PMID- 35921704
OWN - NLM
STAT- MEDLINE
DCOM- 20220823
LR  - 20220823
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Linking)
VI  - 623
DP  - 2022 Oct 1
TI  - HS1BP3, transcriptionally regulated by ESR1, promotes hepatocellular carcinoma 
      progression.
PG  - 111-119
LID - S0006-291X(22)01016-6 [pii]
LID - 10.1016/j.bbrc.2022.07.047 [doi]
AB  - PURPOSE: To explore the role of HS1-binding protein 3 (HS1BP3) in hepatocellular 
      carcinoma (HCC) and the potential mechanism. METHODS: The effect of HS1BP3 in the 
      prognosis of HCC was analyzed. The influence of HS1BP3 silence on proliferation, 
      migration, cell cycle, and apoptosis of HCC cells (Huh-7 and Sun-449) were 
      evaluated. The upstream transcription factors of HS1BP3 were further explored. 
      RESULTS: The high expression of HS1BP3 in HCC was significantly associated with 
      poor prognosis. The silencing of HS1BP3 inhibited proliferation, invasion, 
      migration, and promoted G1 phase cell cycle arrest and apoptosis of HCC cells. 
      Estrogen receptors 1 (ESR1) inhibited proliferation and improved the prognosis of 
      HCC via fusion with HS1BP3 promoter. CONCLUSION: HS1BP3 may serve as a novel 
      tumor-promoting factor transcriptionally regulated by ESR1.
CI  - Copyright (c) 2022 Elsevier Inc. All rights reserved.
FAU - Hu, Xiaosi
AU  - Hu X
AD  - Department of General Surgery, The First Affiliated Hospital of Anhui Medical 
      University, Hefei, 230001, People's Republic of China.
FAU - Pan, Hongtao
AU  - Pan H
AD  - Department of General Surgery, Anhui No.2 Provincial People's Hospital, No. 1868 
      Dangshan Road, North Second Ring, Hefei, 230041, Anhui, China.
FAU - Zhou, Shuai
AU  - Zhou S
AD  - Department of General Surgery, Anhui No.2 Provincial People's Hospital, No. 1868 
      Dangshan Road, North Second Ring, Hefei, 230041, Anhui, China.
FAU - Pang, Qing
AU  - Pang Q
AD  - Department of General Surgery, Anhui No.2 Provincial People's Hospital, No. 1868 
      Dangshan Road, North Second Ring, Hefei, 230041, Anhui, China.
FAU - Wang, Yong
AU  - Wang Y
AD  - Department of General Surgery, Anhui No.2 Provincial People's Hospital, No. 1868 
      Dangshan Road, North Second Ring, Hefei, 230041, Anhui, China.
FAU - Zhu, Chao
AU  - Zhu C
AD  - Department of General Surgery, Anhui No.2 Provincial People's Hospital, No. 1868 
      Dangshan Road, North Second Ring, Hefei, 230041, Anhui, China.
FAU - Liu, Huichun
AU  - Liu H
AD  - Department of General Surgery, Anhui No.2 Provincial People's Hospital, No. 1868 
      Dangshan Road, North Second Ring, Hefei, 230041, Anhui, China.
FAU - Jin, Hao
AU  - Jin H
AD  - Department of General Surgery, Anhui No.2 Provincial People's Hospital, No. 1868 
      Dangshan Road, North Second Ring, Hefei, 230041, Anhui, China. Electronic 
      address: jinhaogandan@163.com.
FAU - Xu, Aman
AU  - Xu A
AD  - Department of General Surgery, The First Affiliated Hospital of Anhui Medical 
      University, Hefei, 230001, People's Republic of China. Electronic address: 
      xuaman@ahmu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220719
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
SB  - IM
MH  - Apoptosis/genetics
MH  - *Carcinoma, Hepatocellular/pathology
MH  - Cell Line, Tumor
MH  - Cell Movement/genetics
MH  - Cell Proliferation/genetics
MH  - G1 Phase Cell Cycle Checkpoints
MH  - Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - *Liver Neoplasms/pathology
OTO - NOTNLM
OT  - ESR1
OT  - HS1BP3
OT  - Hepatocellular carcinoma
OT  - Prognosis
COIS- Declaration of competing interest The authors declare no conflict of interest.
EDAT- 2022/08/04 06:00
MHDA- 2022/08/24 06:00
CRDT- 2022/08/03 18:14
PHST- 2022/06/21 00:00 [received]
PHST- 2022/07/08 00:00 [revised]
PHST- 2022/07/13 00:00 [accepted]
PHST- 2022/08/04 06:00 [pubmed]
PHST- 2022/08/24 06:00 [medline]
PHST- 2022/08/03 18:14 [entrez]
AID - S0006-291X(22)01016-6 [pii]
AID - 10.1016/j.bbrc.2022.07.047 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2022 Oct 1;623:111-119. doi: 
      10.1016/j.bbrc.2022.07.047. Epub 2022 Jul 19.