PMID- 35933599
OWN - NLM
STAT- MEDLINE
DCOM- 20221214
LR  - 20221226
IS  - 1399-0012 (Electronic)
IS  - 0902-0063 (Linking)
VI  - 36
IP  - 11
DP  - 2022 Nov
TI  - Evaluation of the Iranian panel reactive antibody calculator and potential 
      usefulness: A retrospective study.
PG  - e14789
LID - 10.1111/ctr.14789 [doi]
AB  - BACKGROUND AND OBJECTIVES: There are several cPRA websites based on large enough 
      samples in Eurotransplant, the United Network for Organ Sharing (UNOS), and the 
      Canadian Transplant Registry (CTR). On the other hand, those calculators can 
      differ based on the ethnicity to which they are applied. We developed the Iranian 
      PRA calculator and compared it with UNOS and CTR calculators. METHODS: The allele 
      and haplotype frequencies of the Iranian donor pool were estimated using the HLA 
      typing of 523 deceased Iranian kidney donors. The Organ Procurement and 
      Transplantation Network formula was used to generate cPRA (cPRA frequency). We 
      also used a computer script to compare the undesirable antigens of patients with 
      the human leukocyte antigen (HLA) phenotype of donors (cPRA filtering). A total 
      of 100 anti-HLA antibody profiles were determined in 100 sensitized individuals 
      on the waiting list, and cPRA was estimated using various PRA calculators. 
      RESULTS: Variable allelic frequencies were obtained from population heterogeneity 
      in each calculator's donor panel. However, no significant changes in cPRA were 
      identified between the Iranian calculator, UNOS, and the Canadian online 
      calculators. Lin's concordance correlation coefficient of .98 showed that cPRA 
      (freq) and cPRA (filter) values had almost perfect agreement. INTERPRETATION AND 
      CONCLUSION: The cPRA values from the Iranian calculator are comparable to those 
      from UNOS and CTR calculators. The donor filtering method was more useful because 
      of factors like cost and flexibility. It also makes it easier to update cPRA on a 
      regular basis.
CI  - (c) 2022 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Mohammadzadeh, Sahand
AU  - Mohammadzadeh S
AD  - Shiraz Transplant Center, Abu-Ali Sina Hospital, Shiraz University of Medical 
      Sciences, Shiraz, Iran.
FAU - Jaladat, Abdul Reza
AU  - Jaladat AR
AD  - Shiraz Transplant Center, Abu-Ali Sina Hospital, Shiraz University of Medical 
      Sciences, Shiraz, Iran.
FAU - Mohammadi, Maryam
AU  - Mohammadi M
AD  - Faculty of Electrical and Computer Engineering, Shiraz University, Shiraz, Iran.
FAU - Geramizadeh, Bita
AU  - Geramizadeh B
AD  - Shiraz Transplant Center, Abu-Ali Sina Hospital, Shiraz University of Medical 
      Sciences, Shiraz, Iran.
FAU - Anbardar, Mohammad Hossein
AU  - Anbardar MH
AUID- ORCID: 0000-0002-2317-0737
AD  - Shiraz Transplant Center, Abu-Ali Sina Hospital, Shiraz University of Medical 
      Sciences, Shiraz, Iran.
FAU - Soleimani, Neda
AU  - Soleimani N
AD  - Shiraz Transplant Center, Abu-Ali Sina Hospital, Shiraz University of Medical 
      Sciences, Shiraz, Iran.
FAU - Amirinezhad Fard, Elahe
AU  - Amirinezhad Fard E
AD  - Medical Biology Research Center, Kermanshah University of Medical Sciences, 
      Kermanshah, Iran.
FAU - Tehrani, Narges Jamshidian
AU  - Tehrani NJ
AD  - Shiraz Transplant Center, Abu-Ali Sina Hospital, Shiraz University of Medical 
      Sciences, Shiraz, Iran.
LA  - eng
PT  - Journal Article
DEP - 20220819
PL  - Denmark
TA  - Clin Transplant
JT  - Clinical transplantation
JID - 8710240
RN  - 0 (Isoantibodies)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Humans
MH  - Isoantibodies
MH  - Retrospective Studies
MH  - Iran
MH  - *Kidney Transplantation/methods
MH  - Canada
MH  - Histocompatibility Testing/methods
MH  - HLA Antigens/genetics
MH  - Tissue Donors
MH  - *Tissue and Organ Procurement
OTO - NOTNLM
OT  - calculated panel reactive antibody
OT  - organ allocation
OT  - renal transplantation
OT  - sensitization
OT  - unacceptable antigen
OT  - virtual crossmatch
EDAT- 2022/08/08 06:00
MHDA- 2022/12/15 06:00
CRDT- 2022/08/07 04:12
PHST- 2022/06/08 00:00 [revised]
PHST- 2021/11/22 00:00 [received]
PHST- 2022/07/29 00:00 [accepted]
PHST- 2022/08/08 06:00 [pubmed]
PHST- 2022/12/15 06:00 [medline]
PHST- 2022/08/07 04:12 [entrez]
AID - 10.1111/ctr.14789 [doi]
PST - ppublish
SO  - Clin Transplant. 2022 Nov;36(11):e14789. doi: 10.1111/ctr.14789. Epub 2022 Aug 
      19.