PMID- 35911502 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220802 IS - 1178-7007 (Print) IS - 1178-7007 (Electronic) IS - 1178-7007 (Linking) VI - 15 DP - 2022 TI - Preadmission Insulin-Treated Type 2 Diabetes Mellitus Patients Had Increased Mortality in Intensive Care Units. PG - 2135-2148 LID - 10.2147/DMSO.S369152 [doi] AB - AIM: To explore the clinical outcomes among preadmission insulin-treated type 2 diabetes mellitus (T2DM) in intensive care units (ICU). PATIENTS AND METHODS: In this retrospective observational study, 578 T2DM patients admitted to ICU were recruited from March 2011 to February 2021, which were composed of 528 patients treated with insulin after ICU admission (including 300 preadmission non-insulin-treated and 228 preadmission insulin-treated patients) and 50 patients treated without insulin before and after ICU admission. Clinical outcomes were compared between the groups. Variables of age (+/- 10 years), gender, blood glucose >10 mmol/l on ICU admission, and original comorbidities were used for matching to get the 1:1 matched cohort. The Kaplan-Meier survival curves were graphed to describe the survival trend and Cox regression analysis was performed to get adjusted hazard ratio (HR). RESULTS: Compared with the preadmission non-insulin-treated T2DM patients, preadmission insulin-treated T2DM patients had higher incidence of hypoglycemia [14.5% (33/228) vs 8.7% (26/300); p = 0.036]. In the 1:1 matched cohort, the preadmission insulin-treated T2DM patients had significantly increased mortality rate [30.0% (45/150) vs (16.0% (24/150)); adjusted HR, 1.68 (1.01-2.80)] than preadmission non-insulin-treated T2DM patients. Compared with T2DM patients treated without insulin before and after ICU admission, preadmission insulin-treated T2DM patients had higher mortality and longer length of ICU stay (all p < 0.05). CONCLUSION: Preadmission insulin treatment was associated with increased mortality rate and longer length of ICU stay among T2DM patients in ICU. Preadmission insulin-treated T2DM patients might have worse clinical outcomes when they are critically ill. CI - (c) 2022 Fan et al. FAU - Fan, Rongping AU - Fan R AD - Division of Endocrinology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, People's Republic of China. AD - Branch of National Clinical Research Center for Metabolic Diseases, Wuhan, 430030, People's Republic of China. FAU - Xie, Lei AU - Xie L AD - Division of Endocrinology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, People's Republic of China. AD - Branch of National Clinical Research Center for Metabolic Diseases, Wuhan, 430030, People's Republic of China. FAU - Peng, Xuemin AU - Peng X AD - Division of Endocrinology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, People's Republic of China. AD - Branch of National Clinical Research Center for Metabolic Diseases, Wuhan, 430030, People's Republic of China. FAU - Yu, Bo AU - Yu B AD - Division of Cardiology, Department of Internal Medicine and Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, People's Republic of China. FAU - Zou, Huajie AU - Zou H AD - Division of Endocrinology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, People's Republic of China. AD - Branch of National Clinical Research Center for Metabolic Diseases, Wuhan, 430030, People's Republic of China. AD - Division of Endocrinology, Department of Internal Medicine, The Affiliated Hospital of Qinghai University, Xining, Qinghai, 810001, People's Republic of China. FAU - Huang, Jiaojiao AU - Huang J AD - Division of Endocrinology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, People's Republic of China. AD - Branch of National Clinical Research Center for Metabolic Diseases, Wuhan, 430030, People's Republic of China. FAU - Yu, Xuefeng AU - Yu X AD - Division of Endocrinology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, People's Republic of China. AD - Branch of National Clinical Research Center for Metabolic Diseases, Wuhan, 430030, People's Republic of China. FAU - Wang, Daowen AU - Wang D AD - Division of Cardiology, Department of Internal Medicine and Hubei Key Laboratory of Genetics and Molecular Mechanisms of Cardiological Disorders, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, People's Republic of China. FAU - Yang, Yan AU - Yang Y AUID- ORCID: 0000-0001-8146-8040 AD - Division of Endocrinology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, People's Republic of China. AD - Branch of National Clinical Research Center for Metabolic Diseases, Wuhan, 430030, People's Republic of China. LA - eng PT - Journal Article DEP - 20220722 PL - New Zealand TA - Diabetes Metab Syndr Obes JT - Diabetes, metabolic syndrome and obesity : targets and therapy JID - 101515585 PMC - PMC9325876 OTO - NOTNLM OT - ICU stay OT - insulin treatment OT - intensive care units OT - mortality OT - type 2 diabetes mellitus COIS- All authors declared no conflict of interest. EDAT- 2022/08/02 06:00 MHDA- 2022/08/02 06:01 PMCR- 2022/07/22 CRDT- 2022/08/01 03:46 PHST- 2022/04/08 00:00 [received] PHST- 2022/07/09 00:00 [accepted] PHST- 2022/08/01 03:46 [entrez] PHST- 2022/08/02 06:00 [pubmed] PHST- 2022/08/02 06:01 [medline] PHST- 2022/07/22 00:00 [pmc-release] AID - 369152 [pii] AID - 10.2147/DMSO.S369152 [doi] PST - epublish SO - Diabetes Metab Syndr Obes. 2022 Jul 22;15:2135-2148. doi: 10.2147/DMSO.S369152. eCollection 2022.