PMID- 35927761 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220808 IS - 1758-5996 (Print) IS - 1758-5996 (Electronic) IS - 1758-5996 (Linking) VI - 14 IP - 1 DP - 2022 Aug 4 TI - Circulating osteocalcin is associated with time in range and other metrics assessed by continuous glucose monitoring in type 2 diabetes. PG - 109 LID - 10.1186/s13098-022-00863-4 [doi] LID - 109 AB - BACKGROUND: Osteocalcin, a protein secreted mainly by mature osteoblasts, has been shown to be involved in glucose metabolism through various pathways. However, few studies has explored the association between osteocalcin and Time in range (TIR). Continuous glucose monitoring (CGM) -derived metrics, such as TIR and other indexes have been gradually and widely used in clinical practice to assess glucose fluctuations. The main purpose of this study was to investigate the correlation between osteocalcin and indexes from CGM in patients with type 2 diabetes mellitus (T2DM). METHOD: The total number of 376 patients with T2D were enrolled, all of them performed three consecutive days of monitoring. They were divided into four groups on account of the quartile of osteocalcin. Time in range, Time below range (TBR), Time above range(TAR) and measures of glycemic variability (GV) were assessed for analysing. After a 100 g standard steamed bread meal, blood glucose (Glu0h Glu0.5 h, Glu1h, Glu2h, GLu3h), C-peptide (Cp0h, Cp0.5 h, Cp1h, Cp2h, Cp3h), serum insulin (INS0h, INS0.5 h, INS1h, INS2h, INS3h) concentrations at different time points were obtained. HOMA-IS, HOMA-betawas calculated to evaluate insulin sensitivity and insulin secreting of the participants. RESULTS: Patients with higher osteocalcin level had higher TIR (P < 0.05). Spearman correlation analysis showed that osteocalcin was positively correlated with TBR (although the P value for TBR was greater than 0.05) (r = 0.227, P < 0.001 r = 0.068, P = 0.189) and negatively correlated with TAR (- 0.229, P < 0.001). Similarly, there was a negative correlation between osteocalcin and glycemic variability (GV) indicators, including SD, MBG, MODD, ADDR, and MAGE (P value of MAGE > 0.05). Multiple stepwise regression showed that osteocalcin was an independent contributor to TIR, TAR and HOMA-IS. CONCLUSION: Circulating osteocalcin is positively correlated with TIR and negatively correlated with MODD, ADDR, and MAGE. Osteocalcin may have a beneficial impact on glucose homeostasis in T2DM patients. CI - (c) 2022. The Author(s). FAU - Liu, Jun AU - Liu J AD - Department of Endocrinology, Jinling Hospital, Southern Medical University, Nanjing, China. FAU - Wei, Yinghua AU - Wei Y AD - Department of Endocrinology, School of Medicine, Jinling Hospital, Nanjing University, Nanjing, China. FAU - Zang, Pu AU - Zang P AD - Department of Endocrinology, School of Medicine, Jinling Hospital, Nanjing University, Nanjing, China. FAU - Wang, Wei AU - Wang W AD - Department of Endocrinology, School of Medicine, Jinling Hospital, Nanjing University, Nanjing, China. FAU - Feng, Zhouqin AU - Feng Z AD - Department of Endocrinology, Jinling Hospital, Southern Medical University, Nanjing, China. FAU - Yuan, Yanyu AU - Yuan Y AD - Department of Endocrinology, Jinling Hospital, Nanjing Medical University, Nanjing, China. FAU - Zhou, Hui AU - Zhou H AD - Department of Endocrinology, Jinling Hospital, Southern Medical University, Nanjing, China. FAU - Zhang, Zhen AU - Zhang Z AD - Department of Endocrinology, Jinling Hospital, Southern Medical University, Nanjing, China. FAU - Lei, Haiyan AU - Lei H AD - Department of Endocrinology, Jinling