PMID- 35925033
OWN - NLM
STAT- MEDLINE
DCOM- 20220808
LR  - 20220808
IS  - 0189-160X (Print)
IS  - 0189-160X (Linking)
VI  - 39
IP  - 7
DP  - 2022 Jul 31
TI  - Serum Immunoglobulin E and Vitamin D Levels in Asthma Patients in Enugu, Nigeria: 
      Association with Asthma Control.
PG  - 721-728
AB  - BACKGROUND: Asthma symptoms are often mediated by changes in immune responses to 
      allergens measured by the levels of immunoglobulin E (IgE) and non-protein 
      regulators such as 25-hydroxycholecalciferol (25 (OH) vitamin D3). The 
      relationship between serum levels of IgE, 25 (OH) Vitamin D3, and asthma control 
      in asthma patients remains unclear. OBJECTIVE: To measure the serum IgE and 25 
      (OH) vitamin D3 levels in asthma patients and determine their relationship with 
      patient's asthma control. METHODS: This was a cross-sectional study of children 
      and adults with asthma aged 5 to 60 years old; and their controls seen in a 
      tertiary hospital in Enugu, south eastern Nigeria from October 2018 to January 
      2019. Serum levels of IgE, and 25 (OH) vitamin D3 were determined by sandwich 
      enzyme-linked immunosorbent assay (ELISA); and compared between groups using the 
      Student's t-tests. Association between IgE, 25 (OH) vitamin D3 levels, and asthma 
      control were determined using the Chi-square. RESULTS: Sixty-five (65) asthma 
      patients and thirty-three (36) non-asthma controls were studied. Mean serum level 
      of IgE (411.32+/- 220.18 IU/ml) was significantly raised in asthma patients 
      compared to controls (163.51 +/- 186.36 lU/ml); p=0.001. There was no significant 
      difference in mean 25 (OH) vitamin D3 levels in asthma (68.55 +/- 25.91 ng/ml) 
      compared to controls (77.25 +/- 34.01 ng/ml); p=0.153. No significant association 
      was found between patient's asthma control status, and serum IgE and 25 (OH) 
      vitamin D3 levels. CONCLUSION: Asthma control status was not associated with 
      Immunoglobulin E and 25 (OH) vitamin D3 levels in those studied. More robust 
      study is required to evaluate the relationship between asthma control, IgE and 
      vitamin D levels.
CI  - Copyright (c) 2022 by West African Journal of Medicine.
FAU - Ibegbu, M D
AU  - Ibegbu MD
AD  - Department of Medical Biochemistry, Faculty of Basic Medical Sciences, College of 
      Medicine, University of Nigeria, Enugu Campus, Nigeria.
FAU - Ebulue, C E
AU  - Ebulue CE
AD  - Department of Medical Biochemistry, Faculty of Basic Medical Sciences, College of 
      Medicine, University of Nigeria, Enugu Campus, Nigeria.
FAU - Eze, J N
AU  - Eze JN
AD  - Department of Paediatrics, Faculty of Medical Sciences, College of Medicine, 
      University of Nigeria, Enugu State, Nigeria.
FAU - Ndubuisi, C A
AU  - Ndubuisi CA
AD  - Department of Medical Biochemistry, Faculty of Basic Medical Sciences, College of 
      Medicine, University of Nigeria, Enugu Campus, Nigeria.
FAU - Orji, O C
AU  - Orji OC
AD  - Department of Medical Laboratory Sciences, Faculty of Health Sciences, College of 
      Medicine, University of Nigeria, Enugu Campus, Nigeria.
FAU - Ikekpeazu, J E
AU  - Ikekpeazu JE
AD  - Department of Medical Biochemistry, Faculty of Basic Medical Sciences, College of 
      Medicine, University of Nigeria, Enugu Campus, Nigeria.
FAU - Onyedum, C C
AU  - Onyedum CC
AD  - Department of Medicine, Faculty of Medical Sciences, College of Medicine, 
      University of Nigeria, Enugu State, Nigeria.
LA  - eng
PT  - Journal Article
PL  - Nigeria
TA  - West Afr J Med
JT  - West African journal of medicine
JID - 8301891
RN  - 1406-16-2 (Vitamin D)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - P6YZ13C99Q (Calcifediol)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Asthma
MH  - Calcifediol
MH  - Child
MH  - Child, Preschool
MH  - Cross-Sectional Studies
MH  - Humans
MH  - Immunoglobulin E
MH  - Middle Aged
MH  - Nigeria
MH  - *Vitamin D
MH  - Young Adult
OTO - NOTNLM
OT  - 25 hydroxyl vitamin D3
OT  - Asthma control
OT  - Children
OT  - Immunoglobulin E
COIS- The Authors declare that no competing interest exists.
EDAT- 2022/08/05 06:00
MHDA- 2022/08/09 06:00
CRDT- 2022/08/04 10:33
PHST- 2022/08/04 10:33 [entrez]
PHST- 2022/08/05 06:00 [pubmed]
PHST- 2022/08/09 06:00 [medline]
AID - West Afr J Med. 2022 July; 39 (7): 721-728 [pii]
PST - ppublish
SO  - West Afr J Med. 2022 Jul 31;39(7):721-728.