PMID- 35938405
OWN - NLM
STAT- MEDLINE
DCOM- 20230612
LR  - 20230612
IS  - 1471-1788 (Electronic)
IS  - 1365-1501 (Linking)
VI  - 27
IP  - 2
DP  - 2023 Jun
TI  - Increased NLRP3 inflammasome expression in peripheral blood mononuclear cells of 
      patients with schizophrenia: a case-control study.
PG  - 111-117
LID - 10.1080/13651501.2022.2106245 [doi]
AB  - OBJECTIVE: This study aimed to evaluate the gene expression of the P2X 
      purinoceptor 7 (P2X7R)- nod-like receptor pyrin domain-containing protein 3 
      (NLRP3) signal pathway in peripheral blood mononuclear cells (PBMCs) between 
      schizophrenia (SCZ) patients and healthy controls (HC) to reveal its relationship 
      with clinical variables. METHODS: Thirty-two SCZ patients and 41 healthy controls 
      were included in this study. The Scale for the Assessment of Positive Symptoms 
      (SAPS) and the Scale for the Assessment of Negative Symptoms (SANS), The Global 
      Assessment of Functioning (GAF) scale and the Functioning Assessment Short Test 
      (FAST) scales were applied. P2X7R, NLRP3, IL-1beta and IL-18 gene expression levels 
      were evaluated by real-time polymerase chain reaction in PBMCs. RESULTS: NLRP3, 
      P2RX7, IL-1beta and IL-18 expression levels were significantly higher in PBMCs of 
      SCZ patients than in HC subjects. Negative correlations were found between NLRP3 
      gene expression levels and GAF and FAST scales scores. There was a negative 
      correlation between IL-18 expression levels and the GAF and FAST scales scores 
      and a positive correlation with the SAPS scale scores. CONCLUSIONS: Systemic 
      inflammation is implicated in SCZ pathogenesis, according to our findings, which 
      suggest that the NLRP3 pathway may be involved. The NLRP3 inflammasome may serve 
      as a biomarker for SCZ, and its pharmacological regulation may be a promising 
      treatment approach.Key pointsWe hypothesised that the NLRP3 pathway may 
      contribute to the etiopathogenesis of schizophrenia.NLRP3, IL-1beta and IL-18 mRNA 
      levels were higher in patients with schizophrenia compared to healthy 
      controls.Negative correlations were found between NLRP3 gene expression levels 
      and GAF and FAST scales scores.There was a negative correlation between IL-18 
      expression levels and the GAF and FAST scales scores.The SAPS scale scores and 
      IL-18 expression levels had a positive correlation.Given all these findings, it 
      can be stated that NLRP3 inflammasome may play a role in the pathogenesis and 
      symptoms of schizophrenia.
FAU - Ozdamar Unal, Gulin
AU  - Ozdamar Unal G
AUID- ORCID: 0000-0002-6750-468X
AD  - Department of Psychiatry, Suleyman Demirel University, Faculty of Medicine, 
      Isparta, Turkey.
FAU - Hekimler Ozturk, Kuyas
AU  - Hekimler Ozturk K
AUID- ORCID: 0000-0002-7075-8875
AD  - Department of Medical Genetics, Suleyman Demirel University, Faculty of Medicine, 
      Isparta, Turkey.
FAU - Inci, Huseyin Emre
AU  - Inci HE
AUID- ORCID: 0000-0001-8965-7102
AD  - Department of Psychiatry, Suleyman Demirel University, Faculty of Medicine, 
      Isparta, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20220806
PL  - England
TA  - Int J Psychiatry Clin Pract
JT  - International journal of psychiatry in clinical practice
JID - 9709509
RN  - 0 (Inflammasomes)
RN  - 0 (NLR Family, Pyrin Domain-Containing 3 Protein)
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Humans
MH  - *Inflammasomes/genetics/metabolism
MH  - NLR Family, Pyrin Domain-Containing 3 Protein/genetics/metabolism
MH  - Interleukin-18/metabolism
MH  - Leukocytes, Mononuclear/metabolism/pathology
MH  - Case-Control Studies
MH  - *Schizophrenia/metabolism
OTO - NOTNLM
OT  - IL-18
OT  - IL-1beta
OT  - NLRP3
OT  - P2X7R
OT  - Schizophrenia
OT  - inflammasome
EDAT- 2022/08/09 06:00
MHDA- 2023/06/12 06:42
CRDT- 2022/08/08 05:03
PHST- 2023/06/12 06:42 [medline]
PHST- 2022/08/09 06:00 [pubmed]
PHST- 2022/08/08 05:03 [entrez]
AID - 10.1080/13651501.2022.2106245 [doi]
PST - ppublish
SO  - Int J Psychiatry Clin Pract. 2023 Jun;27(2):111-117. doi: 
      10.1080/13651501.2022.2106245. Epub 2022 Aug 6.