PMID- 35912246
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220802
IS  - 2234-943X (Print)
IS  - 2234-943X (Electronic)
IS  - 2234-943X (Linking)
VI  - 12
DP  - 2022
TI  - Pathogens and Pathogenesis in Wheezing Diseases in Children Under 6.
PG  - 922214
LID - 10.3389/fonc.2022.922214 [doi]
LID - 922214
AB  - Few studies have comprehensively assessed the roles of cytokine production in 
      wheezing pathogenesis. Therefore, we undertook this study to determine the 
      association between wheezing episodes and cytokines, and to provide further 
      information on this topic. Firstly, we retrospectively collected I176 children, 
      including 122 subjects with first wheezing and 54 subjects with recurrent 
      wheezing, to analyze the etiology and clinical characteristics of children with 
      wheezing diseases. Then, we collected 52 children with wheezing diseases and 25 
      normal controls to detect the expression of interferon-gamma (IFN-gamma), interleukin-4 
      (IL-4), IFN-gamma/IL-4, IL-17A, IL-17E, IgE, matrix metalloproteinase-3 (MMP-3), and 
      MMP-9 in serum or plasma. The results showed that boys under 3 years old with 
      history of allergies were more likely to develop wheezing diseases. In our 
      cohort, M. pneumoniae caused a greater proportion of wheezing in children than 
      expected. The expression of IgE [18.80 (13.65-31.00) vs. 17.9 (10.15-21.60)], 
      IL-4 [24.00 (24.00-48.00) vs. 23.00 (9.50-27.00)], IFN-gamma [70.59 (41.63-116.46) 
      vs. 49.83 (29.58-81.74)], MMP3 [53.40 (20.02-128.2) vs. 30.90 (13.80-50.95)], 
      MMP9 [148.10 (99.30-276.10) vs. 122.10 (82.20-162.35)], IL-17A [80.55 
      (54.46-113.08) vs. 61.11 (29.43-93.87)], and IL-17E [1.75 (0.66-2.77) vs. 1.19 
      (0.488-2.1615)] were significantly increased in the wheezing group (p<0.05) 
      compared to normal controls, while the level of IFN-gamma/IL-4 had no significant 
      difference between the two groups (1.24 +/- 1.88 vs 0.68 +/- 0.74, p>0.05). There was 
      altered cytokine production in children with wheezing diseases which was quite 
      similar to asthma pathogenesis. Sex, age, pathogen infection, and inflammation in 
      our study were also risk factors for wheezing diseases.
CI  - Copyright (c) 2022 Tang, Yang, He, Huang, Zheng and Liu.
FAU - Tang, Yongjun
AU  - Tang Y
AD  - Department of Pediatrics, Xiangya Hospital, Central South University, Changsha, 
      China.
FAU - Yang, Yaxiong
AU  - Yang Y
AD  - Department of Pediatrics, Xiangya Hospital, Central South University, Changsha, 
      China.
FAU - He, Ruohui
AU  - He R
AD  - Department of Pharmacy, Ningyuan County of People's Hospital, Yongzhou, China.
FAU - Huang, Rong
AU  - Huang R
AD  - Department of Pediatrics, Xiangya Hospital, Central South University, Changsha, 
      China.
FAU - Zheng, Xiangrong
AU  - Zheng X
AD  - Department of Pediatrics, Xiangya Hospital, Central South University, Changsha, 
      China.
FAU - Liu, Chentao
AU  - Liu C
AD  - Department of Pediatrics, Xiangya Hospital, Central South University, Changsha, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20220714
PL  - Switzerland
TA  - Front Oncol
JT  - Frontiers in oncology
JID - 101568867
PMC - PMC9329614
OTO - NOTNLM
OT  - IFN-gamma
OT  - IL-17
OT  - IL-4
OT  - IgE
OT  - MMP
OT  - infant
OT  - wheezing
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/08/02 06:00
MHDA- 2022/08/02 06:01
PMCR- 2022/01/01
CRDT- 2022/08/01 03:58
PHST- 2022/04/17 00:00 [received]
PHST- 2022/06/17 00:00 [accepted]
PHST- 2022/08/01 03:58 [entrez]
PHST- 2022/08/02 06:00 [pubmed]
PHST- 2022/08/02 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fonc.2022.922214 [doi]
PST - epublish
SO  - Front Oncol. 2022 Jul 14;12:922214. doi: 10.3389/fonc.2022.922214. eCollection 
      2022.