PMID- 35911095
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220802
IS  - 2296-861X (Print)
IS  - 2296-861X (Electronic)
IS  - 2296-861X (Linking)
VI  - 9
DP  - 2022
TI  - Correlations Between Iron Status and Body Composition in Patients With Type 2 
      Diabetes Mellitus.
PG  - 911860
LID - 10.3389/fnut.2022.911860 [doi]
LID - 911860
AB  - BACKGROUND: Our study aimed to investigate the association between iron 
      metabolism and body composition in patients with type 2 diabetes mellitus (T2DM). 
      METHODS: A total of 824 patients with T2DM were enrolled. Measurements of body 
      composition were obtained by dual-energy X-ray absorptiometry. Patients were 
      stratified into three groups according to their sex-specific ferritin levels. 
      Basic information, laboratory results, and body composition were collected. 
      RESULTS: Serum iron and transferrin saturation (TSAT) were increased 
      significantly with increased serum ferritin (all p < 0.05). Total iron-binding 
      capacity (TIBC) was decreased significantly with increased serum ferritin (p < 
      0.05). Visceral fat mass (VF), android fat/total body fat mass, android-to-gynoid 
      fat ratio (A/G ratio), and high-sensitivity C-reactive protein were all increased 
      significantly with increased serum ferritin (all p < 0.05). Patients with a high 
      A/G ratio (A/G ratio >== 1) had significantly higher serum iron, ferritin, and 
      TSAT, but significantly lower TIBC. In the model adjusted for age and gender, 
      higher ferritin levels were associated with a higher VF (all p < 0.05). Serum 
      iron was positively correlated with the occurrence of a high A/G ratio (A/G ratio 
      >== 1) after the adjustment of confounding factors [an odds ratio (OR = 1.09, 95% 
      CI, 1.02-1.19, p = 0.02)]. With receiver operating curve analysis, the cutoff 
      value of serum iron for a high A/G ratio was 18.56, and the area under the curve 
      was 0.771 (sensitivity 88.9%and specificity 63.9%, p = 0.01). CONCLUSION: Higher 
      serum iron and ferritin concentrations were positively associated with a higher 
      VF. Higher serum iron concentrations were positively correlated with a high A/G 
      ratio. This study indicates the potential relationship between iron overload and 
      the body composition in patients with T2DM.
CI  - Copyright (c) 2022 Zimiao, Dongdong, Shuoping, Peng, Fan, Rujun and Xiaohua.
FAU - Zimiao, Chen
AU  - Zimiao C
AD  - Department of Endocrinology and Metabolism, The First Affiliated Hospital of 
      Wenzhou Medical University, Wenzhou, China.
FAU - Dongdong, Luo
AU  - Dongdong L
AD  - Department of Endocrinology and Metabolism, The Second Affiliated Hospital of 
      Dalian Medical University, Dalian Medical University, Dalian, China.
FAU - Shuoping, Chen
AU  - Shuoping C
AD  - Department of Endocrinology and Metabolism, The First Affiliated Hospital of 
      Wenzhou Medical University, Wenzhou, China.
FAU - Peng, Zhou
AU  - Peng Z
AD  - Central Hospital of Qiaoxia Town, Wenzhou, China.
FAU - Fan, Zheng
AU  - Fan Z
AD  - College of Psychiatry, Wenzhou Medical University, Wenzhou, China.
FAU - Rujun, Chen
AU  - Rujun C
AD  - Department of Burn, 906 Hospital of the Joint Logistics Team, PLA, Wenzhou, 
      China.
FAU - Xiaohua, Gong
AU  - Xiaohua G
AD  - Department of Endocrinology and Metabolism, The First Affiliated Hospital of 
      Wenzhou Medical University, Wenzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20220713
PL  - Switzerland
TA  - Front Nutr
JT  - Frontiers in nutrition
JID - 101642264
PMC - PMC9326402
OTO - NOTNLM
OT  - android-to-gynoid fat ratio
OT  - body composition
OT  - iron metabolism
OT  - type 2 diabetes mellitus
OT  - visceral fat mass
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/08/02 06:00
MHDA- 2022/08/02 06:01
PMCR- 2022/01/01
CRDT- 2022/08/01 03:42
PHST- 2022/04/03 00:00 [received]
PHST- 2022/06/22 00:00 [accepted]
PHST- 2022/08/01 03:42 [entrez]
PHST- 2022/08/02 06:00 [pubmed]
PHST- 2022/08/02 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fnut.2022.911860 [doi]
PST - epublish
SO  - Front Nutr. 2022 Jul 13;9:911860. doi: 10.3389/fnut.2022.911860. eCollection 
      2022.