PMID- 35928697
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220806
IS  - 2397-9070 (Electronic)
IS  - 2397-9070 (Linking)
VI  - 6
IP  - 8
DP  - 2022 Aug
TI  - Relationship between active Helicobacter pylori infection and anemia, iron 
      deficiency, iron deficiency anemia: A cross-sectional study in a sub-Saharan 
      setting.
PG  - 554-568
LID - 10.1002/jgh3.12787 [doi]
AB  - BACKGROUND AND AIM: There have been contradictory reports about the association 
      between Helicobacter pylori infection and iron deficiency anemia (IDA). Based on 
      the high frequency of H. pylori infection in Cameroon, we have evaluated the 
      frequency of H. pylori infection as the cause of anemia, and IDA among dyspeptic 
      patients in Cameroon. METHODS: This cross-sectional study enrolled 842 dyspeptic 
      patients (472 women and 370 men) in two reference hospitals in Douala-Cameroon. 
      Each participant gave a written consent, and the study was approved by the 
      National Ethical Committee. Erythroid-related indices and markers of iron 
      deficiency (ID) measurement were done for each participant as well as H. pylori 
      detection. Data were analyzed using SSPS statistical package. RESULTS: The 
      prevalence of anemia, ID, IDA, and H. pylori infection was 65.08%, 31.47%, 
      25.65%, and 80.88%, respectively. H. pylori infected individuals had a 
      significantly lower mean value of hemoglobin (P = 0.01), hematocrit (P = 0.04), 
      ferritin (P = 0.03) and coefficient of transferrin saturation (CTS) levels 
      (P = 0.04) and a significantly higher mean value of mean corpuscular hemoglobin 
      concentration (MCHC) (P = 0.02). Compared with H. pylori non-infected 
      participants, H. pylori infected patients were 1.2938 (95% confidence interval 
      [CI]: 0.9087-1.8421), 1.1851 (95% CI: 0.8122-1.7292), and 1.5636 (95% CI: 
      1.0206-2.3953) times at higher risk to develop anemia, ID, and IDA, respectively. 
      A significant relationship was found between H. pylori infection and IDA 
      (P = 0.04 and 0.04 for crude and age/sex-adjusted, respectively). CONCLUSION: H. 
      pylori infection seems to be associated with anemia, and IDA among dyspeptic 
      patients in our milieu.
CI  - (c) 2022 The Authors. JGH Open published by Journal of Gastroenterology and 
      Hepatology Foundation and John Wiley & Sons Australia, Ltd.
FAU - Eyoum Bille, Bertrand B
AU  - Eyoum Bille BB
AD  - Microbiology and Pharmacology Laboratory, Department of Biochemistry, Faculty of 
      Science University of Dschang Dschang Cameroon.
FAU - Kouitcheu Mabeku, Laure B
AU  - Kouitcheu Mabeku LB
AUID- ORCID: 0000-0002-6447-1413
AD  - Medical Microbiology Laboratory, Department of Microbiology, Faculty of Science 
      University of Yaounde I Yaounde Cameroon.
LA  - eng
PT  - Journal Article
DEP - 20220715
PL  - Australia
TA  - JGH Open
JT  - JGH open : an open access journal of gastroenterology and hepatology
JID - 101730833
PMC - PMC9344585
OTO - NOTNLM
OT  - Cameroon
OT  - Helicobacter pylori infection
OT  - anemia
OT  - iron deficiency
OT  - iron deficiency anemia
EDAT- 2022/08/06 06:00
MHDA- 2022/08/06 06:01
PMCR- 2022/07/15
CRDT- 2022/08/05 02:15
PHST- 2022/02/14 00:00 [received]
PHST- 2022/06/23 00:00 [revised]
PHST- 2022/06/26 00:00 [accepted]
PHST- 2022/08/05 02:15 [entrez]
PHST- 2022/08/06 06:00 [pubmed]
PHST- 2022/08/06 06:01 [medline]
PHST- 2022/07/15 00:00 [pmc-release]
AID - JGH312787 [pii]
AID - 10.1002/jgh3.12787 [doi]
PST - epublish
SO  - JGH Open. 2022 Jul 15;6(8):554-568. doi: 10.1002/jgh3.12787. eCollection 2022 
      Aug.