PMID- 35934808
OWN - NLM
STAT- MEDLINE
DCOM- 20230515
LR  - 20230526
IS  - 1468-1293 (Electronic)
IS  - 1464-2662 (Linking)
VI  - 24
IP  - 5
DP  - 2023 May
TI  - A matched cohort study investigating premature, accentuated, and accelerated 
      aging in people living with HIV.
PG  - 640-647
LID - 10.1111/hiv.13375 [doi]
AB  - INTRODUCTION: The impact of HIV infection on the aging process is disputed and 
      largely unknown. We aimed to identify whether people living with HIV experience 
      premature, accelerated, and/or accentuated aging by investigating the development 
      of four age-related non-communicable diseases in people living with versus 
      without HIV. METHODS: This population-based matched cohort study design used 
      UK-based primary care electronic health records from the IQVIA Medical Research 
      Database. Between January 2000 and January 2020, all people living with and 
      without HIV aged >/=18 years were eligible. Outcomes included cardiovascular 
      disease (CVD), hypertension, type 2 diabetes mellitus (T2DM), and chronic kidney 
      disease (CKD), which were identified by Read codes. We used age at diagnosis to 
      investigate premature aging and age at exit date to investigate accentuation and 
      acceleration. For each outcome, people with and without HIV were excluded if they 
      had the outcome of interest at baseline. Participants were matched based on 
      propensity scores (1:1 ratio). Linear regression was used to report any 
      difference in age at diagnosis between the two groups and to report the 
      prevalence trends for age at exit date. RESULTS: In total, 8880 people living 
      with HIV were matched with 8880 people without HIV and were found to have an 
      earlier onset of CVD (54.5 vs. 56.8; p = 0.002). Similarly, people living with 
      HIV had an earlier onset of hypertension (49.7 vs. 51.4; p = 0.002). No 
      difference was found for T2DM or CKD (53.4 vs. 52.6; p = 0.368 and 57.6 vs. 58.1; 
      p = 0.483, respectively). The burden of CKD increased over time, whereas no 
      difference in the burden was found for the other conditions. CONCLUSION: The 
      earlier development of CVD and hypertension in people living with HIV than in 
      those without HIV indicates premature aging, whereas the increased burden of CKD 
      indicates accelerated aging.
CI  - (c) 2022 The Authors. HIV Medicine published by John Wiley & Sons Ltd on behalf of 
      British HIV Association.
FAU - Gooden, Tiffany E
AU  - Gooden TE
AUID- ORCID: 0000-0002-3905-5477
AD  - Institute for Applied Health Research, University of Birmingham, Birmingham, UK.
FAU - Wang, Jingya
AU  - Wang J
AUID- ORCID: 0000-0003-1498-2693
AD  - Institute for Applied Health Research, University of Birmingham, Birmingham, UK.
FAU - Zemedikun, Dawit T
AU  - Zemedikun DT
AUID- ORCID: 0000-0003-3642-0456
AD  - Institute for Applied Health Research, University of Birmingham, Birmingham, UK.
FAU - Taylor, Stephen
AU  - Taylor S
AUID- ORCID: 0000-0001-5496-6482
AD  - Institute for Applied Health Research, University of Birmingham, Birmingham, UK.
AD  - Department of Infection and Immunology, University Hospitals Birmingham, 
      Birmingham, UK.
FAU - Greenfield, Sheila
AU  - Greenfield S
AUID- ORCID: 0000-0002-8796-4114
AD  - Institute for Applied Health Research, University of Birmingham, Birmingham, UK.
FAU - Manaseki-Holland, Semira
AU  - Manaseki-Holland S
AUID- ORCID: 0000-0001-5827-8855
AD  - Institute for Applied Health Research, University of Birmingham, Birmingham, UK.
FAU - Nirantharakumar, Krishnarajah
AU  - Nirantharakumar K
AUID- ORCID: 0000-0002-6816-1279
AD  - Institute for Applied Health Research, University of Birmingham, Birmingham, UK.
FAU - Thomas, G Neil
AU  - Thomas GN
AUID- ORCID: 0000-0002-2777-1847
AD  - Institute for Applied Health Research, University of Birmingham, Birmingham, UK.
LA  - eng
PT  - Journal Article
DEP - 20220807
PL  - England
TA  - HIV Med
JT  - HIV medicine
JID - 100897392
SB  - IM
CIN - HIV Med. 2023 May;24(5):648-649. PMID: 36782365
MH  - Humans
MH  - Adolescent
MH  - Adult
MH  - *HIV Infections/complications/epidemiology/diagnosis
MH  - *Diabetes Mellitus, Type 2/complications/epidemiology
MH  - Cohort Studies
MH  - *Aging, Premature/epidemiology
MH  - Aging
MH  - *Hypertension/epidemiology
MH  - *Cardiovascular Diseases/epidemiology
MH  - *Renal Insufficiency, Chronic/epidemiology
OTO - NOTNLM
OT  - HIV
OT  - cardiovascular disease
OT  - chronic kidney disease
OT  - diabetes mellitus
OT  - hypertension
EDAT- 2022/08/09 06:00
MHDA- 2023/05/15 06:42
CRDT- 2022/08/08 00:02
PHST- 2022/03/23 00:00 [received]
PHST- 2022/07/14 00:00 [accepted]
PHST- 2023/05/15 06:42 [medline]
PHST- 2022/08/09 06:00 [pubmed]
PHST- 2022/08/08 00:02 [entrez]
AID - 10.1111/hiv.13375 [doi]
PST - ppublish
SO  - HIV Med. 2023 May;24(5):640-647. doi: 10.1111/hiv.13375. Epub 2022 Aug 7.