PMID- 35933436
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220810
IS  - 1710-1484 (Print)
IS  - 1710-1492 (Electronic)
IS  - 1710-1484 (Linking)
VI  - 18
IP  - 1
DP  - 2022 Aug 6
TI  - Drug-induced hypersensitivity syndrome induced by propylthiouracil: case report 
      and literature review.
PG  - 69
LID - 10.1186/s13223-022-00707-w [doi]
LID - 69
AB  - BACKGROUND: Drug-induced hypersensitivity syndrome (DIHS) is a rare, potentially 
      life-threatening systemic drug reaction. Antithyroid drugs (ATDs) causing DIHS 
      have seldom been reported before. CASE PRESENTATION: We present a case of 
      propylthiouracil (PTU)-induced DIHS, which included fever, skin rash, 
      lymphadenopathy, hepatosplenomegaly, serious liver and kidney dysfunction, 
      peripheral blood eosinophilia, and atypical lymphocytosis. Following supportive 
      therapy, intravenous immunoglobulin (IVIG), and systemic corticosteroid, the 
      patient experienced a resolution of fever and rash combined with progressive 
      normalization of hematological index and organ function. These clinical features, 
      and the skin lesion biopsy confirmed DIHS diagnosis. CONCLUSIONS: To our 
      knowledge, this is the second reported case of PTU-induced DIHS worldwide and the 
      first human leukocyte antigen (HLA) typing of PTU-induced DIHS. Clinicians should 
      cautiously distinguish hyperthyroidism etiology and identify the indication of 
      ATDs. Timely recognition and formal DIHS treatment are required in patients with 
      ATDs.
CI  - (c) 2022. The Author(s).
FAU - Wu, Fang
AU  - Wu F
AD  - Department of Endocrinology, Zhejiang University School of Medicine Sir Run Run 
      Shaw Hospital, Hangzhou, Zhejiang, China.
FAU - Jin, Ting
AU  - Jin T
AD  - Department of Endocrinology, Zhejiang University School of Medicine Sir Run Run 
      Shaw Hospital, Hangzhou, Zhejiang, China.
FAU - Shang, Chengxin
AU  - Shang C
AD  - Department of Endocrinology, Zhejiang University School of Medicine Sir Run Run 
      Shaw Hospital, Hangzhou, Zhejiang, China.
FAU - Lin, Xihua
AU  - Lin X
AD  - Department of Endocrinology, Zhejiang University School of Medicine Sir Run Run 
      Shaw Hospital, Hangzhou, Zhejiang, China.
AD  - Biomedical Research Center and Key Laboratory of Biotherapy of Zhejiang Province, 
      Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 
      Zhejiang, China.
FAU - Gong, Xiaoqin
AU  - Gong X
AD  - Department of Gynecology, Pujiang People Hospital, Pujiang Country, Zhejiang, 
      China.
FAU - Wang, Zhou
AU  - Wang Z
AUID- ORCID: 0000-0002-8688-0445
AD  - Department of Endocrinology, Zhejiang University School of Medicine Sir Run Run 
      Shaw Hospital, Hangzhou, Zhejiang, China. 3405008@zju.edu.cn.
LA  - eng
GR  - 30800533/National Natural Science Foundation of China for Youth/
GR  - 2012C33131/Science and Technology Project of Zhejiang Province/
GR  - 2015RCA013/Zhejiang Provincial Key Laboratory of Wood Science and Technology/
PT  - Journal Article
DEP - 20220806
PL  - England
TA  - Allergy Asthma Clin Immunol
JT  - Allergy, asthma, and clinical immunology : official journal of the Canadian 
      Society of Allergy and Clinical Immunology
JID - 101244313
PMC - PMC9357314
OTO - NOTNLM
OT  - Drug-induced hypersensitivity syndrome
OT  - Human leukocyte antigen
OT  - Propylthiouracil
COIS- The authors declare no competing interests.
EDAT- 2022/08/07 06:00
MHDA- 2022/08/07 06:01
PMCR- 2022/08/06
CRDT- 2022/08/06 23:22
PHST- 2021/12/14 00:00 [received]
PHST- 2022/07/05 00:00 [accepted]
PHST- 2022/08/06 23:22 [entrez]
PHST- 2022/08/07 06:00 [pubmed]
PHST- 2022/08/07 06:01 [medline]
PHST- 2022/08/06 00:00 [pmc-release]
AID - 10.1186/s13223-022-00707-w [pii]
AID - 707 [pii]
AID - 10.1186/s13223-022-00707-w [doi]
PST - epublish
SO  - Allergy Asthma Clin Immunol. 2022 Aug 6;18(1):69. doi: 
      10.1186/s13223-022-00707-w.