PMID- 35935931
OWN - NLM
STAT- MEDLINE
DCOM- 20220809
LR  - 20220818
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 13
DP  - 2022
TI  - Case Report: Suspected Case of Brucella-Associated Immune Reconstitution 
      Inflammatory Syndrome.
PG  - 923341
LID - 10.3389/fimmu.2022.923341 [doi]
LID - 923341
AB  - Human brucellosis is one of the most prevalent zoonoses. There are many 
      similarities between the pathogenesis of Mycobacterium tuberculosis (MTB) 
      infection and that of brucellosis. Immune reconstitution inflammatory syndrome 
      (IRIS) may occur during the treatment of MTB infection, but it has not been 
      reported in brucellosis cases thus far. We report the case of a 40-year-old male 
      whose condition initially improved after adequate anti-Brucella therapy. However, 
      3 weeks later, the patient presented with exacerbation of symptoms and 
      development of a paravertebral abscess. After exclusion of other possible causes 
      of clinical deterioration, immune reconstitution inflammatory syndrome (IRIS) 
      with brucellosis was presumed. After supplementation with anti-Brucella treatment 
      with corticosteroids, the abscess disappeared, and the symptoms completely 
      resolved. Our case suggests that it is necessary to be aware of the possible 
      occurrence of IRIS in patients with brucellosis in clinical practice.
CI  - Copyright (c) 2022 Qu, Xu, Niu, Wen, Yang, Wang and Wang.
FAU - Qu, Chunmei
AU  - Qu C
AD  - Department of Infectious Disease, Qilu Hospital, Cheeloo College of Medicine, 
      Shandong University, Jinan, China.
FAU - Xu, Nannan
AU  - Xu N
AD  - Department of Infectious Disease, Qilu Hospital, Cheeloo College of Medicine, 
      Shandong University, Jinan, China.
FAU - Niu, Dehong
AU  - Niu D
AD  - Department of Oncology, the Fifth People's Hospital of Jinan, Jinan, China.
FAU - Wen, Sai
AU  - Wen S
AD  - Department of Infectious Disease, Qilu Hospital, Cheeloo College of Medicine, 
      Shandong University, Jinan, China.
FAU - Yang, Hui
AU  - Yang H
AD  - Department of Infectious Disease, Qilu Hospital, Cheeloo College of Medicine, 
      Shandong University, Jinan, China.
FAU - Wang, Shanshan
AU  - Wang S
AD  - Department of Infectious Disease, Qilu Hospital, Cheeloo College of Medicine, 
      Shandong University, Jinan, China.
FAU - Wang, Gang
AU  - Wang G
AD  - Department of Infectious Disease, Qilu Hospital, Cheeloo College of Medicine, 
      Shandong University, Jinan, China.
LA  - eng
PT  - Case Reports
DEP - 20220722
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
SB  - IM
MH  - Abscess/pathology
MH  - Adult
MH  - *Brucella
MH  - *Brucellosis/complications/diagnosis/drug therapy
MH  - Humans
MH  - *Immune Reconstitution Inflammatory Syndrome/diagnosis/drug therapy/etiology
MH  - Male
MH  - *Mycobacterium tuberculosis
PMC - PMC9353035
OTO - NOTNLM
OT  - IRIS
OT  - case report
OT  - human brucellosis
OT  - immune reconstitution
OT  - infection
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/08/09 06:00
MHDA- 2022/08/10 06:00
PMCR- 2022/01/01
CRDT- 2022/08/08 03:41
PHST- 2022/04/19 00:00 [received]
PHST- 2022/06/24 00:00 [accepted]
PHST- 2022/08/08 03:41 [entrez]
PHST- 2022/08/09 06:00 [pubmed]
PHST- 2022/08/10 06:00 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2022.923341 [doi]
PST - epublish
SO  - Front Immunol. 2022 Jul 22;13:923341. doi: 10.3389/fimmu.2022.923341. eCollection 
      2022.