PMID- 35916609
OWN - NLM
STAT- MEDLINE
DCOM- 20220804
LR  - 20220804
IS  - 0019-1442 (Print)
IS  - 0019-1442 (Linking)
VI  - 75
IP  - 7-08
DP  - 2022 Jul 30
TI  - Early and late predictors of postoperative neurocognitive dysfunction in cardiac 
      surgery.
PG  - 231-240
LID - 10.18071/isz.75.0231 [doi]
AB  - BACKGROUND AND PURPOSE: Postoperative cognitive dysfunction (POCD) is a 
      multifactorial image characterized by insufficiency in features such as the 
      ability to perform tasks requiring high brain functions. Cognitive dysfunction 
      such as memory loss and decreased concentration, confusion, and delirium are 
      common conditions in some patients in the early period after major surgical 
      interventions such as cardiac surgery. POCD causes delays in postoperative 
      recovery, long return-to-work times, and decreased quality of life. This study 
      aims to demonstrate POCD in early and late stages in patients undergoing cardiac 
      surgery through the Montreal Cognitive Assessment (MoCA) and the Mini Mental Test 
      (MMT). In addition, we aim to determine predictive factors with these 
      neurocognitive tests. METHODS: MMT and MoCA tests were applied to the patients 
      included in the study before cardiac surgery, on the sixth postoperative day and 
      third month. Neuro-cognitive dysfunction detected on the sixth postoperative day 
      was accepted as an early period, its detection in the postoperative third month 
      was accepted as a late period. RESULTS: 127 patients without neurocognitive 
      dysfunction in the preoperative period were included in the study. For early 
      neurocognitive impairment, age, mean platelet volume (MPV), New York Heart 
      Association (NYHA) classification, x-clamp time, cardio-pulmonary bypass (CPB) 
      time, postoperative intensive care and hospital stay duration, and an event of 
      acute myocardial infarction (AMI) in the preoperative period were determined as 
      predictive factors. In addition, in late-period of neurocognitive dysfunction 
      age, MPV, NYHA classification, x-clamp duration, CPB time, postoperative 
      intensive care and hospital stay duration were shown as predictors of 
      neurocognitive dysfunction. CONCLUSION: The results of our study support the 
      literature findings showing that delirium is associated with a decline in 
      cognitive functions three months after cardiac surgery. As a result, the lack of 
      agreed diagnostic tests in the definition of POCD makes it difficult to 
      standardize and interpret the research in this area. Therefore, a consensus to be 
      reached in the diagnosis of POCD will ensure the use and correct interpretation 
      of neurophysiological tests. In our study, advanced age and long hospital and 
      intensive care stays were shown as predictive factors for both early and late 
      neurocognitive dysfunctions. Furthermore, smoking was shown as a predictive 
      factor only for late neurocognitive dysfunction.
FAU - Urcun, Yusuf Salim
AU  - Urcun YS
AUID- ORCID: 0000000210611900
AD  - Department of Cardiovascular Surgery, Adiyaman Training and Research Hospital, 
      Adiyaman, Turkey.
FAU - Altun, Yasar
AU  - Altun Y
AD  - Department of Neurology, Adiyaman Training and Research Hospital, Adiyaman, 
      Turkey.
FAU - Pala, Arda Aybars
AU  - Pala AA
AD  - Department of Cardiovascular Surgery, Adiyaman Training and Research Hospital, 
      Adiyaman, Turkey.
LA  - eng
PT  - Journal Article
TT  - A posztoperativ neurokognitiv diszfunkcio korai es kesoi prediktorai 
      szivsebeszeti beavatkozas utan.
PL  - Hungary
TA  - Ideggyogy Sz
JT  - Ideggyogyaszati szemle
JID - 17510500R
SB  - IM
MH  - *Cardiac Surgical Procedures/adverse effects
MH  - Cognition
MH  - *Cognitive Dysfunction/diagnosis/etiology
MH  - *Delirium/diagnosis/etiology
MH  - Humans
MH  - *Postoperative Cognitive Complications
MH  - Quality of Life
OTO - NOTNLM
OT  - Mini Mental test
OT  - Montreal cognitive assesment
OT  - cardiac surgery
OT  - neurocognitive disfunction
EDAT- 2022/08/03 06:00
MHDA- 2022/08/05 06:00
CRDT- 2022/08/02 09:33
PHST- 2022/08/02 09:33 [entrez]
PHST- 2022/08/03 06:00 [pubmed]
PHST- 2022/08/05 06:00 [medline]
AID - 10.18071/isz.75.0231 [doi]
PST - ppublish
SO  - Ideggyogy Sz. 2022 Jul 30;75(7-08):231-240. doi: 10.18071/isz.75.0231.