PMID- 35926826
OWN - NLM
STAT- MEDLINE
DCOM- 20221004
LR  - 20221214
IS  - 1878-5832 (Electronic)
IS  - 1359-6446 (Linking)
VI  - 27
IP  - 10
DP  - 2022 Oct
TI  - Current and future approaches for in vitro hit discovery in diabetes mellitus.
PG  - 103331
LID - S1359-6446(22)00301-4 [pii]
LID - 10.1016/j.drudis.2022.07.016 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is a serious public health problem. In this 
      review, we discuss current and promising future drugs, targets, in vitro assays 
      and emerging omics technologies in T2DM. Importantly, we open the perspective to 
      image-based high-content screening (HCS), with the focus of combining it with 
      metabolomics or lipidomics. HCS has become a strong technology in phenotypic 
      screens because it allows comprehensive screening for the cell-modulatory 
      activity of small molecules. Metabolomics and lipidomics screen for perturbations 
      at the molecular level. The combination of these data-intensive comprehensive 
      technologies is enabled by the rapid development of artificial intelligence. It 
      promises a deep cellular and molecular phenotyping directly linked to chemical 
      information about the applied drug candidates or complex mixtures.
CI  - Copyright (c) 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Zhang, Xin
AU  - Zhang X
AD  - Research Unit Analytical BioGeoChemistry, Helmholtz Zentrum Munchen, 
      Ingolstaedter Landstr. 1, 85764 Neuherberg, Germany.
FAU - Kupczyk, Erwin
AU  - Kupczyk E
AD  - Research Unit Analytical BioGeoChemistry, Helmholtz Zentrum Munchen, 
      Ingolstaedter Landstr. 1, 85764 Neuherberg, Germany; Comprehensive Foodomics 
      Platform, Chair of Analytical Food Chemistry, TUM School of Life Sciences, 
      Technical University of Munich, Maximus-von-Imhof-Forum 2, 85354 Freising, 
      Germany.
FAU - Schmitt-Kopplin, Philippe
AU  - Schmitt-Kopplin P
AD  - Research Unit Analytical BioGeoChemistry, Helmholtz Zentrum Munchen, 
      Ingolstaedter Landstr. 1, 85764 Neuherberg, Germany; Comprehensive Foodomics 
      Platform, Chair of Analytical Food Chemistry, TUM School of Life Sciences, 
      Technical University of Munich, Maximus-von-Imhof-Forum 2, 85354 Freising, 
      Germany. Electronic address: schmitt-kopplin@helmholtz-muenchen.de.
FAU - Mueller, Constanze
AU  - Mueller C
AD  - Research Unit Analytical BioGeoChemistry, Helmholtz Zentrum Munchen, 
      Ingolstaedter Landstr. 1, 85764 Neuherberg, Germany. Electronic address: 
      constanze.mueller@helmholtz-muenchen.de.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20220801
PL  - England
TA  - Drug Discov Today
JT  - Drug discovery today
JID - 9604391
RN  - 0 (Complex Mixtures)
SB  - IM
MH  - Artificial Intelligence
MH  - Complex Mixtures
MH  - *Diabetes Mellitus, Type 2/drug therapy
MH  - Humans
MH  - Metabolomics
OTO - NOTNLM
OT  - Bioactives
OT  - Cell painting
OT  - Drug discovery
OT  - Functional metabolomics
OT  - High-content screening
OT  - Lipidomics
EDAT- 2022/08/05 06:00
MHDA- 2022/10/05 06:00
CRDT- 2022/08/04 19:27
PHST- 2022/02/04 00:00 [received]
PHST- 2022/06/10 00:00 [revised]
PHST- 2022/07/26 00:00 [accepted]
PHST- 2022/08/05 06:00 [pubmed]
PHST- 2022/10/05 06:00 [medline]
PHST- 2022/08/04 19:27 [entrez]
AID - S1359-6446(22)00301-4 [pii]
AID - 10.1016/j.drudis.2022.07.016 [doi]
PST - ppublish
SO  - Drug Discov Today. 2022 Oct;27(10):103331. doi: 10.1016/j.drudis.2022.07.016. 
      Epub 2022 Aug 1.