PMID- 35934900
OWN - NLM
STAT- MEDLINE
DCOM- 20221125
LR  - 20221125
IS  - 2224-9435 (Electronic)
IS  - 1019-9128 (Linking)
VI  - 93
IP  - 2
DP  - 2022 Nov
TI  - Temporally specific adrenocorticotropic hormone reference intervals for horses in 
      South Africa.
PG  - 116-123
LID - 10.36303/JSAVA.001 [doi]
AB  - An endogenous adrenocorticotropic hormone (ACTH) concentration above the 
      reference interval (RI) is commonly used as means for diagnosing equine pituitary 
      pars intermedia dysfunction (PPID). Basal ACTH concentrations are highly 
      dependent on photoperiod and RIs should be month- and location-specific. To date, 
      no ACTH RIs have been specifically established for South Africa. This study aimed 
      to determine geographically and seasonally relevant RIs for equine ACTH in the 
      Gauteng province of South Africa. A longitudinal prospective study was conducted 
      over twelve months to determine ACTH RIs for a representative population of 
      healthy South African horses in the Gauteng province. Eighty clinically healthy 
      horses under 12 years of age were recruited for monthly venous blood sample 
      collection, from July 2019 to June 2020. ACTH was measured using a 
      chemiluminescent assay. RIs were constructed for each month of the year. This 
      South African population showed similar temporal changes in ACTH concentrations 
      to those previously observed in other locations. Upper reference limits were at 
      their lowest in early summer (21.4 pg/ml, 90% CI 20.8-21.7) with a pronounced 
      increase in autumn (60.6 pg/ml, 90% CI 53.1-62.7), and tapered off in winter 
      (22.3 pg/ml, 90% CI 19.9-23.2). The month-specific ACTH RIs generated in this 
      study will improve the accuracy of diagnosis and monitoring of PPID in the local 
      equine population. These results highlighted the previously recommended need for 
      seasonal and location-specific RIs.
FAU - Fisher, D
AU  - Fisher D
AD  - Department of Companion Animal Clinical Studies, Faculty of Veterinary Science, 
      University of Pretoria, South Africa.
FAU - Schliewert, E-C
AU  - Schliewert EC
AD  - Department of Companion Animal Clinical Studies, Faculty of Veterinary Science, 
      University of Pretoria, South Africa.
FAU - Hooijberg, E H
AU  - Hooijberg EH
AD  - Department of Companion Animal Clinical Studies, Faculty of Veterinary Science, 
      University of Pretoria, South Africa.
LA  - eng
PT  - Journal Article
DEP - 20220712
PL  - South Africa
TA  - J S Afr Vet Assoc
JT  - Journal of the South African Veterinary Association
JID - 7503122
RN  - 9002-60-2 (Adrenocorticotropic Hormone)
SB  - IM
MH  - Horses
MH  - Animals
MH  - Adrenocorticotropic Hormone
MH  - South Africa
MH  - Prospective Studies
MH  - *Horse Diseases/diagnosis
MH  - *Pituitary Diseases/diagnosis/veterinary
EDAT- 2022/08/09 06:00
MHDA- 2022/11/26 06:00
CRDT- 2022/08/08 02:32
PHST- 2022/08/09 06:00 [pubmed]
PHST- 2022/11/26 06:00 [medline]
PHST- 2022/08/08 02:32 [entrez]
AID - 10.36303/JSAVA.001 [doi]
PST - ppublish
SO  - J S Afr Vet Assoc. 2022 Nov;93(2):116-123. doi: 10.36303/JSAVA.001. Epub 2022 Jul 
      12.