PMID- 35932762
OWN - NLM
STAT- MEDLINE
DCOM- 20220819
LR  - 20220908
IS  - 2666-3791 (Electronic)
IS  - 2666-3791 (Linking)
VI  - 3
IP  - 8
DP  - 2022 Aug 16
TI  - Heritable vaginal bacteria influence immune tolerance and relate to early-life 
      markers of allergic sensitization in infancy.
PG  - 100713
LID - S2666-3791(22)00256-7 [pii]
LID - 10.1016/j.xcrm.2022.100713 [doi]
LID - 100713
AB  - Maternal asthma status, prenatal exposures, and infant gut microbiota 
      perturbation are associated with heightened risk of atopy and asthma risk in 
      childhood, observations hypothetically linked by intergenerational microbial 
      transmission. Using maternal vaginal (n = 184) and paired infant stool (n = 172) 
      samples, we identify four compositionally and functionally distinct 
      Lactobacillus-dominated vaginal microbiota clusters (VCs) that relate to prenatal 
      maternal health and exposures and infant serum immunoglobulin E (IgE) status at 1 
      year. Variance in bacteria shared between mother and infant pairs relate to VCs, 
      maternal allergy/asthma status, and infant IgE levels. Heritable bacterial gene 
      pathways associated with infant IgE include fatty acid synthesis and histamine 
      and tryptophan degradation. In vitro, vertically transmitted Lactobacillus 
      jensenii strains induce immunosuppressive phenotypes on human antigen-presenting 
      cells. Murine supplementation with L. jensenii reduces lung eosinophils, 
      neutrophilic expansion, and the proportion of interleukin-4 (IL-4)(+) CD4(+) 
      T cells. Thus, bacterial and atopy heritability are intimately linked, suggesting 
      a microbial component of intergenerational disease transmission.
CI  - Copyright (c) 2022 The Author(s). Published by Elsevier Inc. All rights reserved.
FAU - McCauley, Kathryn E
AU  - McCauley KE
AD  - Department of Medicine, University of California, San Francisco, San Francisco, 
      CA 94143, USA.
FAU - Rackaityte, Elze
AU  - Rackaityte E
AD  - Department of Biochemistry and Biophysics, University of California, San 
      Francisco, San Francisco, CA 94143, USA.
FAU - LaMere, Brandon
AU  - LaMere B
AD  - Department of Medicine, University of California, San Francisco, San Francisco, 
      CA 94143, USA.
FAU - Fadrosh, Douglas W
AU  - Fadrosh DW
AD  - Department of Medicine, University of California, San Francisco, San Francisco, 
      CA 94143, USA.
FAU - Fujimura, Kei E
AU  - Fujimura KE
AD  - Department of Medicine, University of California, San Francisco, San Francisco, 
      CA 94143, USA.
FAU - Panzer, Ariane R
AU  - Panzer AR
AD  - Department of Medicine, University of California, San Francisco, San Francisco, 
      CA 94143, USA.
FAU - Lin, Din L
AU  - Lin DL
AD  - Department of Medicine, University of California, San Francisco, San Francisco, 
      CA 94143, USA.
FAU - Lynch, Kole V
AU  - Lynch KV
AD  - Department of Medicine, University of California, San Francisco, San Francisco, 
      CA 94143, USA.
FAU - Halkias, Joanna
AU  - Halkias J
AD  - Department of Pediatrics, University of California, San Francisco, San Francisco, 
      CA 94143, USA.
FAU - Mendoza, Ventura F
AU  - Mendoza VF
AD  - Department of Pediatrics, University of California, San Francisco, San Francisco, 
      CA 94143, USA; Department of Process Development, PACT Pharma, South San 
      Francisco, CA, USA.
FAU - Burt, Trevor D
AU  - Burt TD
AD  - Division of Neonatology and the Children's Health and Discovery Initiative, 
      Department of Pediatrics, Duke University, Durham, NC 27705, USA.
FAU - Bendixsen, Casper
AU  - Bendixsen C
AD  - Marshfield Clinic Research Institute, Marshfield, WI 54449, USA.
FAU - Barnes, Kathrine
AU  - Barnes K
AD  - Marshfield Clinic Research Institute, Marshfield, WI 54449, USA.
FAU - Kim, Haejin
AU  - Kim H
AD  - Henry Ford Health System, Detroit, MI 48202, USA.
FAU - Jones, Kyra
AU  - Jones K
AD  - Henry Ford Health System, Detroit, MI 48202, USA.
FAU - Ownby, Dennis R
AU  - Ownby DR
AD  - Henry Ford Health System, Detroit, MI 48202, USA.
FAU - Johnson, Christine C
AU  - Johnson CC
AD  - Henry Ford Health System, Detroit, MI 48202, USA.
FAU - Seroogy, Christine M
AU  - Seroogy CM
AD  - University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, 
      USA.
FAU - Gern, James E
AU  - Gern JE
AD  - University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, 
      USA.
FAU - Boushey, Homer A
AU  - Boushey HA
AD  - Department of Medicine, University of California, San Francisco, San Francisco, 
      CA 94143, USA.
FAU - Lynch, Susan V
AU  - Lynch SV
AD  - Department of Medicine, University of California, San Francisco, San Francisco, 
      CA 94143, USA. Electronic address: susan.lynch@ucsf.edu.
CN  - ECHO Children's Respiratory and Environmental Workgroup
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20220806
PL  - United States
TA  - Cell Rep Med
JT  - Cell reports. Medicine
JID - 101766894
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Animals
MH  - *Asthma/genetics
MH  - Bacteria/genetics
MH  - Female
MH  - *Gastrointestinal Microbiome/genetics
MH  - Humans
MH  - *Hypersensitivity, Immediate
MH  - Immune Tolerance/genetics
MH  - Immunoglobulin E
MH  - Infant
MH  - Mice
MH  - Pregnancy
PMC - PMC9418802
OTO - NOTNLM
OT  - Lactobacillus
OT  - asthma
OT  - atopy
OT  - immune tolerance
OT  - inherited bacteria
OT  - microbiota
OT  - prenatal
OT  - transmission
OT  - vaginal
OT  - vaginal microbiota
COIS- Declaration of interests J.E.G. is a paid consultant for AstraZeneca, Meissa 
      Vaccines Inc., and Gossamer Bio and has stock options in Meissa Vaccines Inc. 
      H.A.B. serves on a scientific advisory committee for Siolta Therapeutics Inc. 
      S.V.L. is a co-founder and member of the board and consults for and holds stock 
      options in Siolta Therapeutics Inc.; she also consults for Solarea Bio. The 
      Regents of UCSF have filed a patent application (PCT/US2019/045,354) on behalf of 
      S.V.L. and E.R. relating to the methods and compositions of fetal bacteria.
EDAT- 2022/08/07 06:00
MHDA- 2022/08/20 06:00
PMCR- 2022/08/06
CRDT- 2022/08/06 18:42
PHST- 2021/08/21 00:00 [received]
PHST- 2022/04/27 00:00 [revised]
PHST- 2022/07/13 00:00 [accepted]
PHST- 2022/08/07 06:00 [pubmed]
PHST- 2022/08/20 06:00 [medline]
PHST- 2022/08/06 18:42 [entrez]
PHST- 2022/08/06 00:00 [pmc-release]
AID - S2666-3791(22)00256-7 [pii]
AID - 100713 [pii]
AID - 10.1016/j.xcrm.2022.100713 [doi]
PST - ppublish
SO  - Cell Rep Med. 2022 Aug 16;3(8):100713. doi: 10.1016/j.xcrm.2022.100713. Epub 2022 
      Aug 6.