PMID- 35928354
OWN - NLM
STAT- MEDLINE
DCOM- 20220808
LR  - 20220822
IS  - 1844-3117 (Electronic)
IS  - 1844-122X (Print)
IS  - 1844-122X (Linking)
VI  - 15
IP  - 6
DP  - 2022 Jun
TI  - The role of renal damage markers in the diagnosis of early stages of kidney 
      injury in patients with latent autoimmune diabetes in adults.
PG  - 792-796
LID - 10.25122/jml-2022-0062 [doi]
AB  - Serum creatinine level begins to increase after a decrease in glomerular 
      filtration rate (GFR) by 50% and more, so the question emerged about a more 
      accurate method of determining GFR. The study aimed to determine the role of 
      renal damage markers in the diagnosis of early-stage renal disease in patients 
      with latent autoimmune diabetes in adults (LADA). We included 84 patients with 
      diabetes mellitus (DM) and chronic kidney disease (CKD) caused by diabetic kidney 
      disease (DKD), as well as 25 representatives of the control group. Patients were 
      divided into three groups - 43 people with LADA, 21 with type 1 diabetes mellitus 
      (T1DM), and 20 patients with type 2 diabetes mellitus (T2DM). GFR was assessed 
      using six formulas after establishing the category of GFR and albuminuria. The 
      GFR rate estimated by the CKD-EPI formula in patients with LADA and DKD did not 
      significantly differ from that of CKD-EPI cysC, slightly different from MDRD GFR 
      (10.6% higher, respectively) but 21.9% lower compared to CG formula. In patients 
      with LADA and T1DM, GFR was higher in cases with existing albuminuria, regardless 
      of the formulas used. Thus, the non albuminuria phenotype is accompanied by a 
      greater degree of renal impairment, which indicates the need to determine serum 
      cystatin C in the early stages of LADA. Cystatin C levels are the most accurate, 
      early, and independent predictor of the development and progression of CKD in 
      patients with DM, including LADA.
CI  - (c)2022 JOURNAL of MEDICINE and LIFE.
FAU - Tsaryk, Iryna
AU  - Tsaryk I
AD  - Department of Clinical Immunology, Allergology and Endocrinology, Bukovinian 
      State Medical University, Chernivtsi, Ukraine.
FAU - Pashkovska, Nataliia
AU  - Pashkovska N
AD  - Department of Clinical Immunology, Allergology and Endocrinology, Bukovinian 
      State Medical University, Chernivtsi, Ukraine.
LA  - eng
PT  - Journal Article
PL  - Romania
TA  - J Med Life
JT  - Journal of medicine and life
JID - 101477617
RN  - 0 (Biomarkers)
RN  - 0 (Cystatin C)
RN  - AYI8EX34EU (Creatinine)
SB  - IM
MH  - Biomarkers/blood
MH  - Creatinine/blood
MH  - *Cystatin C/blood
MH  - *Diabetes Mellitus, Type 1/blood/complications
MH  - *Diabetes Mellitus, Type 2/blood/complications
MH  - Glomerular Filtration Rate
MH  - Humans
MH  - Kidney
MH  - *Latent Autoimmune Diabetes in Adults/blood/complications
MH  - *Renal Insufficiency, Chronic/blood/complications
PMC - PMC9321499
OTO - NOTNLM
OT  - A+ - albuminuria
OT  - A- - normoalbuminuria
OT  - ADA - American diabetes association
OT  - CKD - chronic kidney disease
OT  - DKD - diabetic kidney disease
OT  - DM - diabetes mellitus
OT  - DN - diabetic nephropathy
OT  - GFR - glomerular filtration rate
OT  - LADA - latent autoimmune diabetes in adults
OT  - MAU - microalbuminuria
OT  - T1DM - type 1 diabetes mellitus
OT  - T2DM - type 2 diabetes mellitus
OT  - antiGAD - antibodies to glutamic acid decarboxylase
OT  - chronic kidney disease
OT  - creatinine
OT  - cystatin C
OT  - diabetes mellitus
OT  - glomerular filtration rate
OT  - latent autoimmune diabetes in adults
COIS- The authors declare no conflict of interest.
EDAT- 2022/08/06 06:00
MHDA- 2022/08/09 06:00
PMCR- 2022/08/01
CRDT- 2022/08/05 02:10
PHST- 2022/03/02 00:00 [received]
PHST- 2022/05/10 00:00 [accepted]
PHST- 2022/08/05 02:10 [entrez]
PHST- 2022/08/06 06:00 [pubmed]
PHST- 2022/08/09 06:00 [medline]
PHST- 2022/08/01 00:00 [pmc-release]
AID - JMedLife-15-792 [pii]
AID - 10.25122/jml-2022-0062 [doi]
PST - ppublish
SO  - J Med Life. 2022 Jun;15(6):792-796. doi: 10.25122/jml-2022-0062.