PMID- 35917689
OWN - NLM
STAT- MEDLINE
DCOM- 20220919
LR  - 20220919
IS  - 1873-4367 (Electronic)
IS  - 0927-7765 (Linking)
VI  - 218
DP  - 2022 Oct
TI  - Nerve implants with bioactive interfaces enhance neurite outgrowth and nerve 
      regeneration in vivo.
PG  - 112731
LID - S0927-7765(22)00414-3 [pii]
LID - 10.1016/j.colsurfb.2022.112731 [doi]
AB  - Nerve implants functionalized with growth factors and stem cells are critical to 
      promote neurite outgrowth, regulate neurodifferentiation, and facilitate nerve 
      regeneration. In this study, human umbilical cord mesenchymal stem cells 
      (hUCMSCs) and 3,4-hydroxyphenalyalanine (DOPA)-containing insulin-like growth 
      factor 1 (DOPA-IGF-1) were simultaneously applied to enhance the bioactivity of 
      poly(lactide-co-glycolide) (PLGA) substrates which will be potentially utilized 
      as nerve implants. In vitro and in vivo evaluations indicated that hUCMSCs and 
      DOPA-IGF-1 could synergistically regulate neurite outgrowth of PC12 cells, 
      improve intravital recovery of motor functions, and promote conduction of nerve 
      electrical signals in vivo. The enhanced functional and structural nerve 
      regeneration of injured spinal cord might be mainly attributable to the 
      synergistically enhanced biofunctionality of hUCMSCs and DOPA-IGF-1/PLGA on the 
      bioactive interfaces. Findings from this study demonstrate the potential of 
      hUCMSC-seeded, DOPA-IGF-1-modified PLGA implants as promising candidates for 
      promoting axonal regeneration and motor functional recovery in spinal cord injury 
      treatment.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Wang, Zongliang
AU  - Wang Z
AD  - Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, 
      Chinese Academy of Sciences, Changchun 130022, PR China.
FAU - Zhang, Yi
AU  - Zhang Y
AD  - Department of Urology, The Second Hospital, Jilin University, Changchun 130041, 
      PR China.
FAU - Wang, Liqiang
AU  - Wang L
AD  - Department of Ophthalmology, Third Medical Center, Chinese PLA General Hospital, 
      Beijing 100853, PR China.
FAU - Ito, Yoshihiro
AU  - Ito Y
AD  - Nano Medical Engineering Laboratory, RIKEN Cluster for Pioneering Research, 
      Saitama 351-0198, Japan.
FAU - Li, Gang
AU  - Li G
AD  - Department of Orthopaedics and Traumatology and Li Ka Shing Institute of Health 
      Sciences, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, 
      Hong Kong Special Administrative Region of China.
FAU - Zhang, Peibiao
AU  - Zhang P
AD  - Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, 
      Chinese Academy of Sciences, Changchun 130022, PR China. Electronic address: 
      zhangpb@ciac.ac.cn.
LA  - eng
PT  - Journal Article
DEP - 20220727
PL  - Netherlands
TA  - Colloids Surf B Biointerfaces
JT  - Colloids and surfaces. B, Biointerfaces
JID - 9315133
RN  - 34346-01-5 (Polyglactin 910)
RN  - 63-84-3 (Dihydroxyphenylalanine)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Animals
MH  - Dihydroxyphenylalanine
MH  - Humans
MH  - *Insulin-Like Growth Factor I/pharmacology
MH  - Nerve Regeneration/physiology
MH  - Neuronal Outgrowth
MH  - Polyglactin 910
MH  - Rats
MH  - *Spinal Cord Injuries/metabolism/therapy
OTO - NOTNLM
OT  - Bioactive interfaces
OT  - DOPA-IGF-1
OT  - HUCMSCs
OT  - Implants
OT  - Neural regeneration
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2022/08/03 06:00
MHDA- 2022/09/20 06:00
CRDT- 2022/08/02 18:21
PHST- 2022/04/19 00:00 [received]
PHST- 2022/07/08 00:00 [revised]
PHST- 2022/07/25 00:00 [accepted]
PHST- 2022/08/03 06:00 [pubmed]
PHST- 2022/09/20 06:00 [medline]
PHST- 2022/08/02 18:21 [entrez]
AID - S0927-7765(22)00414-3 [pii]
AID - 10.1016/j.colsurfb.2022.112731 [doi]
PST - ppublish
SO  - Colloids Surf B Biointerfaces. 2022 Oct;218:112731. doi: 
      10.1016/j.colsurfb.2022.112731. Epub 2022 Jul 27.