PMID- 35925433
OWN - NLM
STAT- MEDLINE
DCOM- 20230501
LR  - 20230501
IS  - 1573-2983 (Electronic)
IS  - 0269-4042 (Linking)
VI  - 45
IP  - 5
DP  - 2023 May
TI  - The effects of metals and mixture exposure on lung function and the potential 
      mediating effects of oxidative stress.
PG  - 2263-2275
LID - 10.1007/s10653-022-01339-0 [doi]
AB  - Exposure to metals is associated with lung function decline. However, limited 
      data are available about effects of co-exposure of metals on lung function. 
      Additionally, the mechanism of the association between metals and lung function 
      remains unclear. We conducted a longitudinal panel study in 2017-2018 among 45 
      healthy college students. Urinary 15 metals, lung function, biomarkers of 
      oxidative stress and inflammation of participants were measured. Linear mixed 
      effect (LME) and Bayesian kernel machine regression (BKMR) models were applied to 
      explore the associations of urinary metals and mixture with lung function. 
      Furthermore, we analyzed the mediating effect of biomarkers in the association 
      between urinary metals and lung function. LME models showed the negative 
      associations of aluminum (Al), vanadium (V), manganese (Mn), cobalt (Co), nickel 
      (Ni), cadmium (Cd) or antimony (Sb) with Forced vital capacity (FVC), and V, Co, 
      Ni, and Sb with Forced expiratory volume in one second (FEV1). BKMR models 
      indicated the overall effect of metals mixture was negatively associated with 
      FEV1 and FVC; urinary Sb was identified as the major contributor to decreased FVC 
      and FEV1. Urinary 8-hydroxydeoxyguanosine mediated the association of Al, Mn, or 
      Sb with FVC and the relationship of V with FEV1. The results revealed the 
      longitudinal dose-response relationships of urinary metals with pulmonary 
      function among healthy adults. Oxidative stress may be the underlying mechanisms 
      of metals exposure associated with decreased lung function. Due to the small 
      sample size, the interpretation of the results of this study should be cautious, 
      and more studies are needed to verify the findings of this study.
CI  - (c) 2022. The Author(s), under exclusive licence to Springer Nature B.V.
FAU - Zeng, Hao
AU  - Zeng H
AD  - Affiliated Huaihe Hospital, Henan University, 115 Ximen street, Kaifeng, 475000, 
      Henan, China.
AD  - School of Public Health, North China University of Science and Technology, No.21 
      Bohai Road, Caofeidian, Tangshan, 063210, Hebei, China.
FAU - Dong, Bohua
AU  - Dong B
AD  - Affiliated Hospital, North China University of Science and Technology, Tangshan, 
      063000, China.
FAU - Wang, Nan
AU  - Wang N
AD  - School of Public Health, North China University of Science and Technology, No.21 
      Bohai Road, Caofeidian, Tangshan, 063210, Hebei, China.
FAU - Xu, Wenzhe
AU  - Xu W
AD  - Tangshan Environmental Monitoring Center, No.54, Jianshe North Road, Lubei, 
      Tangshan, 063210, Hebei, China.
FAU - Guo, Linan
AU  - Guo L
AD  - School of Public Health, North China University of Science and Technology, No.21 
      Bohai Road, Caofeidian, Tangshan, 063210, Hebei, China.
FAU - Liu, Jiajia
AU  - Liu J
AD  - Department of Environmental Health, School of Public Health, China Medical 
      University, No.77 Puhe Road, Shenyang North New Area, Shenyang, Liaoning, China.
FAU - Fang, Bo
AU  - Fang B
AD  - Affiliated Huaihe Hospital, Henan University, 115 Ximen street, Kaifeng, 475000, 
      Henan, China.
FAU - Zhang, Lei
AU  - Zhang L
AD  - Department of Occupational Health and Environmental Health, School of Public 
      Health, Capital Medical University, Beijing, 100069, China.
FAU - Wang, Qian
AU  - Wang Q
AD  - School of Public Health, North China University of Science and Technology, No.21 
      Bohai Road, Caofeidian, Tangshan, 063210, Hebei, China. wwqq517@126.com.
FAU - Yang, Wenqi
AU  - Yang W
AD  - Affiliated Hospital, North China University of Science and Technology, Tangshan, 
      063000, China.
FAU - Wang, Manman
AU  - Wang M
AD  - School of Public Health, North China University of Science and Technology, No.21 
      Bohai Road, Caofeidian, Tangshan, 063210, Hebei, China.
LA  - eng
GR  - No. 82073608/National Natural Science Foundation of China/
GR  - No. H2021209054/Natural Science Foundation of Hebei Province/
PT  - Journal Article
DEP - 20220804
PL  - Netherlands
TA  - Environ Geochem Health
JT  - Environmental geochemistry and health
JID - 8903118
RN  - 0 (Metals)
RN  - 3G0H8C9362 (Cobalt)
RN  - 0 (Biomarkers)
RN  - 42Z2K6ZL8P (Manganese)
RN  - 7OV03QG267 (Nickel)
RN  - CPD4NFA903 (Aluminum)
SB  - IM
MH  - Adult
MH  - Humans
MH  - Bayes Theorem
MH  - *Metals/toxicity
MH  - *Lung
MH  - Cobalt/toxicity
MH  - Biomarkers
MH  - Manganese
MH  - Nickel/toxicity
MH  - Aluminum
MH  - Oxidative Stress
OTO - NOTNLM
OT  - Bayesian kernel machine regression
OT  - Lung function
OT  - Mediating effect
OT  - Metal exposure
OT  - Oxidative stress
EDAT- 2022/08/05 06:00
MHDA- 2023/05/01 06:41
CRDT- 2022/08/04 11:20
PHST- 2022/03/07 00:00 [received]
PHST- 2022/07/17 00:00 [accepted]
PHST- 2023/05/01 06:41 [medline]
PHST- 2022/08/05 06:00 [pubmed]
PHST- 2022/08/04 11:20 [entrez]
AID - 10.1007/s10653-022-01339-0 [pii]
AID - 10.1007/s10653-022-01339-0 [doi]
PST - ppublish
SO  - Environ Geochem Health. 2023 May;45(5):2263-2275. doi: 
      10.1007/s10653-022-01339-0. Epub 2022 Aug 4.