PMID- 35927883
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220805
IS  - 2151-3228 (Electronic)
IS  - 2151-321X (Linking)
VI  - 24
IP  - 2
DP  - 2011
TI  - Negative Atopy Patch Test and Negative Skin Prick Test Reduce the Need for Oral 
      Food Challenge in Children with Atopic Dermatitis.
PG  - 107-112
LID - 10.1089/ped.2010.0044 [doi]
AB  - Atopic dermatitis (AD) is commonly associated with food allergy. Oral food 
      challenge is the gold standard in the diagnosis of food allergy, but still has 
      some troubles. The aim of this study was to evaluate whether a single test among 
      skin prick test (SPT), measurement of specific immunoglobulin E (IgE), and atopy 
      patch test (APT) or a combination of them could make food challenges unnecessary 
      in patients with AD. Twenty patients affected by AD, under 6 years of age, were 
      evaluated. Every child was investigated for cow's milk and hen's egg allergy 
      using SPT, measurement of serum IgE (sIgE), APT, diagnostic elimination diet for 
      4 weeks, and open food challenges for milk and egg. The diagnosis of food allergy 
      was established according to the results of the food challenge. We compared the 
      results of all the tests with those of the open food challenge and calculated for 
      each test the following parameters: sensitivity, specificity, positive predictive 
      value (PPV), and negative predictive value (NPV). Eight of 40 open food 
      challenges were assessed as positive. None of the diagnostic tools showed a 
      sufficient accuracy to be able to replace the food challenge. However, SPT, APT, 
      and the measurement of sIgE as single parameters showed an NPV of 90%, and the 
      combination of SPT and APT showed an NPV of 92%. Food challenge remains the gold 
      standard for food allergy diagnosis in young children with AD, but the 
      combination of SPT and APT is useful when both tests are negative, because this 
      result provides a guidance in excluding an allergy to the investigated food and 
      could make the food challenge superfluous in this case.
FAU - Peron, Angela
AU  - Peron A
AD  - Department of Pediatrics, San Raffaele Hospital, Vita-Salute University IRCCS San 
      Raffaele, Milan, Italy.
FAU - Tenconi, Rossana
AU  - Tenconi R
AD  - Department of Pediatrics, San Raffaele Hospital, Vita-Salute University IRCCS San 
      Raffaele, Milan, Italy.
FAU - Leone, Maddalena
AU  - Leone M
AD  - Department of Pediatrics, Legnano Hospital, Legnano, Milan, Italy.
FAU - Macellaro, Patrizia
AU  - Macellaro P
AD  - Department of Pediatrics, Legnano Hospital, Legnano, Milan, Italy.
FAU - Ceriani, Elena
AU  - Ceriani E
AD  - Department of Pediatrics, Legnano Hospital, Legnano, Milan, Italy.
FAU - d'Arcais, Alberto Flores
AU  - d'Arcais AF
AD  - Department of Pediatrics, San Raffaele Hospital, Vita-Salute University IRCCS San 
      Raffaele, Milan, Italy.
AD  - Department of Pediatrics, Legnano Hospital, Legnano, Milan, Italy.
LA  - eng
PT  - Journal Article
DEP - 20110525
PL  - United States
TA  - Pediatr Allergy Immunol Pulmonol
JT  - Pediatric allergy, immunology, and pulmonology
JID - 101549629
SB  - IM
EDAT- 2011/01/01 00:00
MHDA- 2011/01/01 00:01
CRDT- 2022/08/05 01:05
PHST- 2022/08/05 01:05 [entrez]
PHST- 2011/01/01 00:00 [pubmed]
PHST- 2011/01/01 00:01 [medline]
AID - 10.1089/ped.2010.0044 [doi]
PST - ppublish
SO  - Pediatr Allergy Immunol Pulmonol. 2011;24(2):107-112. doi: 10.1089/ped.2010.0044. 
      Epub 2011 May 25.