PMID- 35926651
OWN - NLM
STAT- MEDLINE
DCOM- 20221010
LR  - 20221222
IS  - 1873-2968 (Electronic)
IS  - 0006-2952 (Linking)
VI  - 204
DP  - 2022 Oct
TI  - mTOR participates in the formation, maintenance, and function of memory CD8(+)T 
      cells regulated by glycometabolism.
PG  - 115197
LID - S0006-2952(22)00291-X [pii]
LID - 10.1016/j.bcp.2022.115197 [doi]
AB  - Memory CD8(+)T cells participate in the fight against infection and tumorigenesis 
      as well as in autoimmune disease progression because of their efficient and rapid 
      immune response, long-term survival, and continuous differentiation. At each 
      stage of their formation, maintenance, and function, the cell metabolism must be 
      adjusted to match the functional requirements of the specific stage. Notably, 
      enhanced glycolytic metabolism can generate sufficient levels of adenosine 
      triphosphate (ATP) to form memory CD8(+)T cells, countering the view that 
      glycolysis prevents the formation of memory CD8(+)T cells. This review focuses on 
      how glycometabolism regulates memory CD8(+)T cells and highlights the key 
      mechanisms through which the mammalian target of rapamycin (mTOR) signaling 
      pathway affects memory CD8(+)T cell formation, maintenance, and function by 
      regulating glycometabolism. In addition, different subpopulations of memory 
      CD8(+)T cells exhibit different metabolic flexibility during their formation, 
      survival, and functional stages, during which the energy metabolism may be 
      critical. These findings which may explain why enhanced glycolytic metabolism can 
      give rise to memory CD8(+)T cells. Modulating the metabolism of memory CD8(+)T 
      cells to influence specific cell fates may be useful for disease treatment.
CI  - Copyright (c) 2022. Published by Elsevier Inc.
FAU - Cai, Xuepei
AU  - Cai X
AD  - Department of Orthodontics, Stomatological Hospital, Southern Medical University, 
      Guangzhou, China.
FAU - Li, Haokun
AU  - Li H
AD  - Department of Immunology, School of Basic Medical Sciences, Southern Medical 
      University, Guangzhou, China.
FAU - Wang, Manyi
AU  - Wang M
AD  - Department of Orthodontics, Stomatological Hospital, Southern Medical University, 
      Guangzhou, China.
FAU - Chu, Edward
AU  - Chu E
AD  - Department of Oncology and Cancer Therapeutics Program, Albert Einstein Cancer 
      Center, Albert Einstein College of Medicine, Bronx, NY, USA.
FAU - Wei, Ning
AU  - Wei N
AD  - Department of Oncology and Cancer Therapeutics Program, Albert Einstein Cancer 
      Center, Albert Einstein College of Medicine, Bronx, NY, USA.
FAU - Lin, Jiayu
AU  - Lin J
AD  - Department of Orthodontics, Stomatological Hospital, Southern Medical University, 
      Guangzhou, China.
FAU - Hu, Yun
AU  - Hu Y
AD  - Department of Orthodontics, Stomatological Hospital, Southern Medical University, 
      Guangzhou, China.
FAU - Dai, Jingtao
AU  - Dai J
AD  - Department of Orthodontics, Stomatological Hospital, Southern Medical University, 
      Guangzhou, China.
FAU - Chen, Aijie
AU  - Chen A
AD  - Stomatological Hospital, Southern Medical University, Guangzhou, China.
FAU - Zheng, Hua
AU  - Zheng H
AD  - Department of Cardiology, Nanfang Hospital, Southern Medical University, 
      Guangzhou, China.
FAU - Zhang, Qianbing
AU  - Zhang Q
AD  - Cancer Research Institute, School of Basic Medical Sciences, Southern Medical 
      University, Guangzhou, China.
FAU - Zhong, Yuxia
AU  - Zhong Y
AD  - Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, 
      Southern Medical University, Guangzhou, China.
FAU - Chang, Ruoshui
AU  - Chang R
AD  - Department of Immunology, School of Basic Medical Sciences, Southern Medical 
      University, Guangzhou, China.
FAU - Wu, Sha
AU  - Wu S
AD  - Department of Immunology, School of Basic Medical Sciences, Microbiome Medicine 
      Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical 
      University, Guangzhou, China; Key Laboratory of Functional Proteomics of 
      Guangdong Province, Guangzhou, China; National Demonstration Center for 
      Experimental Education of Basic Medical Sciences of China, Guangzhou, China. 
      Electronic address: shawu99@outlook.com.
FAU - Xiao, Yaomu
AU  - Xiao Y
AD  - Department of Orthodontics, Stomatological Hospital, Southern Medical University, 
      Guangzhou, China. Electronic address: cicely0201@smu.edu.cn.
FAU - Liu, Chufeng
AU  - Liu C
AD  - Department of Orthodontics, Stomatological Hospital, Southern Medical University, 
      Guangzhou, China. Electronic address: xyzmmok@smu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20220801
PL  - England
TA  - Biochem Pharmacol
JT  - Biochemical pharmacology
JID - 0101032
RN  - 8L70Q75FXE (Adenosine Triphosphate)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Adenosine Triphosphate/metabolism
MH  - Animals
MH  - CD8-Positive T-Lymphocytes
MH  - Cell Differentiation
MH  - Glycolysis
MH  - *Immunologic Memory
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - *TOR Serine-Threonine Kinases/metabolism
OTO - NOTNLM
OT  - Glycolysis
OT  - Glycometabolism
OT  - Memory CD8(+)T cell
OT  - mTOR
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2022/08/05 06:00
MHDA- 2022/10/12 06:00
CRDT- 2022/08/04 19:23
PHST- 2022/05/30 00:00 [received]
PHST- 2022/07/21 00:00 [revised]
PHST- 2022/07/27 00:00 [accepted]
PHST- 2022/08/05 06:00 [pubmed]
PHST- 2022/10/12 06:00 [medline]
PHST- 2022/08/04 19:23 [entrez]
AID - S0006-2952(22)00291-X [pii]
AID - 10.1016/j.bcp.2022.115197 [doi]
PST - ppublish
SO  - Biochem Pharmacol. 2022 Oct;204:115197. doi: 10.1016/j.bcp.2022.115197. Epub 2022 
      Aug 1.