PMID- 35938490
OWN - NLM
STAT- MEDLINE
DCOM- 20220809
LR  - 20220914
IS  - 1752-8984 (Electronic)
IS  - 1479-1641 (Print)
IS  - 1479-1641 (Linking)
VI  - 19
IP  - 4
DP  - 2022 Jul-Aug
TI  - Triglyceride-glucose index is prospectively associated with chronic kidney 
      disease progression in Type 2 diabetes - mediation by pigment epithelium-derived 
      factor.
PG  - 14791641221113784
LID - 10.1177/14791641221113784 [doi]
LID - 14791641221113784
AB  - BACKGROUND: Triglyceride-glucose (TyG) index is a surrogate marker of insulin 
      resistance. Its role in chronic kidney disease (CKD) progression in Type 2 
      Diabetes Mellitus (T2DM) is unclear. We investigated the association between TyG 
      index and CKD progression, and possible mediation of the association by pigment 
      epithelium-derived factor (PEDF). METHODS: This was a prospective study on 1571 
      patients with T2DM. CKD progression was defined as worsening across KDIGO 
      estimated glomerular filtration rate (eGFR) categories with >/=25% reduction from 
      baseline. PEDF was quantitated using enzyme-linked immunosorbent assay method. 
      Cox proportional hazards regression model was used to assess the relationship 
      between TyG index and CKD progression. RESULTS: Over a follow-up period of up to 
      8.6 years (median 4.6 years, IQR 3.0-3.6), 42.7% of subjects had CKD progression. 
      Every unit increase in TyG was associated with hazards of 1.44 (95%CI 1.29-1.61; 
      p < 0.001) in unadjusted analysis and 1.21 (1.06-1.37; p = 0.004) in fully 
      adjusted model. Compared to tertile 1, tertiles 2 and 3 TyG index were positively 
      associated with CKD progression with corresponding hazard ratios HRs 1.24 
      (1.01-1.52; p = 0.037) and 1.37 (1.11-1.68; p = 0.003) in fully adjusted models. 
      PEDF accounted for 36.0% of relationship between TyG index and CKD progression. 
      CONCLUSIONS: Higher TyG index independently predicted CKD progression in T2DM. 
      PEDF mediated the association between TyG index and CKD progression.
FAU - Low, Serena
AU  - Low S
AD  - Diabetes Centre, 609710Admiralty Medical Centre, Singapore.
AD  - Clinical Research Unit, 150819Khoo Teck Puat Hospital, Singapore.
AD  - Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
FAU - Pek, Sharon
AU  - Pek S
AD  - Clinical Research Unit, 150819Khoo Teck Puat Hospital, Singapore.
FAU - Moh, Angela
AU  - Moh A
AD  - Clinical Research Unit, 150819Khoo Teck Puat Hospital, Singapore.
FAU - Ang, Keven
AU  - Ang K
AD  - Clinical Research Unit, 150819Khoo Teck Puat Hospital, Singapore.
FAU - Khoo, Jonathon
AU  - Khoo J
AD  - Clinical Research Unit, 150819Khoo Teck Puat Hospital, Singapore.
FAU - Shao, Yi-Ming
AU  - Shao YM
AD  - Clinical Research Unit, 150819Khoo Teck Puat Hospital, Singapore.
FAU - Tang, Wern E
AU  - Tang WE
AD  - 63707National Healthcare Group Polyclinics, Singapore.
FAU - Lim, Ziliang
AU  - Lim Z
AD  - 63707National Healthcare Group Polyclinics, Singapore.
FAU - Subramaniam, Tavintharan
AU  - Subramaniam T
AUID- ORCID: 0000-0002-5365-8899
AD  - Diabetes Centre, 609710Admiralty Medical Centre, Singapore.
FAU - Sum, Chee F
AU  - