PMID- 35914048
OWN - NLM
STAT- MEDLINE
DCOM- 20230406
LR  - 20230428
IS  - 1558-2639 (Electronic)
IS  - 1536-1241 (Linking)
VI  - 22
IP  - 2
DP  - 2023 Apr
TI  - Immunogenic Evaluation of MPEG-PCL & PLGA Nanoparticles Containing Klebsiella 
      pneumoniae K2O1 Capsular Antigen in Pulmonary Infection Model of Mice.
PG  - 393-400
LID - 10.1109/TNB.2022.3195483 [doi]
AB  - Klebsiella pneumoniae can cause destructive changes to human lungs if aspirated. 
      The present study aimed to evaluate the immunogenicity of the carriers of Poly 
      lactic-co-glycolic acid (PLGA) and Methoxypoly(ethylene glycol) 
      Poly(caprolactone) (MPEG-PCL) nanoparticles containing the capsular antigen of 
      Klebsiella pneumoniae K2O1 in a model of pulmonary infection in mice as a vaccine 
      candidate. Capsule antigen was extracted from K.pneumoniae K2O1 strain 1053 ATCC 
      10031 and transported with PLGA or MPEG-PCL nanoparticles as a vaccine in an 
      animal model. The results of FT-IR and AFM confirmed the presence of antigen 
      functional groups in the nanoparticle structure, and semi-spherical shape of the 
      nanoparticles, respectively. The capsular polysaccharide was also used to 
      evaluate the febrileness of the designed vaccine candidates based on the rabbits' 
      pattern, and mortality due to the vaccine candidates in the mice. No fever was 
      observed, and no mortality was observed in the mice. According to the results, 
      the vaccine candidates designed to control the cause of pulmonary infections were 
      effective in the liver, spleen, and lungs of the animals with the ability to 
      enter the first stage of the clinical trial phase.
FAU - Ghaderinia, Parivash
AU  - Ghaderinia P
FAU - Shapouri, Reza
AU  - Shapouri R
FAU - Rostamizadeh, Kobra
AU  - Rostamizadeh K
FAU - Khodavandi, Alireza
AU  - Khodavandi A
FAU - Mahdavi, Mehdi
AU  - Mahdavi M
LA  - eng
PT  - Journal Article
DEP - 20230331
PL  - United States
TA  - IEEE Trans Nanobioscience
JT  - IEEE transactions on nanobioscience
JID - 101152869
RN  - 0 (methoxy poly(ethylene glycol-co-epsilon-caprolactone))
RN  - 0 (Drug Carriers)
RN  - 0 (Polyesters)
RN  - 3WJQ0SDW1A (Polyethylene Glycols)
SB  - IM
MH  - Mice
MH  - Humans
MH  - Animals
MH  - Rabbits
MH  - *Klebsiella pneumoniae
MH  - Spectroscopy, Fourier Transform Infrared
MH  - Drug Carriers/chemistry
MH  - Polyesters/chemistry
MH  - Polyethylene Glycols/chemistry
MH  - *Nanoparticles/chemistry
EDAT- 2022/08/02 06:00
MHDA- 2023/04/06 06:42
CRDT- 2022/08/01 14:13
PHST- 2023/04/06 06:42 [medline]
PHST- 2022/08/02 06:00 [pubmed]
PHST- 2022/08/01 14:13 [entrez]
AID - 10.1109/TNB.2022.3195483 [doi]
PST - ppublish
SO  - IEEE Trans Nanobioscience. 2023 Apr;22(2):393-400. doi: 10.1109/TNB.2022.3195483. 
      Epub 2023 Mar 31.