PMID- 35922164
OWN - NLM
STAT- MEDLINE
DCOM- 20220805
LR  - 20220805
IS  - 0529-5807 (Print)
IS  - 0529-5807 (Linking)
VI  - 51
IP  - 8
DP  - 2022 Aug 8
TI  - [Myxiod pleomorphic liposarcoma: a clinicopathological and molecular genetic 
      analysis of six cases].
PG  - 738-742
LID - 10.3760/cma.j.cn112151-20220524-00441 [doi]
AB  - Objective: To investigate the clinicopathologic and molecular genetic 
      characteristics of myxoid pleomorphic liposarcoma (MPLPS). Methods: Six cases of 
      MPLPS diagnosed and consulted in Fujian Provincial Hospital from 2015 to 2021 
      were collected for histomorphological observation, immunohistochemistry, and 
      fluorescence in situ hybridization (FISH) detection of DDIT3 (CHOP) gene 
      translocation and MDM2/CDK4 gene amplification. Results: There were four males 
      and two females, aged 26-74 years (mean 53.8 years). The tumor size was 3.8-16.0 
      cm (mean 11.8 cm). All six cases had similar histopathologic features, showing 
      overlapping histologic morphology of myxoid liposarcoma and pleomorphic 
      liposarcoma. Four cases (4/6) were positive for S-100 protein, and the Ki-67 
      index was 50%-95%. All cases (6/6) were negative for DDIT3 (CHOP) translocation 
      and MDM2/CDK4 amplification by FISH. TP53 (p.R248w) germline mutation was found 
      in one case. Conclusions: MPLPS is a rare subtype of liposarcoma, characterized 
      by overlapping morphology of myxoid liposarcoma and pleomorphic liposarcoma. 
      Genetically, a few of them have TP53 gene germline mutations, but they lack of 
      DDIT3 (CHOP) translocation or MDM2/CDK4 amplification.
FAU - Zheng, X C
AU  - Zheng XC
AD  - Department of Pathology, Xiamen Third Hospital Affiliated to Fujian University of 
      Traditional Chinese Medicine, Xiamen 361100, China Department of Pathology, 
      Fujian Provincial Hospital, Fujian Provincial Clinical Medical College, Fujian 
      Medical University, Fuzhou 350001, China.
FAU - Huang, H J
AU  - Huang HJ
AD  - Department of Pathology, Fujian Provincial Hospital, Fujian Provincial Clinical 
      Medical College, Fujian Medical University, Fuzhou 350001, China.
FAU - You, J
AU  - You J
AD  - Department of Pathology, Fujian Provincial Hospital South Branch, Fuzhou 350028, 
      China.
FAU - Lin, X Y
AU  - Lin XY
AD  - Department of Pathology, Fujian Provincial Hospital, Fujian Provincial Clinical 
      Medical College, Fujian Medical University, Fuzhou 350001, China.
FAU - Chen, D R
AU  - Chen DR
AD  - Department of Pathology, Fujian Provincial Hospital, Fujian Provincial Clinical 
      Medical College, Fujian Medical University, Fuzhou 350001, China.
FAU - Zhong, Dingrong
AU  - Zhong D
AD  - Department of Pathology, China-Japan Friendship Hospital, Beijing 100029, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Bing Li Xue Za Zhi
JT  - Zhonghua bing li xue za zhi = Chinese journal of pathology
JID - 0005331
RN  - EC 2.3.2.27 (Proto-Oncogene Proteins c-mdm2)
SB  - IM
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Hybridization, Fluorescence
MH  - *Liposarcoma/genetics/pathology
MH  - *Liposarcoma, Myxoid/diagnosis
MH  - Male
MH  - Molecular Biology
MH  - Proto-Oncogene Proteins c-mdm2/genetics
MH  - Translocation, Genetic
EDAT- 2022/08/04 06:00
MHDA- 2022/08/06 06:00
CRDT- 2022/08/03 21:44
PHST- 2022/08/03 21:44 [entrez]
PHST- 2022/08/04 06:00 [pubmed]
PHST- 2022/08/06 06:00 [medline]
AID - 10.3760/cma.j.cn112151-20220524-00441 [doi]
PST - ppublish
SO  - Zhonghua Bing Li Xue Za Zhi. 2022 Aug 8;51(8):738-742. doi: 
      10.3760/cma.j.cn112151-20220524-00441.