PMID- 35938041
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220809
IS  - 1664-8021 (Print)
IS  - 1664-8021 (Electronic)
IS  - 1664-8021 (Linking)
VI  - 13
DP  - 2022
TI  - Case Report: Immune Microenvironment and Mutation Features in a Patient With 
      Epstein-Barr Virus Positive Large B-Cell Lymphoma Secondary to Angioimmunoblastic 
      T-Cell Lymphoma.
PG  - 940513
LID - 10.3389/fgene.2022.940513 [doi]
LID - 940513
AB  - On rare occasions, secondary Epstein-Barr virus (EBV)-associated B-cell lymphoma 
      can develop in patients with angioimmunoblastic T-cell lymphoma (AITL). Here, we 
      describe the tumor microenvironment and mutation features of a patient with EBV + 
      large B-cell lymphoma (LBCL) secondary to AITL. He was admitted to hospital due 
      to a 1-year history of fever and enlarged right inguinal lymph nodes. A biopsy of 
      the right inguinal lymph node demonstrated that numerous diffuse medium-sized 
      atypical lymphocytes proliferated, together with increased extrafollicular 
      follicular dendritic cell meshwork, and the lymphocytes expressed CD3, CD4, BCL6, 
      CD10, PD-1, CXCL13, and Ki-67 (75%). Thus, a diagnosis of AITL was made. However, 
      the disease progressed following treatment by CHOP regimen (cyclophosphamide, 
      adriamycin, vincristine, and prednisone). Biopsy showed that most of the cells 
      were positive for CD20 staining and IgH rearrangement. Analysis of 22 kinds of 
      immune cells showed that the numbers of activated NK cells and activated memory T 
      cells increased, while the T-follicular helper population decreased in the 
      transformed sample. In addition, compared with the primary sample, RHOA (G17V) 
      mutation was not detected, while JAK2 and TRIP12 gene mutations were detected in 
      the transformed sample. Overall, we described the immune microenvironment and 
      mutation features of a patient with EBV + LBCL secondary to AITL. This study will 
      help us to understand the mechanisms by which AITL transforms to B-cell lymphoma.
CI  - Copyright (c) 2022 Zhang, Li, Cui, Chen and Liu.
FAU - Zhang, Fen
AU  - Zhang F
AD  - Department of Pathology, Guangdong Provincial People's Hospital, Guangdong 
      Academy of Medical Sciences, Guangzhou, China.
FAU - Li, Wenyu
AU  - Li W
AD  - Department of Pathology, Guangdong Provincial People's Hospital, Guangdong 
      Academy of Medical Sciences, Guangzhou, China.
FAU - Cui, Qian
AU  - Cui Q
AD  - Department of Pathology, Guangdong Provincial People's Hospital, Guangdong 
      Academy of Medical Sciences, Guangzhou, China.
FAU - Chen, Yu
AU  - Chen Y
AD  - Department of Pathology, Guangdong Provincial People's Hospital, Guangdong 
      Academy of Medical Sciences, Guangzhou, China.
FAU - Liu, Yanhui
AU  - Liu Y
AD  - Department of Pathology, Guangdong Provincial People's Hospital, Guangdong 
      Academy of Medical Sciences, Guangzhou, China.
LA  - eng
PT  - Case Reports
DEP - 20220722
PL  - Switzerland
TA  - Front Genet
JT  - Frontiers in genetics
JID - 101560621
PMC - PMC9354849
OTO - NOTNLM
OT  - B-cell lymphoma
OT  - angioimmunoblastic T-cell lymphoma
OT  - case report
OT  - immune microenvironment
OT  - mutations
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/08/09 06:00
MHDA- 2022/08/09 06:01
PMCR- 2022/07/22
CRDT- 2022/08/08 04:12
PHST- 2022/05/10 00:00 [received]
PHST- 2022/06/20 00:00 [accepted]
PHST- 2022/08/08 04:12 [entrez]
PHST- 2022/08/09 06:00 [pubmed]
PHST- 2022/08/09 06:01 [medline]
PHST- 2022/07/22 00:00 [pmc-release]
AID - 940513 [pii]
AID - 10.3389/fgene.2022.940513 [doi]
PST - epublish
SO  - Front Genet. 2022 Jul 22;13:940513. doi: 10.3389/fgene.2022.940513. eCollection 
      2022.