PMID- 35917518
OWN - NLM
STAT- MEDLINE
DCOM- 20220815
LR  - 20220816
IS  - 1557-8100 (Electronic)
IS  - 1536-2310 (Linking)
VI  - 26
IP  - 8
DP  - 2022 Aug
TI  - Acute Ischemic Stroke Comorbid with Type 2 Diabetes: Long-Term Prognosis 
      Determinants in a 36-Month Prospective Study for Personalized Medicine.
PG  - 451-460
LID - 10.1089/omi.2022.0071 [doi]
AB  - Ischemic stroke (IS) is often comorbid with type 2 diabetes mellitus (T2DM) 
      wherein the determinants of long-term outcomes, beyond the acute stroke phase, 
      are not adequately known. This study identified the determinants of long-term 
      outcomes for diabetic IS patients through a prospective nested case-control study 
      in 624 patients treated with conservative measures (38.60% females, mean age: 
      63.85 years). After 36-month follow-up, 117 (18.8%) patients with poor outcome 
      were enrolled in the case group. The poor outcome was defined with a modified 
      Rankin Scale (mRS) score >/=3. Meanwhile, 374 (59.9%) patients with good outcome, 
      defined as (mRS score <3), were included in the control group. Patients who died 
      (n = 32) or lost to follow-up (n = 101) were excluded in analysis. Poor 
      prognostic outcome was positively associated with (1) the pulse rate at 
      admission, (2) diastolic blood pressure (DBP), and (3) fasting blood glucose 
      (FBG) during follow-up, whereas physical activity and lipid-lowering treatment 
      during follow-up were negatively associated. Importantly, a forecasting model 
      with these indicators distinguished the patients with good versus poor outcomes 
      with 70.1% sensitivity and 73.5% specificity. Health care professionals and 
      laboratory medicine scholars may want to monitor an increase in DBP and FBG 
      during follow-up, as well as physical activity and lipid-lowering treatment, in 
      relationship to the prognosis of IS with comorbid T2DM after conservative 
      therapies. The proposed predictive model for personalized/precision medicine 
      requires field testing in independent studies, and might help risk stratification 
      with theranostic tests for patients with acute IS who also have a diagnosis of 
      T2DM.
FAU - Liu, Pengcheng
AU  - Liu P
AD  - Department of Epidemiology, School of Public Health, Shandong First Medical 
      University & Shandong Academy of Medical Sciences, Taian, China.
FAU - Hao, Jiheng
AU  - Hao J
AD  - Department of Neurosurgery, Liaocheng People's Hospital, Liaocheng, China.
FAU - Zhang, Yichun
AU  - Zhang Y
AD  - Department of Epidemiology, School of Public Health, Shandong First Medical 
      University & Shandong Academy of Medical Sciences, Taian, China.
FAU - Wang, Lu
AU  - Wang L
AD  - Department of Epidemiology, School of Public Health, Shandong First Medical 
      University & Shandong Academy of Medical Sciences, Taian, China.
FAU - Liu, Chao
AU  - Liu C
AD  - Department of Neurosurgery, Liaocheng People's Hospital, Liaocheng, China.
FAU - Wang, Jiyue
AU  - Wang J
AD  - Department of Neurosurgery, Liaocheng People's Hospital, Liaocheng, China.
FAU - Feng, Jingjun
AU  - Feng J
AD  - Department of Neurosurgery, Liaocheng People's Hospital, Liaocheng, China.
FAU - Zhang, Yanbo
AU  - Zhang Y
AUID- ORCID: 0000-0002-0829-9815
AD  - Department of Neurology, The Second Affiliated Hospital of Shandong First Medical 
      University, Taian, China.
FAU - Hou, Haifeng
AU  - Hou H
AUID- ORCID: 0000-0002-1131-1619
AD  - Department of Epidemiology, School of Public Health, Shandong First Medical 
      University & Shandong Academy of Medical Sciences, Taian, China.
FAU - Zhang, Liyong
AU  - Zhang L
AD  - Department of Neurosurgery, Liaocheng People's Hospital, Liaocheng, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220802
PL  - United States
TA  - OMICS
JT  - Omics : a journal of integrative biology
JID - 101131135
RN  - 0 (Lipids)
SB  - IM
MH  - *Brain Ischemia/complications
MH  - Case-Control Studies
MH  - *Diabetes Mellitus, Type 2/complications/epidemiology
MH  - Female
MH  - Humans
MH  - *Ischemic Stroke
MH  - Lipids
MH  - Male
MH  - Middle Aged
MH  - Precision Medicine
MH  - Prospective Studies
MH  - Risk Factors
MH  - *Stroke/epidemiology
OTO - NOTNLM
OT  - diagnostic medicine
OT  - ischemic stroke
OT  - personalized medicine
OT  - public health
OT  - theranostics
OT  - type 2 diabetes mellitus
EDAT- 2022/08/03 06:00
MHDA- 2022/08/16 06:00
CRDT- 2022/08/02 16:53
PHST- 2022/08/03 06:00 [pubmed]
PHST- 2022/08/16 06:00 [medline]
PHST- 2022/08/02 16:53 [entrez]
AID - 10.1089/omi.2022.0071 [doi]
PST - ppublish
SO  - OMICS. 2022 Aug;26(8):451-460. doi: 10.1089/omi.2022.0071. Epub 2022 Aug 2.