PMID- 35929252
OWN - NLM
STAT- MEDLINE
DCOM- 20220808
LR  - 20220808
IS  - 2772-9508 (Electronic)
IS  - 2772-9508 (Linking)
VI  - 137
DP  - 2022 Jun
TI  - Transition metal complex laminated bioactive implant alleviates Methicillin 
      Resistant Staphylococcus aureus virulence.
PG  - 212813
LID - S2772-9508(22)00090-5 [pii]
LID - 10.1016/j.bioadv.2022.212813 [doi]
AB  - Orthopedic implant infections cause a serious threat after implantation. The 
      major source of implant infection is biofilms which are highly tolerant to 
      antibiotics due to the presence of rigid biofilm matrix. Hence to overcome 
      biofilm mediated implant infections, we developed a novel antibiofilm agent, 
      palladium (II) thiazolinyl picolinamide complex (Pd(II)-E). From our study, it 
      was found that Pd(II)-E have profound biofilm inhibition activity and also 
      reduced various virulence factors of Methicillin resistant Staphylococcus aureus 
      (MRSA) including slime synthesis, Phenol soluble modulin (PSM) mediated 
      spreading, Exopolysaccharides production and staphyloxanthin synthesis. Further, 
      Pd(II)-E was coated over the titanium plates which was confirmed using EDX 
      (Energy Dispersive X-Ray) analysis. The Pd(II)-E coated plates were able to 
      prevent the biofilm formation on them which was evident under a Scanning electron 
      microscope (SEM) and several virulent genes were found to be downregulated in the 
      biofilms on the coated titanium plates which confirmed by qPCR. From our 
      findings, it was found that Pd(II)-E coated titanium implants would be an 
      effective alternate approach for preventing biofilm mediated implant infections.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Jothipandiyan, Sowndarya
AU  - Jothipandiyan S
AD  - Biofilm Biology Laboratory, Centre for Research on Infectious Diseases (CRID), 
      School of Chemical and Biotechnology, SASTRA Deemed University, 
      Tirumalaisamudram, Thanjavur 613 401, Tamil Nadu, India.
FAU - Suresh, Devarajan
AU  - Suresh D
AD  - Department of Chemistry, School of Chemical and Biotechnology, SASTRA Deemed 
      University, Thanjavur 613 401, Tamil Nadu, India.
FAU - Sekaran, Saravanan
AU  - Sekaran S
AD  - Department of Prosthodontics, Saveetha Dental College and Hospitals, Saveetha 
      Institute for Medical and Technical Sciences, Chennai 600077, Tamil Nadu, India.
FAU - Sudharsan, Murugesan
AU  - Sudharsan M
AD  - Department of Chemistry, School of Chemical and Biotechnology, SASTRA Deemed 
      University, Thanjavur 613 401, Tamil Nadu, India.
FAU - Subramanian, Raghunandhakumar
AU  - Subramanian R
AD  - Department of Prosthodontics, Saveetha Dental College and Hospitals, Saveetha 
      Institute for Medical and Technical Sciences, Chennai 600077, Tamil Nadu, India.
FAU - Paramasivam, Nithyanand
AU  - Paramasivam N
AD  - Biofilm Biology Laboratory, Centre for Research on Infectious Diseases (CRID), 
      School of Chemical and Biotechnology, SASTRA Deemed University, 
      Tirumalaisamudram, Thanjavur 613 401, Tamil Nadu, India. Electronic address: 
      pnithyanand@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20220420
PL  - Netherlands
TA  - Biomater Adv
JT  - Biomaterials advances
JID - 9918383886206676
RN  - D1JT611TNE (Titanium)
SB  - IM
MH  - Biofilms
MH  - Humans
MH  - *Methicillin-Resistant Staphylococcus aureus
MH  - *Staphylococcal Infections/drug therapy
MH  - Titanium/pharmacology
MH  - Virulence
OTO - NOTNLM
OT  - Biofilms
OT  - Coating
OT  - Implant infection
OT  - MRSA
OT  - Metal complex
OT  - Virulence
EDAT- 2022/08/06 06:00
MHDA- 2022/08/09 06:00
CRDT- 2022/08/05 03:44
PHST- 2022/01/05 00:00 [received]
PHST- 2022/03/30 00:00 [revised]
PHST- 2022/04/15 00:00 [accepted]
PHST- 2022/08/05 03:44 [entrez]
PHST- 2022/08/06 06:00 [pubmed]
PHST- 2022/08/09 06:00 [medline]
AID - S2772-9508(22)00090-5 [pii]
AID - 10.1016/j.bioadv.2022.212813 [doi]
PST - ppublish
SO  - Biomater Adv. 2022 Jun;137:212813. doi: 10.1016/j.bioadv.2022.212813. Epub 2022 
      Apr 20.