Hospital, Southern Medical University, Nanjing, China. FAU - Yang, Xinyi AU - Yang X AD - Department of Endocrinology, School of Medicine, Jinling Hospital, Nanjing University, Nanjing, China. FAU - Liu, Jun AU - Liu J AD - Department of Endocrinology, Jinling Hospital, Nanjing Medical University, Nanjing, China. FAU - Lu, Bin AU - Lu B AD - Department of Endocrinology, School of Medicine, Jinling Hospital, Nanjing University, Nanjing, China. yearinyearout@126.com. FAU - Shao, Jiaqing AU - Shao J AD - Department of Endocrinology, Jinling Hospital, Southern Medical University, Nanjing, China. shaojiaqing@nju.edu.cn. LA - eng GR - 81873174/National Natural Science Foundation of China/ GR - 81873174/National Natural Science Foundation of China/ GR - 81873174/National Natural Science Foundation of China/ GR - 81873174/National Natural Science Foundation of China/ GR - 81873174/National Natural Science Foundation of China/ GR - 81873174/National Natural Science Foundation of China/ GR - 81873174/National Natural Science Foundation of China/ GR - 81873174/National Natural Science Foundation of China/ GR - 81873174/National Natural Science Foundation of China/ GR - 81873174/National Natural Science Foundation of China/ GR - 81873174/National Natural Science Foundation of China/ GR - 81873174/National Natural Science Foundation of China/ GR - 81873174/National Natural Science Foundation of China/ GR - BE2020701/Key Research and Development Plan Project of Jiangsu Province - Social Development Projects./ GR - BE2020701/Key Research and Development Plan Project of Jiangsu Province - Social Development Projects./ GR - BE2020701/Key Research and Development Plan Project of Jiangsu Province - Social Development Projects./ GR - BE2020701/Key Research and Development Plan Project of Jiangsu Province - Social Development Projects./ GR - BE2020701/Key Research and Development Plan Project of Jiangsu Province - Social Development Projects./ GR - BE2020701/Key Research and Development Plan Project of Jiangsu Province - Social Development Projects./ GR - BE2020701/Key Research and Development Plan Project of Jiangsu Province - Social Development Projects./ GR - BE2020701/Key Research and Development Plan Project of Jiangsu Province - Social Development Projects./ GR - BE2020701/Key Research and Development Plan Project of Jiangsu Province - Social Development Projects./ GR - BE2020701/Key Research and Development Plan Project of Jiangsu Province - Social Development Projects./ GR - BE2020701/Key Research and Development Plan Project of Jiangsu Province - Social Development Projects./ GR - BE2020701/Key Research and Development Plan Project of Jiangsu Province - Social Development Projects./ GR - BE2020701/Key Research and Development Plan Project of Jiangsu Province - Social Development Projects./ PT - Journal Article DEP - 20220804 PL - England TA - Diabetol Metab Syndr JT - Diabetology & metabolic syndrome JID - 101488958 PMC - PMC9351112 OTO - NOTNLM OT - Glycemic control OT - HOMA-IS OT - Osteocalcin OT - Time in range OT - Type 2 diabetes COIS- There are no conflicts of interest. EDAT- 2022/08/05 06:00 MHDA- 2022/08/05 06:01 PMCR- 2022/08/04 CRDT- 2022/08/04 23:51 PHST- 2022/02/20 00:00 [received] PHST- 2022/06/13 00:00 [accepted] PHST- 2022/08/04 23:51 [entrez] PHST- 2022/08/05 06:00 [pubmed] PHST- 2022/08/05 06:01 [medline] PHST- 2022/08/04 00:00 [pmc-release] AID - 10.1186/s13098-022-00863-4 [pii] AID - 863 [pii] AID - 10.1186/s13098-022-00863-4 [doi] PST - epublish SO - Diabetol Metab Syndr. 2022 Aug 4;14(1):109. doi: 10.1186/s13098-022-00863-4.