PMID- 35918031
OWN - NLM
STAT- MEDLINE
DCOM- 20220908
LR  - 20220908
IS  - 1878-3511 (Electronic)
IS  - 1201-9712 (Linking)
VI  - 122
DP  - 2022 Sep
TI  - Clinical features and prognostic predictors in patients with rheumatic diseases 
      complicated by Pneumocystis pneumonia.
PG  - 1018-1025
LID - S1201-9712(22)00465-9 [pii]
LID - 10.1016/j.ijid.2022.07.070 [doi]
AB  - OBJECTIVES: To investigate the clinical outcomes and risk factors of mortality in 
      patients with rheumatic diseases complicated by Pneumocystis pneumonia (PCP). 
      METHODS: Between November 2015 and April 2021, patients with rheumatic diseases 
      with PCP in a tertiary referral hospital were retrospectively enrolled. The 
      diagnosis of PCP requires the fulfillment of clinical, radiographic, and 
      microbiological criteria. Factors associated with in-hospital, 30-day, and 90-day 
      mortality were evaluated. RESULTS: A total of 128 patients with rheumatic 
      diseases who had a positive quantitative polymerase chain reaction assay for 
      Pneumocystis jirovecii were screened, and 72 patients were included in the final 
      analysis. The median (interquartile range [IQR]) pneumonia severity index (PSI) 
      was 101.5 (77.0-132.0). The median (IQR) adjunctive corticosteroid dosage was 0.6 
      (0.4-0.9) mg/kg/day prednisolone equivalent. The receiver operating 
      characteristic curve analysis showed that the optimal cutoff point of median 
      adjunctive corticosteroid dosage was 0.6 mg/kg/day to predict in-hospital, 
      30-day, and 90-day mortality. In the multivariable logistic regression analysis, 
      median adjunctive corticosteroid dosage >/=0.6 mg/kg/day and PSI >90 were 
      independent factors of in-hospital, 30-day, and 90-day mortality. CONCLUSION: A 
      median adjunctive corticosteroid dosage of >/=0.6 mg/kg/day might be associated 
      with mortality in patients with rheumatic diseases complicated by PCP.
CI  - Copyright (c) 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Huang, Yi-Min
AU  - Huang YM
AD  - Department of Internal Medicine, National Taiwan University Hospital Yunlin 
      Branch, Yunlin County, Taiwan; Department of Medicine, National Taiwan University 
      Cancer Center, Taipei City, Taiwan.
FAU - Lu, Cheng-Hsun
AU  - Lu CH
AD  - Department of Internal Medicine, National Taiwan University Hospital, Taipei 
      City, Taiwan; Graduate Institute of Clinical Medicine, College of Medicine, 
      National Taiwan University, Taipei City, Taiwan.
FAU - Cheng, Chiao-Feng
AU  - Cheng CF
AD  - Department of Internal Medicine, National Taiwan University Hospital Yunlin 
      Branch, Yunlin County, Taiwan; Department of Internal Medicine, National Taiwan 
      University Hospital, Taipei City, Taiwan.
FAU - Shen, Chieh-Yu
AU  - Shen CY
AD  - Department of Internal Medicine, National Taiwan University Hospital, Taipei 
      City, Taiwan; Graduate Institute of Clinical Medicine, College of Medicine, 
      National Taiwan University, Taipei City, Taiwan.
FAU - Hsieh, Song-Chou
AU  - Hsieh SC
AD  - Department of Internal Medicine, National Taiwan University Hospital, Taipei 
      City, Taiwan.
FAU - Li, Ko-Jen
AU  - Li KJ
AD  - Department of Internal Medicine, National Taiwan University Hospital, Taipei 
      City, Taiwan. Electronic address: dtmed170@gmail.com.
FAU - Chien, Jung-Yien
AU  - Chien JY
AD  - Department of Internal Medicine, National Taiwan University Hospital, Taipei 
      City, Taiwan. Electronic address: jychien@ntu.edu.tw.
FAU - Hsueh, Po-Ren
AU  - Hsueh PR
AD  - Department of Internal Medicine, National Taiwan University Hospital, Taipei 
      City, Taiwan; Department of Laboratory Medicine, National Taiwan University 
      Hospital, Taipei City, Taiwan; Departments of Laboratory Medicine and Internal 
      Medicine, China Medical University Hospital, Taichung City, Taiwan; School of 
      Medicine, China Medical University, Taichung City, Taiwan; Ph.D. Program for 
      Aging, College of Medicine, China Medical University, Taichung City, Taiwan.
CN  - TACTICS Study Group
LA  - eng
PT  - Journal Article
DEP - 20220730
PL  - Canada
TA  - Int J Infect Dis
JT  - International journal of infectious diseases : IJID : official publication of the 
      International Society for Infectious Diseases
JID - 9610933
RN  - 0 (Adrenal Cortex Hormones)
SB  - IM
MH  - Adrenal Cortex Hormones/therapeutic use
MH  - Humans
MH  - *Pneumocystis carinii
MH  - *Pneumonia, Pneumocystis/complications/diagnosis/drug therapy
MH  - Prognosis
MH  - Retrospective Studies
MH  - *Rheumatic Diseases/complications/drug therapy
OTO - NOTNLM
OT  - Adjunctive corticosteroid dosage
OT  - Mortality
OT  - Pneumocystis pneumonia
OT  - Pneumonia severity index
OT  - Rheumatic diseases
EDAT- 2022/08/03 06:00
MHDA- 2022/09/09 06:00
CRDT- 2022/08/02 19:24
PHST- 2022/06/06 00:00 [received]
PHST- 2022/07/19 00:00 [revised]
PHST- 2022/07/27 00:00 [accepted]
PHST- 2022/08/03 06:00 [pubmed]
PHST- 2022/09/09 06:00 [medline]
PHST- 2022/08/02 19:24 [entrez]
AID - S1201-9712(22)00465-9 [pii]
AID - 10.1016/j.ijid.2022.07.070 [doi]
PST - ppublish
SO  - Int J Infect Dis. 2022 Sep;122:1018-1025. doi: 10.1016/j.ijid.2022.07.070. Epub 
      2022 Jul 30.