PMID- 35922190
OWN - NLM
STAT- MEDLINE
DCOM- 20220805
LR  - 20220805
IS  - 0578-1310 (Print)
IS  - 0578-1310 (Linking)
VI  - 60
IP  - 8
DP  - 2022 Aug 2
TI  - [Predictive value of blood cell parameters in the diagnosis of vasovagal syncope 
      in children].
PG  - 792-797
LID - 10.3760/cma.j.cn112140-20220129-00098 [doi]
AB  - Objective: To investigate the predictive value of blood cell parameters in 
      children with vasovagal syncope (VVS). Methods: In this case-control study, the 
      VVS group included 111 patients with unexplained syncope or prodromata who were 
      diagnosed with VVS by head-up tilt test in the Second Xiangya Hospital, Central 
      South University from January 2018 to October 2020, and 111 healthy children were 
      enrolled as control. The differences in blood cell parameters between the 2 
      groups were compared by t test and Mann-Whitney U test. Multivariate binary 
      Logistic regression was used to analyze the independent correlation factors of 
      VVS, and receiver operating characteristic (ROC) curve to explore the predictive 
      value of blood cell parameters for diagnosing VVS. Results: Sex composition 
      ratios were consistent in the 2 groups (51 males vs. 60 females), while the age 
      of the VVS group was higher than that of the control group (11.0 (8.0, 12.5) vs. 
      8.0 (7.0, 11.0) years, Z=4.39, P<0.001). Compared with the control group, VVS 
      group had lower level of white blood cell (WBC) (6.0 (5.3, 7.1)x10(9) vs. 8.6 
      (6.7, 10.1)x10(9)/L, Z=-7.96, P<0.001), lymphocyte (LY) (2.3 (1.9, 2.7)x10(9) vs. 
      4.0 (2.8, 6.3)x10(9)/L, Z=-8.49, P<0.001), lymphocyte ratio (0.39 (0.33, 0.44) 
      vs. 0.52 (0.37, 0.69), Z=-5.59, P<0.001), monocyte (0.3 (0.3, 0.4)x10(9) vs. 0.4 
      (0.3, 0.6)x10(9)/L, Z=-6.19, P<0.001), eosinophil (0.1 (0.1, 0.2)x10(9) vs. 0.2 
      (0.2, 0.4)x10(9)/L, Z=-5.75, P<0.001), mean corpuscular-hemoglobin concentration 
      (MCHC) ((328+/-12) vs. (333+/-11) g/L, t=-3.27, P<0.001) and blood platelet (263 
      (235, 313)x10(9) vs. 341 (295, 409)x10(9)/L, Z=-2.69, P<0.001), but higher 
      neutrophil ratio (0.53 (0.48, 0.58) vs. 0.37 (0.22, 0.54), Z=5.86, P<0.001), 
      hematocrit (0.39+/-0.04 vs. 0.37+/-0.04, t=2.75, P=0.006), mean corpuscular volume 
      (MCV) (85 (82, 88) vs. 81 (78, 84) fl, Z=5.56, P<0.001), mean corpuscular 
      hemoglobin (28 (27, 29) vs. 27 (26, 28) pg, Z=3.39, P=0.001), red cell 
      distribution width (39 (37, 41) vs. 37 (36, 40) fl, Z=4.02, P<0.001) and mean 
      platelet volume (11 (10, 11) vs. 10 (9, 11) fl, Z=2.81, P=0.005) levels. After 
      adjusting for confounding factors such as sex and age, LY (OR=0.42, 95%CI 
      0.29-0.62, P<0.001), WBC (OR=0.75, 95%CI 0.59-0.95, P=0.015), MCHC (OR=0.94, 
      95%CI 0.91-0.97, P<0.001) were independent negative correlation factors of VVS, 
      while MCV (OR=1.08, 95%CI 1.01-1.15, P=0.021) was independent positive 
      correlation factor. ROC curve showed that the combination of LY, WBC, MCV and 
      MCHC had acceptable predictive value for the diagnosis of VVS, with area under 
      curve of 0.88, sensitivity of 0.80, specificity of 0.83, and Youden index of 
      0.63. Conclusions: Compared with healthy children, the blood cell parameters 
      usually change in those with VVS. Combination of LY, WBC, MCHC and MCV can 
      facilitate the diagnosis of VVS in children with unexplained syncope or 
      prodromata.
FAU - Zhang, J
AU  - Zhang J
AD  - Department of Pediatric Cardiovascular, Children's Medical Center,the Second 
      Xiangya Hospital, Central South University, Changsha 410011, China.
FAU - Tang, H N
AU  - Tang HN
AD  - Department of Laboratory Medicine, the Second Xiangya Hospital, Central South 
      University, Changsha 410011, China.
FAU - Wang, Y W
AU  - Wang YW
AD  - Department of Pediatric Cardiovascular, Children's Medical Center,the Second 
      Xiangya Hospital, Central South University, Changsha 410011, China.
FAU - Li, F
AU  - Li F
AD  - Department of Pediatric Cardiovascular, Children's Medical Center,the Second 
      Xiangya Hospital, Central South University, Changsha 410011, China.
FAU - Cai, H
AU  - Cai H
AD  - Department of Pediatric Cardiovascular, Children's Medical Center,the Second 
      Xiangya Hospital, Central South University, Changsha 410011, China.
FAU - Lin, P
AU  - Lin P
AD  - Department of Pediatric Cardiovascular, Children's Medical Center,the Second 
      Xiangya Hospital, Central South University, Changsha 410011, China.
FAU - Zou, R M
AU  - Zou RM
AD  - Department of Pediatric Cardiovascular, Children's Medical Center,the Second 
      Xiangya Hospital, Central South University, Changsha 410011, China.
FAU - Wang, C
AU  - Wang C
AD  - Department of Pediatric Cardiovascular, Children's Medical Center,the Second 
      Xiangya Hospital, Central South University, Changsha 410011, China.
LA  - chi
GR  - 2020SK53405/Hunan Province Clinical Medical Technology Innovation Guidance 
      Project/
PT  - Journal Article
PL  - China
TA  - Zhonghua Er Ke Za Zhi
JT  - Zhonghua er ke za zhi = Chinese journal of pediatrics
JID - 0417427
SB  - IM
MH  - Case-Control Studies
MH  - Child
MH  - Female
MH  - Humans
MH  - Lymphocytes
MH  - Male
MH  - Syncope
MH  - *Syncope, Vasovagal/diagnosis
MH  - Tilt-Table Test
EDAT- 2022/08/04 06:00
MHDA- 2022/08/06 06:00
CRDT- 2022/08/03 21:44
PHST- 2022/08/03 21:44 [entrez]
PHST- 2022/08/04 06:00 [pubmed]
PHST- 2022/08/06 06:00 [medline]
AID - 10.3760/cma.j.cn112140-20220129-00098 [doi]
PST - ppublish
SO  - Zhonghua Er Ke Za Zhi. 2022 Aug 2;60(8):792-797. doi: 
      10.3760/cma.j.cn112140-20220129-00098.