PMID- 35931625 OWN - NLM STAT- MEDLINE DCOM- 20221101 LR - 20221228 IS - 1878-3562 (Electronic) IS - 1590-8658 (Linking) VI - 54 IP - 11 DP - 2022 Nov TI - Double guide-wire technique versus transpancreatic biliary sphincterotomy for difficult biliary cannulation: Real life experience from a referral center. PG - 1548-1553 LID - S1590-8658(22)00594-1 [pii] LID - 10.1016/j.dld.2022.07.011 [doi] AB - BACKGROUND: During ERCP for biliary indication, when a difficult bile duct (BD) cannulation occurs, with unintended access to the main pancreatic duct (PD), both double guidewire technique (DGW) and transpancreatic biliary sphincterotomy (TPBS) can be performed. We aimed to compare the technical success and adverse events (AEs) rate of these techniques. METHODS: A retrospective analysis of patients with naive papillae referred to the Pancreas Institute of Verona from January 2016 and July 2021 to undergo ERCP for biliary indications was performed. RESULTS: Overall, 202 patients (53.5% males, mean age 67.2 years) were evaluated (96 DGW, 106 TPBS). Malignant biliary stricture was the most common ERCP indication (78.2%). The rate of success in deep biliary cannulation was significantly higher in the DGW group (94.8%) compared to TPBS (79.2%) at the first attempt (p = 0.001). This result was also confirmed in the subgroup of patients with malignant distal stricture (72/77, 93.5% vs 63/80, 78.8%, p = 0.01). No significant difference in AEs rate, particularly in PEP incidence was found between the two groups. CONCLUSIONS: DGW demonstrated a higher success rate and similar safety profile compared with TPBS in difficult biliary cannulation. Based on this retrospective study, DGW should be preferred over TPBS in case of unintended PD cannulation. Further prospective studies are needed to confirm our results. CI - Copyright (c) 2022 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved. FAU - Pin, Federico AU - Pin F AD - Diagnostic and interventional Endoscopy of Pancreas, Pancreas Institute, University of Verona, Italy. FAU - Conti Bellocchi, Maria Cristina AU - Conti Bellocchi MC AD - Diagnostic and interventional Endoscopy of Pancreas, Pancreas Institute, University of Verona, Italy. Electronic address: mariacristina.contibellocchi@aovr.veneto.it. FAU - Crino, Stefano Francesco AU - Crino SF AD - Diagnostic and interventional Endoscopy of Pancreas, Pancreas Institute, University of Verona, Italy. FAU - Bernardoni, Laura AU - Bernardoni L AD - Diagnostic and interventional Endoscopy of Pancreas, Pancreas Institute, University of Verona, Italy. FAU - Facciorusso, Antonio AU - Facciorusso A AD - Digestive Endoscopy Unit, Department of Medical Sciences, University of Foggia, Foggia, Italy. FAU - Gabbrielli, Armando AU - Gabbrielli A AD - Diagnostic and interventional Endoscopy of Pancreas, Pancreas Institute, University of Verona, Italy. LA - eng PT - Comment PT - Journal Article DEP - 20220802 PL - Netherlands TA - Dig Liver Dis JT - Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver JID - 100958385 SB - IM CON - Endoscopy. 2021 Oct;53(10):1011-1019. PMID: 33440441 MH - Male MH - Humans MH - Aged MH - Female MH - *Sphincterotomy, Endoscopic/adverse effects/methods MH - Retrospective Studies MH - Constriction, Pathologic/etiology MH - Treatment Outcome MH - *Catheterization/methods MH - Cholangiopancreatography, Endoscopic Retrograde/adverse effects/methods MH - Referral and Consultation OTO - NOTNLM OT - Difficult biliary cannulation OT - Distal stricture OT - Double-guidewire technique OT - Endoscopic retrograde cholangiopancreatography OT - Transpancreatic biliary sphincterotomy OT - post-ERCP pancreatitis EDAT- 2022/08/06 06:00 MHDA- 2022/11/02 06:00 CRDT- 2022/08/05 22:06 PHST- 2022/05/20 00:00 [received] PHST- 2022/07/19 00:00 [accepted] PHST- 2022/08/06 06:00 [pubmed] PHST- 2022/11/02 06:00 [medline] PHST- 2022/08/05 22:06 [entrez] AID - S1590-8658(22)00594-1 [pii] AID - 10.1016/j.dld.2022.07.011 [doi] PST - ppublish SO - Dig Liver Dis. 2022 Nov;54(11):1548-1553. doi: 10.1016/j.dld.2022.07.011. Epub 2022 Aug 2.