PMID- 35926759
OWN - NLM
STAT- MEDLINE
DCOM- 20220909
LR  - 20220909
IS  - 1873-3441 (Electronic)
IS  - 0939-6411 (Linking)
VI  - 178
DP  - 2022 Sep
TI  - Mucopenetration study of solid lipid nanoparticles containing magneto sensitive 
      iron oxide.
PG  - 94-104
LID - S0939-6411(22)00155-2 [pii]
LID - 10.1016/j.ejpb.2022.07.017 [doi]
AB  - In most chronic respiratory diseases, excessive viscous airway secretions oppose 
      a formidable permeation barrier to drug delivery systems (DDSs), with a limit to 
      their therapeutic efficacy for the targeting epithelium. Since mucopenetration of 
      DDSs with slippery technology (i.e. PEGylation) has encountered a reduction in 
      the presence of sticky and complex airway secretions, our aim was to evaluate the 
      relevance of magnetic PEGylated Solid Lipid Nanoparticles (mSLNs) for pulling 
      them through chronic obstructive pulmonary disease (COPD) airway secretions. 
      Thus, COPD sputum from outpatient clinic, respiratory secretions aspirated from 
      high (HI) and low (LO) airways of COPD patients in acute respiratory 
      insufficiency, and porcine gastric mucus (PGM) were investigated for their 
      permeability to mSLN particles under a magnetic field. Rheological tests and mSLN 
      adhesion to airway epithelial cells (AECs) were also investigated. The results of 
      mucopenetration show that mSLNs are permeable both in COPD sputum and in PGM, 
      while HI and LO secretions are always impervious. Parallel rheological results 
      show a different elastic property, which can be associated with different mucus 
      mesostructures. Finally, adhesion tests confirm the role of the magnetic field in 
      improving the interaction of SLNs with AECs. Overall, our results reveal that 
      mesostructure is of paramount importance in determining the mucopenetration of 
      magnetic SLNs.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Castellani, Stefano
AU  - Castellani S
AD  - Department of Biomedical Sciences and Human Oncology, University of Bari "Aldo 
      Moro", Italy.
FAU - Trapani, Adriana
AU  - Trapani A
AD  - Department of Pharmacy-Drug Sciences, University of Bari "Aldo Moro", Bari, 
      Italy.
FAU - Elisiana Carpagnano, Giovanna
AU  - Elisiana Carpagnano G
AD  - Department of Basic Medical Science, Neuroscience and Sense Organs, University of 
      Bari 'Aldo Moro', Bari, Italy.
FAU - Cotoia, Antonella
AU  - Cotoia A
AD  - Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.
FAU - Laselva, Onofrio
AU  - Laselva O
AD  - Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.
FAU - Pia Foschino Barbaro, Maria
AU  - Pia Foschino Barbaro M
AD  - Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.
FAU - Corbo, Filomena
AU  - Corbo F
AD  - Department of Pharmacy-Drug Sciences, University of Bari "Aldo Moro", Bari, 
      Italy.
FAU - Cinnella, Gilda
AU  - Cinnella G
AD  - Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.
FAU - De Giglio, Elvira
AU  - De Giglio E
AD  - Department of Chemistry, University of Bari "Aldo Moro", Bari, Italy.
FAU - Larobina, Domenico
AU  - Larobina D
AD  - Institute of Polymers, Composites and Biomaterials - National Research Council of 
      Italy, Portici (Naples), Italy.
FAU - Di Gioia, Sante
AU  - Di Gioia S
AD  - Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.
FAU - Conese, Massimo
AU  - Conese M
AD  - Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy. 
      Electronic address: massimo.conese@unifg.it.
LA  - eng
PT  - Journal Article
DEP - 20220802
PL  - Netherlands
TA  - Eur J Pharm Biopharm
JT  - European journal of pharmaceutics and biopharmaceutics : official journal of 
      Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
JID - 9109778
RN  - 0 (Ferric Compounds)
RN  - 0 (Lipid Nanoparticles)
RN  - 0 (Liposomes)
RN  - 1K09F3G675 (ferric oxide)
SB  - IM
MH  - Animals
MH  - Ferric Compounds
MH  - Liposomes
MH  - Mucus
MH  - *Nanoparticles/chemistry
MH  - *Pulmonary Disease, Chronic Obstructive/drug therapy
MH  - Swine
OTO - NOTNLM
OT  - Airway epithelial cells
OT  - Magnetic field
OT  - Mucopenetration
OT  - Rheometry
OT  - Solid lipid nanoparticles
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2022/08/05 06:00
MHDA- 2022/09/11 06:00
CRDT- 2022/08/04 19:26
PHST- 2022/04/21 00:00 [received]
PHST- 2022/07/19 00:00 [revised]
PHST- 2022/07/28 00:00 [accepted]
PHST- 2022/08/05 06:00 [pubmed]
PHST- 2022/09/11 06:00 [medline]
PHST- 2022/08/04 19:26 [entrez]
AID - S0939-6411(22)00155-2 [pii]
AID - 10.1016/j.ejpb.2022.07.017 [doi]
PST - ppublish
SO  - Eur J Pharm Biopharm. 2022 Sep;178:94-104. doi: 10.1016/j.ejpb.2022.07.017. Epub 
      2022 Aug 2.