PMID- 35934274
OWN - NLM
STAT- MEDLINE
DCOM- 20221004
LR  - 20221104
IS  - 1872-9738 (Electronic)
IS  - 0892-0362 (Linking)
VI  - 93
DP  - 2022 Sep-Oct
TI  - Effects of decabromodiphenyl ether (BDE-209) on ultrasonic vocalizations emitted 
      by rat pups during isolation.
PG  - 107118
LID - S0892-0362(22)00056-3 [pii]
LID - 10.1016/j.ntt.2022.107118 [doi]
AB  - Polybrominated diphenyl ethers (PBDEs) have been worldwide used as flame 
      retardants. Among them, decabromodiphenyl ether (BDE-209) is the most applied and 
      becomes ubiquitous in the environment and organisms. It can alter spontaneous 
      behavior and affect the cholinergic system in rodents. Ultrasonic vocalizations 
      (USVs) emitted by rat pups during isolation are widely employed as 
      neurobehavioral indexes, and the cholinergic system supports their normal 
      expression. However, whether BDE-209 can alter isolation USVs were unknown. In 
      this study, BDE-209 was daily administered to mothers at 0, 500, or 1000 mg/kg 
      b.w. from gestational day (GD) 15 to postnatal day (PND) 21. On PNDs 7, 10, 13, 
      and 16, rat pups were individually isolated from mothers, and their USVs were 
      recorded for 5 min after 5-min habituation and then analyzed. The results 
      indicated that BDE-209 exposure can cause acoustic alterations in isolation USVs. 
      The high-dose pups emitted USVs with shorter duration than the control pups did. 
      Moreover, the percentages of frequency-modulated (FM) USVs in the high-dose pups 
      were lower than those in the control pups. The mechanisms to alter acoustic 
      characteristics of isolation USVs need further investigation. USV analysis is a 
      useful method that provides neurobehavioral evidence.
CI  - Copyright (c) 2022 Elsevier Inc. All rights reserved.
FAU - Qi, Yiming
AU  - Qi Y
AD  - Division of Psychology, Graduate School of Humanities and Human Sciences, 
      Hokkaido University, Kita 10 Nishi 7 Kita-Ku, Sapporo 060-0810, Japan. Electronic 
      address: qiyiming@eis.hokudai.ac.jp.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220805
PL  - United States
TA  - Neurotoxicol Teratol
JT  - Neurotoxicology and teratology
JID - 8709538
RN  - 0 (Cholinergic Agents)
RN  - 0 (Flame Retardants)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - N80BQ29A0H (decabromobiphenyl ether)
SB  - IM
MH  - Animals
MH  - Cholinergic Agents/pharmacology
MH  - *Flame Retardants/toxicity
MH  - *Halogenated Diphenyl Ethers/toxicity
MH  - Rats
MH  - Ultrasonics
MH  - Vocalization, Animal
OTO - NOTNLM
OT  - BDE-209
OT  - Isolation
OT  - Rat pups
OT  - Ultrasonic vocalizations (USVs)
COIS- Declaration of Competing Interest None.
EDAT- 2022/08/08 06:00
MHDA- 2022/10/05 06:00
CRDT- 2022/08/07 19:37
PHST- 2022/02/22 00:00 [received]
PHST- 2022/07/18 00:00 [revised]
PHST- 2022/08/01 00:00 [accepted]
PHST- 2022/08/08 06:00 [pubmed]
PHST- 2022/10/05 06:00 [medline]
PHST- 2022/08/07 19:37 [entrez]
AID - S0892-0362(22)00056-3 [pii]
AID - 10.1016/j.ntt.2022.107118 [doi]
PST - ppublish
SO  - Neurotoxicol Teratol. 2022 Sep-Oct;93:107118. doi: 10.1016/j.ntt.2022.107118. 
      Epub 2022 Aug 5.