PMID- 35916370
OWN - NLM
STAT- MEDLINE
DCOM- 20221202
LR  - 20230130
IS  - 1476-6256 (Electronic)
IS  - 0002-9262 (Linking)
VI  - 191
IP  - 12
DP  - 2022 Nov 19
TI  - The Association of Serum High-Sensitivity C-Reactive Protein Level With the Risk 
      of Site-Specific Cancer Mortality: The Health Examinees (HEXA) Study Cohort.
PG  - 2002-2013
LID - 10.1093/aje/kwac141 [doi]
AB  - Few studies have investigated the association between high-sensitivity C-reactive 
      protein (hsCRP) level and site-specific cancer mortality. In this study, we aimed 
      to examine the associations of hsCRP with overall and site-specific cancer 
      mortality among South Koreans using data on the Health Examinees (HEXA) Study 
      cohort (41,070 men and 81,011 women aged >/=40 years). We obtained mortality 
      information from the National Statistical Office of Korea, which provided the 
      dates and causes of all deaths occurring through December 31, 2015, by linking 
      mortality data with each participant's unique national identifier. Cox 
      proportional hazards and restricted cubic spline models were used to assess the 
      association between hsCRP and cancer mortality with adjustment for covariates. An 
      analysis of site-specific cancer mortality was focused on 5 major cancers (lung, 
      liver, gastric, colorectal, and breast/prostate). Median hsCRP levels were 0.77 
      mg/L and 0.59 mg/L for men and women, respectively. A dose-response association 
      between hsCRP and overall cancer mortality was observed in men but disappeared in 
      women after exclusion of deaths occurring in the first 1 or 2 years of follow-up. 
      Elevated hsCRP levels increased the risks of lung, liver, and gastric cancer 
      mortality in men, but the risks of colorectal and breast cancer mortality were 
      not increased. The dose-response association between hsCRP and cancer mortality 
      was observed differently depending on site-specific cancer mortality by sex.
CI  - (c) The Author(s) 2022. Published by Oxford University Press on behalf of the Johns 
      Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, 
      please e-mail: journals.permissions@oup.com.
FAU - Lee, Sang-Ah
AU  - Lee SA
FAU - Kwon, Sung-Ok
AU  - Kwon SO
FAU - Song, Minkyo
AU  - Song M
FAU - Choi, Ji-Yeob
AU  - Choi JY
FAU - Shin, Aesun
AU  - Shin A
FAU - Shu, Xiao-Ou
AU  - Shu XO
FAU - Zheng, Wei
AU  - Zheng W
FAU - Lee, Jong-Koo
AU  - Lee JK
FAU - Kang, Daehee
AU  - Kang D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Epidemiol
JT  - American journal of epidemiology
JID - 7910653
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Male
MH  - Humans
MH  - Female
MH  - C-Reactive Protein/analysis
MH  - Cohort Studies
MH  - *Breast Neoplasms
MH  - *Stomach Neoplasms
MH  - *Colorectal Neoplasms
MH  - Risk Factors
OTO - NOTNLM
OT  - dose-response associations
OT  - high-sensitivity C-reactive protein
OT  - prospective studies
OT  - site-specific cancer mortality
EDAT- 2022/08/03 06:00
MHDA- 2022/12/03 06:00
CRDT- 2022/08/02 07:53
PHST- 2020/09/24 00:00 [received]
PHST- 2021/10/01 00:00 [revised]
PHST- 2022/07/28 00:00 [accepted]
PHST- 2022/08/03 06:00 [pubmed]
PHST- 2022/12/03 06:00 [medline]
PHST- 2022/08/02 07:53 [entrez]
AID - 6653178 [pii]
AID - 10.1093/aje/kwac141 [doi]
PST - ppublish
SO  - Am J Epidemiol. 2022 Nov 19;191(12):2002-2013. doi: 10.1093/aje/kwac141.