veterinary Biosciences and Veterinary Public Health, Faculty of 
      Veterinary Medicine, Chiang Mai University, Chiang Mai, Thailand.
AD  - Integrative Research Center for Veterinary Circulatory Sciences, Faculty of 
      Veterinary Medicine, Chiang Mai University, Chiang Mai, Thailand.
AD  - Veterinary Cardiopulmonary Clinic, Small Animal Hospital, Faculty of Veterinary 
      Medicine, Chiang Mai University, Chiang Mai, Thailand.
AD  - Center of Excellence in Veterinary Biosciences, Faculty of Veterinary Medicine, 
      Chiang Mai University, Chiang Mai, Thailand.
LA  - eng
PT  - Journal Article
DEP - 20220714
PL  - Switzerland
TA  - Front Vet Sci
JT  - Frontiers in veterinary science
JID - 101666658
EIN - Front Vet Sci. 2023 Oct 05;10:1296087. PMID: 37869500
PMC - PMC9330478
OTO - NOTNLM
OT  - dog
OT  - heart rate variability
OT  - inflammatory marker
OT  - malondialdehyde
OT  - polyunsaturated fatty acid EAB-277(R)
OT  - tracheal collapse
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/08/02 06:00
MHDA- 2022/08/02 06:01
PMCR- 2022/01/01
CRDT- 2022/08/01 03:18
PHST- 2022/02/22 00:00 [received]
PHST- 2022/06/15 00:00 [accepted]
PHST- 2022/08/01 03:18 [entrez]
PHST- 2022/08/02 06:00 [pubmed]
PHST- 2022/08/02 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fvets.2022.880952 [doi]
PST - epublish
SO  - Front Vet Sci. 2022 Jul 14;9:880952. doi: 10.3389/fvets.2022.880952. eCollection 
      2022.