PMID- 35934145 OWN - NLM STAT- MEDLINE DCOM- 20220914 LR - 20220929 IS - 1096-0953 (Electronic) IS - 0013-9351 (Linking) VI - 214 IP - Pt 3 DP - 2022 Nov TI - Individual and joint associations of co-exposure to multiple plasma metals with telomere length among middle-aged and older Chinese in the Dongfeng-Tongji cohort. PG - 114031 LID - S0013-9351(22)01358-5 [pii] LID - 10.1016/j.envres.2022.114031 [doi] AB - Studies on associations of metals with leucocyte telomere length (LTL) were mainly limited to several most common toxic metals and single-metal effect, but the impact of other common metals and especially the overall joint associations and interactions of metal mixture with LTL are largely unknown. We included 15 plasma metals and LTL among 4906 participants from Dongfeng-Tongji cohort. Multivariable linear regression was used to estimate associations of individual metals with LTL. We also applied Bayesian kernel machine regression (BKMR) and quantile g-computation regression (Q-g) to evaluate the overall association and interactions, and identified the major contributors as well as the potential modifications by major characteristics. Multivariable linear regression found vanadium, copper, arsenic, aluminum and nickel were negatively associated with LTL, and a 2-fold change was related to 1.9%-5.1% shorter LTL; while manganese and zinc showed 3.7% and 4.0% longer LTL (all P < 0.05) in multiple-metal models. BKMR confirmed above metals and revealed a linearly inverse joint association between 15 metals and LTL. Q-g regression further indicated each quantile increase in mixture was associated with 5.2% shorter LTL (95% CI: -8.1%, -2.3%). Furthermore, manganese counteracted against aluminum and vanadium respectively (P(int)<0.05). In addition, associations of vanadium, aluminum and metal mixture with LTL were more prominent in overweight participants. Our results are among the first to provide a new comprehensive view of metal mixture exposure on LTL attrition in the general population, including identifying the major components, metals interactions and the overall effects. CI - Copyright (c) 2022 Elsevier Inc. All rights reserved. FAU - Lai, Xuefeng AU - Lai X AD - Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, And State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China. Electronic address: xuefeng_lai416@163.com. FAU - Yuan, Yu AU - Yuan Y AD - Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, And State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China. FAU - Liu, Miao AU - Liu M AD - Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, And State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China. FAU - Xiao, Yang AU - Xiao Y AD - Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, And State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China. FAU - Ma, Lin AU - Ma L AD - Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, And State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China. FAU - Guo, Wenting AU - Guo W AD - Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, And State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China. FAU - Fang, Qin AU - Fang Q AD - Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, And State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China. FAU - Yang, Huihua AU - Yang H AD - Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, And State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China. FAU - Hou, Jian AU - Hou J AD - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, 450001, Henan, China. FAU - Yang, Liangle AU - Yang L AD - Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, And State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China. FAU - Yang, Handong AU - Yang H AD - Department of Cardiovascular Diseases, Sinopharm Dongfeng General Hospital, Hubei University of Medicine, Shiyan, 442000, Hubei, China. FAU - He, Mei-An AU - He MA AD - Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, And State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China. FAU - Guo, Huan AU - Guo H AD - Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, And State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China. FAU - Zhang, Xiaomin AU - Zhang X AD - Department of Occupational and Environmental Health, Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, And State Key Laboratory of Environmental Health (Incubating), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, Hubei, China. Electronic address: mingxz117@163.com. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20220804 PL - Netherlands TA - Environ Res JT - Environmental research JID - 0147621 RN - 00J9J9XKDE (Vanadium) RN - 42Z2K6ZL8P (Manganese) RN - CPD4NFA903 (Aluminum) SB - IM MH - Aged MH - *Aluminum MH - Bayes Theorem MH - China MH - Humans MH - *Manganese MH - Middle Aged MH - Telomere MH - Vanadium/toxicity OTO - NOTNLM OT - Bayesian kernel machine regression OT - Joint association OT - Metal interaction OT - Metal mixture OT - Quantile g-computation regression OT - Telomere length COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2022/08/08 06:00 MHDA- 2022/09/15 06:00 CRDT- 2022/08/07 19:34 PHST- 2022/04/20 00:00 [received] PHST- 2022/07/29 00:00 [revised] PHST- 2022/07/31 00:00 [accepted] PHST- 2022/08/08 06:00 [pubmed] PHST- 2022/09/15 06:00 [medline] PHST- 2022/08/07 19:34 [entrez] AID - S0013-9351(22)01358-5 [pii] AID - 10.1016/j.envres.2022.114031 [doi] PST - ppublish SO - Environ Res. 2022 Nov;214(Pt 3):114031. doi: 10.1016/j.envres.2022.114031. Epub 2022 Aug 4.