PMID- 35916162
OWN - NLM
STAT- MEDLINE
DCOM- 20220824
LR  - 20230129
IS  - 1365-2036 (Electronic)
IS  - 0269-2813 (Linking)
VI  - 56
IP  - 6
DP  - 2022 Sep
TI  - Tolerance to sterilised cow's milk in patients with eosinophilic oesophagitis 
      triggered by milk.
PG  - 957-967
LID - 10.1111/apt.17171 [doi]
AB  - BACKGROUND: Cow's milk protein is the main food trigger for eosinophilic 
      oesophagitis (EoE) in children and adults and should be continuously avoided once 
      identified as such. AIMS: To evaluate tolerance of sterilised cow's milk (boiled 
      instead of UHT processing) with regard to maintenance of EoE remission, 
      health-related quality of life (HRQoL), nutritional intake and allergic 
      sensitisation in patients of all ages with milk-triggered EoE METHODS: We 
      prospectively recruited patients in whom cow's milk was demonstrated to trigger 
      EoE after an empirical food elimination diet-based study. They were given 200 ml 
      of sterilised cow's milk twice daily for 8 weeks. Endoscopic assessment, peak 
      eosinophil counts, oesophageal-related symptoms, HRQoL, blood eosinophils, 
      eosinophil cationic protein (ECP), skin prick test and serum total and specific 
      immunoglobulin E (IgE) to major milk proteins were monitored before and after 
      sterilised milk intake. RESULTS: Eighteen patients (13 male) in EoE remission 
      underwent a sterilised milk challenge. Twelve maintained EoE remission (<15 
      eos/hpf) while EoE recurred in the remainder. Endoscopic appearances deteriorated 
      in non-tolerant patients. HRQoL scored well at baseline and was maintained among 
      patients tolerant to sterilised milk, but deteriorated in reactive ones. No 
      significant changes in blood eosinophil count, ECP, tryptase or total and 
      milk-specific IgE serum levels were observed from baseline. However, cow's 
      milk-specific IgE increased slightly in non-tolerant patients. Clinical and 
      histological remission were maintained in patients who regularly consumed 
      sterilised milk for 1 year. CONCLUSION: Sterilised milk did not trigger EoE in 
      two-thirds of patients with documented milk-induced EoE, in either the short or 
      long term.
CI  - (c) 2022 John Wiley & Sons Ltd.
FAU - Gonzalez-Cervera, Jesus
AU  - Gonzalez-Cervera J
AUID- ORCID: 0000-0002-7444-9076
AD  - Department of Allergy, Hospital General de Tomelloso, Tomelloso, Spain.
AD  - Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas 
      (CIBERehd), Madrid, Spain.
AD  - Instituto de Investigacion Sanitaria de Castilla-La Mancha (IDISCAM), Toledo, 
      Spain.
FAU - Arias, Angel
AU  - Arias A
AUID- ORCID: 0000-0003-1006-0958
AD  - Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas 
      (CIBERehd), Madrid, Spain.
AD  - Instituto de Investigacion Sanitaria de Castilla-La Mancha (IDISCAM), Toledo, 
      Spain.
AD  - Research Unit, Hospital General Mancha Centro, Alcazar de San Juan, Spain.
AD  - Instituto de Investigacion Sanitaria Princesa (IIS-IP), Madrid, Spain.
FAU - Navarro, Pilar
AU  - Navarro P
AUID- ORCID: 0000-0002-6293-2570
AD  - Instituto de Investigacion Sanitaria de Castilla-La Mancha (IDISCAM), Toledo, 
      Spain.
AD  - Department of Gastroenterology, Hospital General de Tomelloso, Tomelloso, Spain.
FAU - Juarez-Tosina, Rocio
AU  - Juarez-Tosina R
AD  - Department of Pathology, Hospital General Mancha Centro, Alcazar de San Juan, 
      Spain.
FAU - Cobo-Palacios, Maria
AU  - Cobo-Palacios M
AD  - Nutrition and Dietetics Unit, Hospital General de Tomelloso, Tomelloso, Spain.
FAU - Olalla, Jose M
AU  - Olalla JM
AUID- ORCID: 0000-0003-0388-6241
AD  - Department of Pathology, Hospital General Mancha Centro, Alcazar de San Juan, 
      Spain.
FAU - Angueira-Lapena, Teresa
AU  - Angueira-Lapena T
AD  - Department of Gastroenterology, Hospital General de Tomelloso, Tomelloso, Spain.
FAU - Lucendo, Alfredo J
AU  - Lucendo AJ
AUID- ORCID: 0000-0003-1183-1072
AD  - Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas 
      (CIBERehd), Madrid, Spain.
AD  - Instituto de Investigacion Sanitaria de Castilla-La Mancha (IDISCAM), Toledo, 
      Spain.
AD  - Instituto de Investigacion Sanitaria Princesa (IIS-IP), Madrid, Spain.
AD  - Department of Gastroenterology, Hospital General de Tomelloso, Tomelloso, Spain.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220802
PL  - England
TA  - Aliment Pharmacol Ther
JT  - Alimentary pharmacology & therapeutics
JID - 8707234
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - Eosinophilic enteropathy
SB  - IM
CIN - Aliment Pharmacol Ther. 2022 Oct;56(7):1205-1206. PMID: 36071014
MH  - Allergens
MH  - Animals
MH  - Cattle
MH  - Enteritis
MH  - Eosinophilia
MH  - *Eosinophilic Esophagitis/pathology
MH  - Female
MH  - Gastritis
MH  - Humans
MH  - Immunoglobulin E
MH  - Male
MH  - Milk/adverse effects
MH  - *Milk Hypersensitivity/diagnosis
MH  - Quality of Life
OTO - NOTNLM
OT  - Milk hypersensitivity
OT  - Milk/immunology
OT  - desensitisation
OT  - eosinophilic oesophagitis
OT  - immune tolerance
EDAT- 2022/08/03 06:00
MHDA- 2022/08/25 06:00
CRDT- 2022/08/02 05:23
PHST- 2022/07/09 00:00 [revised]
PHST- 2022/06/15 00:00 [received]
PHST- 2022/07/20 00:00 [accepted]
PHST- 2022/08/03 06:00 [pubmed]
PHST- 2022/08/25 06:00 [medline]
PHST- 2022/08/02 05:23 [entrez]
AID - 10.1111/apt.17171 [doi]
PST - ppublish
SO  - Aliment Pharmacol Ther. 2022 Sep;56(6):957-967. doi: 10.1111/apt.17171. Epub 2022 
      Aug 2.