PMID- 35935481
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220809
IS  - 2296-4185 (Print)
IS  - 2296-4185 (Electronic)
IS  - 2296-4185 (Linking)
VI  - 10
DP  - 2022
TI  - Real-Time MRI Monitoring of GelMA-Based Hydrogel-Loaded Kartogenin for In Situ 
      Cartilage Regeneration.
PG  - 940735
LID - 10.3389/fbioe.2022.940735 [doi]
LID - 940735
AB  - The cartilage has poor ability to mount a sufficient healing response. Herein, 
      kartogenin (KGN), an emerging stable non-protein compound with the ability to 
      recruit bone marrow mesenchyme stem cells (BMSCs) to promote chondrogenic 
      differentiation, was grafted onto dopamine-Fe(III) chelating nanoparticles, 
      followed by involving a gelatin- and dextran-based injectable hydrogel to mimic 
      the extracellular matrix to promote cartilage repair. The in vitro results 
      demonstrated that KGN underwent long-term sustained release behavior and 
      availably promoted the deep migration of BMSC cells in yielding hydrogels. 
      Furthermore, in vivo New Zealand white rabbits' cartilage defect model repairing 
      results showed that cartilage defect obtained significant regeneration post 
      operation in the 12th week, and the defect edge almost disappeared compared to 
      adjacent normal cartilage tissue. Meanwhile, the T(2)-weighted magnetic resonance 
      imaging (MRI) property resulting from dissociative Fe (III) can significantly 
      monitor the degradation degree of the implanted hydrogels in the defect site. 
      This integrated diagnosis and treatment system gives insight into cartilage 
      regeneration.
CI  - Copyright (c) 2022 Zhang, Fang, Zhao, Zhang, Gao, Li, Wang and Xu.
FAU - Zhang, Hanyuan
AU  - Zhang H
AD  - Institute of Intelligent Machines, Chinese Academy of Sciences, Hefei, China.
AD  - Department of Biological Physics, University of Science and Technology of China, 
      Hefei, China.
AD  - Department of Orthopedics, The First Affiliated Hospital of Anhui Medical 
      University, Hefei, China.
FAU - Fang, Weijun
AU  - Fang W
AD  - School of Basic Medical Sciences, Anhui Medical University, Hefei, China.
FAU - Zhao, Tingting
AU  - Zhao T
AD  - School of Basic Medical Sciences, Anhui Medical University, Hefei, China.
FAU - Zhang, Huabing
AU  - Zhang H
AD  - School of Basic Medical Sciences, Anhui Medical University, Hefei, China.
FAU - Gao, Liang
AU  - Gao L
AD  - Hua Tuo Institute of Medical Innovation (HTIMI), Wuhan, China.
AD  - Sino Euro Orthopaedics Network, Berlin, Germany.
FAU - Li, Jingya
AU  - Li J
AD  - Institute of Intelligent Machines, Chinese Academy of Sciences, Hefei, China.
AD  - Department of Biological Physics, University of Science and Technology of China, 
      Hefei, China.
FAU - Wang, Rujing
AU  - Wang R
AD  - Institute of Intelligent Machines, Chinese Academy of Sciences, Hefei, China.
FAU - Xu, Weiping
AU  - Xu W
AD  - Institute of Intelligent Machines, Chinese Academy of Sciences, Hefei, China.
AD  - Department of Biological Physics, University of Science and Technology of China, 
      Hefei, China.
AD  - The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, 
      University of Science and Technology of China, Hefei, China.
LA  - eng
PT  - Journal Article
DEP - 20220722
PL  - Switzerland
TA  - Front Bioeng Biotechnol
JT  - Frontiers in bioengineering and biotechnology
JID - 101632513
PMC - PMC9354815
OTO - NOTNLM
OT  - cartilage regeneration
OT  - dopamine
OT  - hydrogels
OT  - kartogenin
OT  - magnetic resonance imaging (MRI)
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/08/09 06:00
MHDA- 2022/08/09 06:01
PMCR- 2022/01/01
CRDT- 2022/08/08 03:33
PHST- 2022/05/10 00:00 [received]
PHST- 2022/06/06 00:00 [accepted]
PHST- 2022/08/08 03:33 [entrez]
PHST- 2022/08/09 06:00 [pubmed]
PHST- 2022/08/09 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 940735 [pii]
AID - 10.3389/fbioe.2022.940735 [doi]
PST - epublish
SO  - Front Bioeng Biotechnol. 2022 Jul 22;10:940735. doi: 10.3389/fbioe.2022.940735. 
      eCollection 2022.