PMID- 35938153
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220809
IS  - 2296-634X (Print)
IS  - 2296-634X (Electronic)
IS  - 2296-634X (Linking)
VI  - 10
DP  - 2022
TI  - The regulation of skin homeostasis, repair and the pathogenesis of skin diseases 
      by spatiotemporal activation of epidermal mTOR signaling.
PG  - 950973
LID - 10.3389/fcell.2022.950973 [doi]
LID - 950973
AB  - The epidermis, the outmost layer of the skin, is a stratified squamous epithelium 
      that protects the body from the external world. The epidermis and its appendages 
      need constantly renew themselves and replace the damaged tissues caused by 
      environmental assaults. The mechanistic target of rapamycin (mTOR) signaling is a 
      central controller of cell growth and metabolism that plays a critical role in 
      development, homeostasis and diseases. Recent findings suggest that mTOR 
      signaling is activated in a spatiotemporal and context-dependent manner in the 
      epidermis, coordinating diverse skin homeostatic processes. Dysregulation of mTOR 
      signaling underlies the pathogenesis of skin diseases, including psoriasis and 
      skin cancer. In this review, we discuss the role of epidermal mTOR signaling 
      activity and function in skin, with a focus on skin barrier formation, hair 
      regeneration, wound repair, as well as skin pathological disorders. We propose 
      that fine-tuned control of mTOR signaling is essential for epidermal structural 
      and functional integrity.
CI  - Copyright (c) 2022 Wang, Cui, Chen and Ding.
FAU - Wang, Juan
AU  - Wang J
AD  - Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of 
      Shanghai University (The Sixth People's Hospital of Nantong), School of Medicine, 
      Shanghai University, Nantong, China.
AD  - Shanghai Engineering Research Center of Organ Repair, School of Medicine, 
      Shanghai University, Shanghai, China.
AD  - School of Medicine, Shanghai University, Shanghai, China.
FAU - Cui, Baiping
AU  - Cui B
AD  - Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of 
      Shanghai University (The Sixth People's Hospital of Nantong), School of Medicine, 
      Shanghai University, Nantong, China.
AD  - Shanghai Engineering Research Center of Organ Repair, School of Medicine, 
      Shanghai University, Shanghai, China.
AD  - School of Medicine, Shanghai University, Shanghai, China.
FAU - Chen, Zhongjian
AU  - Chen Z
AD  - School of Medicine, Shanghai University, Shanghai, China.
AD  - Shanghai Engineering Research Center for External Chinese Medicine, Shanghai, 
      China.
AD  - Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, 
      China.
FAU - Ding, Xiaolei
AU  - Ding X
AD  - Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of 
      Shanghai University (The Sixth People's Hospital of Nantong), School of Medicine, 
      Shanghai University, Nantong, China.
AD  - Shanghai Engineering Research Center of Organ Repair, School of Medicine, 
      Shanghai University, Shanghai, China.
AD  - School of Medicine, Shanghai University, Shanghai, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220722
PL  - Switzerland
TA  - Front Cell Dev Biol
JT  - Frontiers in cell and developmental biology
JID - 101630250
PMC - PMC9355246
OTO - NOTNLM
OT  - epidermis
OT  - keratinocytes
OT  - mTOR
OT  - metabolism
OT  - wound healing
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/08/09 06:00
MHDA- 2022/08/09 06:01
PMCR- 2022/01/01
CRDT- 2022/08/08 04:15
PHST- 2022/05/24 00:00 [received]
PHST- 2022/06/28 00:00 [accepted]
PHST- 2022/08/08 04:15 [entrez]
PHST- 2022/08/09 06:00 [pubmed]
PHST- 2022/08/09 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 950973 [pii]
AID - 10.3389/fcell.2022.950973 [doi]
PST - epublish
SO  - Front Cell Dev Biol. 2022 Jul 22;10:950973. doi: 10.3389/fcell.2022.950973. 
      eCollection 2022.