PMID- 35929262
OWN - NLM
STAT- MEDLINE
DCOM- 20220808
LR  - 20220808
IS  - 2772-9508 (Electronic)
IS  - 2772-9508 (Linking)
VI  - 137
DP  - 2022 Jun
TI  - A biomechanical evaluation on Cubic, Octet, and TPMS gyroid Ti6Al4V lattice 
      structures fabricated by selective laser melting and the effects of their debris 
      on human osteoblast-like cells.
PG  - 212829
LID - S2772-9508(22)00106-6 [pii]
LID - 10.1016/j.bioadv.2022.212829 [doi]
AB  - Lattice structures are widely used in orthopedic implants due to their unique 
      features, such as high strength-to-weight ratios and adjustable biomechanical 
      properties. Based on the type of unit cell geometry, lattice structures may be 
      classified into two types: strut-based structures and sheet-based structures. In 
      this study, strut-based structures (Cubic & Octet) and sheet-based structure 
      (triply periodic minimal surface (TPMS) gyroid) were investigated. The 
      biomechanical properties of the three different Ti6Al4V lattice structures 
      fabricated by selective laser melting (SLM) were investigated using room 
      temperature compression testing. Scanning electron microscopy (SEM) and energy 
      dispersive X-ray spectroscopy (EDX) were used to check the 3D printing quality 
      with regards to defects and quantitative compositional information of 3D printed 
      parts. Experimental results indicated that TPMS gyroid has superior biomechanical 
      properties when compared to Cubic and Octet. Also, TPMS gyroid was found to be 
      less affected by the variations in relative density. The biocompatibility of 
      Ti6Al4V lattice structures was validated through the cytotoxicity test with human 
      osteoblast-like SAOS2 cells. The debris generated during the degradation process 
      in the form of particles and ions is among the primary causes of implant failure 
      over time. In this study, Ti6Al4V particles with spherical and irregular shapes 
      having average particle sizes of 36.5 mum and 28.8 mum, respectively, were used to 
      mimic the actual Ti6Al4V particles to understand their harmful effects better. 
      Also, the effects and amount of Ti6Al4V ions released after immersion within the 
      cell culture media were investigated using the indirect cytotoxicity test and ion 
      release test.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Wang, Niyou
AU  - Wang N
AD  - Department of Mechanical Engineering, 9 Engineering Drive 1, #07-08 Block EA, 
      National University of Singapore, 117575, Singapore.
FAU - Meenashisundaram, Ganesh Kumar
AU  - Meenashisundaram GK
AD  - Singapore Institute of Manufacturing and Technology, 73 Nanyang Drive, 637662, 
      Singapore.
FAU - Kandilya, Deepika
AU  - Kandilya D
AD  - Department of Anatomy, 4 Medical Drive, MD10, Yong Loo Lin School of Medicine, 
      National University of Singapore, 117594, Singapore.
FAU - Fuh, Jerry Ying Hsi
AU  - Fuh JYH
AD  - Department of Mechanical Engineering, 9 Engineering Drive 1, #07-08 Block EA, 
      National University of Singapore, 117575, Singapore.
FAU - Dheen, S Thameem
AU  - Dheen ST
AD  - Department of Anatomy, 4 Medical Drive, MD10, Yong Loo Lin School of Medicine, 
      National University of Singapore, 117594, Singapore.
FAU - Kumar, A Senthil
AU  - Kumar AS
AD  - Department of Mechanical Engineering, 9 Engineering Drive 1, #07-08 Block EA, 
      National University of Singapore, 117575, Singapore. Electronic address: 
      asenthil@nus.edu.sg.
LA  - eng
PT  - Journal Article
DEP - 20220428
PL  - Netherlands
TA  - Biomater Adv
JT  - Biomaterials advances
JID - 9918383886206676
RN  - 0 (Alloys)
RN  - 12743-70-3 (titanium alloy (TiAl6V4))
RN  - D1JT611TNE (Titanium)
SB  - IM
MH  - Alloys
MH  - Humans
MH  - *Lasers
MH  - Materials Testing
MH  - *Osteoblasts
MH  - Porosity
MH  - Titanium
OTO - NOTNLM
OT  - Biomechanical property
OT  - Cytotoxicity
OT  - Debris
OT  - Lattice structures
OT  - SLM
OT  - Ti6Al4V
EDAT- 2022/08/06 06:00
MHDA- 2022/08/09 06:00
CRDT- 2022/08/05 03:44
PHST- 2022/03/23 00:00 [received]
PHST- 2022/04/20 00:00 [revised]
PHST- 2022/04/23 00:00 [accepted]
PHST- 2022/08/05 03:44 [entrez]
PHST- 2022/08/06 06:00 [pubmed]
PHST- 2022/08/09 06:00 [medline]
AID - S2772-9508(22)00106-6 [pii]
AID - 10.1016/j.bioadv.2022.212829 [doi]
PST - ppublish
SO  - Biomater Adv. 2022 Jun;137:212829. doi: 10.1016/j.bioadv.2022.212829. Epub 2022 
      Apr 28.