PMID- 35910213
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220802
IS  - 1664-8021 (Print)
IS  - 1664-8021 (Electronic)
IS  - 1664-8021 (Linking)
VI  - 13
DP  - 2022
TI  - Smoking patients with laryngeal cancer screened with a novel immunogenomics-based 
      prognostic signature.
PG  - 961764
LID - 10.3389/fgene.2022.961764 [doi]
LID - 961764
AB  - The immune system greatly affects the prognosis of various malignancies. Studies 
      on differentially expressed immune-related genes (IRGs) in the immune 
      microenvironment of laryngeal squamous cell carcinoma (LSCC) have rarely been 
      reported. In this paper, the prognostic potentials of IRGs were explored in LSCC 
      patients with smoking use. The RNA-seq data containing IRGs and corresponding 
      clinical information of smoking LSCC patients was obtained from The Cancer Genome 
      Atlas (TCGA). Differentially expressed IRGs were identified and functional 
      enrichment analysis was used to reveal the pathway of IRGs. Then, IRGs with 
      prognostic potentials in smoking LSCC patients were screened out by univariate 
      Cox regression analysis. Finally, multivariate Cox regression analysis was 
      conducted to assess the prognostic signature of 5 IRGs after adjustment of 
      clinical factors and patients were classified into two subgroups based on 
      different IRGs expression. The prognostic capacity of the model was verified by 
      another independent cohort from Gene Expression Omnibus (GEO) database. Nomogram 
      including the prognostic signature was established and shown some clinical net 
      benefit. These findings may contribute to the development of potential 
      therapeutic targets and biomarkers for the new-immunotherapy of LSCC patients 
      with smoking use.
CI  - Copyright (c) 2022 Shen, Zhou, Dong, Dong and Zhang.
FAU - Shen, Yujie
AU  - Shen Y
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Eye, Ear, Nose and 
      Throat Hospital, Fudan University, Shanghai, China.
FAU - Zhou, Han
AU  - Zhou H
AD  - Department of Otorhinolaryngology, The First Affiliated Hospital of Nanjing 
      Medical University, Nanjing, China.
FAU - Dong, Shikun
AU  - Dong S
AD  - Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, Southeast 
      University, Nanjing, China.
FAU - Dong, Weida
AU  - Dong W
AD  - Department of Otorhinolaryngology, The First Affiliated Hospital of Nanjing 
      Medical University, Nanjing, China.
FAU - Zhang, Liqing
AU  - Zhang L
AD  - Department of Otorhinolaryngology, The First Affiliated Hospital of Nanjing 
      Medical University, Nanjing, China.
LA  - eng
PT  - Journal Article
DEP - 20220714
PL  - Switzerland
TA  - Front Genet
JT  - Frontiers in genetics
JID - 101560621
PMC - PMC9333188
OTO - NOTNLM
OT  - Lscc
OT  - TCGA
OT  - outcome
OT  - prognosis
OT  - signature
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/08/02 06:00
MHDA- 2022/08/02 06:01
PMCR- 2022/07/14
CRDT- 2022/08/01 03:26
PHST- 2022/06/05 00:00 [received]
PHST- 2022/06/28 00:00 [accepted]
PHST- 2022/08/01 03:26 [entrez]
PHST- 2022/08/02 06:00 [pubmed]
PHST- 2022/08/02 06:01 [medline]
PHST- 2022/07/14 00:00 [pmc-release]
AID - 961764 [pii]
AID - 10.3389/fgene.2022.961764 [doi]
PST - epublish
SO  - Front Genet. 2022 Jul 14;13:961764. doi: 10.3389/fgene.2022.961764. eCollection 
      2022.