PMID- 35918449
OWN - NLM
STAT- MEDLINE
DCOM- 20220804
LR  - 20221014
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 12
IP  - 1
DP  - 2022 Aug 2
TI  - Mindfulness meditation increases default mode, salience, and central executive 
      network connectivity.
PG  - 13219
LID - 10.1038/s41598-022-17325-6 [doi]
LID - 13219
AB  - Recent research has begun to identify the neural mechanisms underlying the 
      beneficial impact of mindfulness meditation training (MMT) on health and 
      cognition. However, little is known about the effects of MMT on the global 
      interplay of large-scale networks (LSNs) in the brain. In the present study, 
      healthy, meditation-naive adults (N = 46) underwent resting state fMRI prior to 
      and upon completing 31 days of MMT or an active control intervention. Independent 
      component analysis, sliding time window, and seed-based correlation analyses were 
      performed to assess training-related changes in functional connectivity (FC) 
      within and between networks with relevance to mindfulness meditation. Across 
      sliding time window analyses and seed-based correlation analyses, we found 
      increased FC between nodes of the default mode network (DMN) and nodes of the 
      salience network (SN) in participants of the MMT. Seed-based correlation analyses 
      revealed further connectivity increases between the SN and key regions of the 
      central executive network (CEN). These results indicate, that, among multiple 
      LSNs, one month of mindfulness meditation effectively increases interconnectivity 
      between networks of the triple network model (DMN, SN, CEN), hereby introducing a 
      potential mechanistic concept underlying the beneficial impact of MMT.Clinical 
      trial registration: This study is listed as a clinical trial on the ISRCTN 
      registry with trial ID ISRCTN95197731 (date of first registration: 15/02/2022).
CI  - (c) 2022. The Author(s).
FAU - Bremer, Benno
AU  - Bremer B
AD  - Department of Neuroradiology, School of Medicine, Klinikum Rechts Der Isar, 
      Technical University of Munich, Ismaninger Str. 22, 81675, Munich, Germany. 
      benno.bremer@tum.de.
AD  - TUM-Neuroimaging Center (TUM-NIC), Technical University of Munich, Munich, 
      Germany. benno.bremer@tum.de.
FAU - Wu, Qiong
AU  - Wu Q
AD  - Department of Neuroradiology, School of Medicine, Klinikum Rechts Der Isar, 
      Technical University of Munich, Ismaninger Str. 22, 81675, Munich, Germany.
AD  - TUM-Neuroimaging Center (TUM-NIC), Technical University of Munich, Munich, 
      Germany.
AD  - Institute of Medical Psychology, Ludwig-Maximilians-Universitat Munchen, Munich, 
      Germany.
FAU - Mora Alvarez, Maria Guadalupe
AU  - Mora Alvarez MG
AD  - Department of Neuroradiology, School of Medicine, Klinikum Rechts Der Isar, 
      Technical University of Munich, Ismaninger Str. 22, 81675, Munich, Germany.
AD  - TUM-Neuroimaging Center (TUM-NIC), Technical University of Munich, Munich, 
      Germany.
FAU - Holzel, Britta Karen
AU  - Holzel BK
AD  - Department of Neuroradiology, School of Medicine, Klinikum Rechts Der Isar, 
      Technical University of Munich, Ismaninger Str. 22, 81675, Munich, Germany.
AD  - TUM-Neuroimaging Center (TUM-NIC), Technical University of Munich, Munich, 
      Germany.
FAU - Wilhelm, Maximilian
AU  - Wilhelm M
AD  - TUM-Neuroimaging Center (TUM-NIC), Technical University of Munich, Munich, 
      Germany.
AD  - Heidelberg University Hospital, Heidelberg, Germany.
FAU - Hell, Elena
AU  - Hell E
AD  - Department of Psychology, Ludwig-Maximilians-Universitat Munchen, Munich, 
      Germany.
FAU - Tavacioglu, Ebru Ecem
AU  - Tavacioglu EE
AD  - TUM-Neuroimaging Center (TUM-NIC), Technical University of Munich, Munich, 
      Germany.
AD  - Department of Psychology, Ludwig-Maximilians-Universitat Munchen, Munich, 
      Germany.
FAU - Torske, Alyssa
AU  - Torske A
AD  - Department of Neuroradiology, School of Medicine, Klinikum Rechts Der Isar, 
      Technical University of Munich, Ismaninger Str. 22, 81675, Munich, Germany.
AD  - TUM-Neuroimaging Center (TUM-NIC), Technical University of Munich, Munich, 
      Germany.
AD  - Graduate School of Systemic Neurosciences, Ludwig-Maximilians-Universitat 
      Munchen, Martinsried, Germany.
FAU - Koch, Kathrin
AU  - Koch K
AD  - Department of Neuroradiology, School of Medicine, Klinikum Rechts Der Isar, 
      Technical University of Munich, Ismaninger Str. 22, 81675, Munich, Germany.
AD  - TUM-Neuroimaging Center (TUM-NIC), Technical University of Munich, Munich, 
      Germany.
AD  - Graduate School of Systemic Neurosciences, Ludwig-Maximilians-Universitat 
      Munchen, Martinsried, Germany.
LA  - eng
SI  - ISRCTN/ISRCTN95197731
PT  - Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220802
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Adult
MH  - Brain/diagnostic imaging
MH  - Brain Mapping/methods
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - *Meditation/methods
MH  - *Mindfulness/methods
MH  - Nerve Net/diagnostic imaging
PMC - PMC9346127
COIS- Britta Karen Holzel commercially provides access to the online mindfulness 
      training that was used as the experimental treatment in this study. The other 
      authors do not have competing interests.
EDAT- 2022/08/03 06:00
MHDA- 2022/08/05 06:00
PMCR- 2022/08/02
CRDT- 2022/08/02 23:27
PHST- 2022/01/27 00:00 [received]
PHST- 2022/07/25 00:00 [accepted]
PHST- 2022/08/02 23:27 [entrez]
PHST- 2022/08/03 06:00 [pubmed]
PHST- 2022/08/05 06:00 [medline]
PHST- 2022/08/02 00:00 [pmc-release]
AID - 10.1038/s41598-022-17325-6 [pii]
AID - 17325 [pii]
AID - 10.1038/s41598-022-17325-6 [doi]
PST - epublish
SO  - Sci Rep. 2022 Aug 2;12(1):13219. doi: 10.1038/s41598-022-17325-6.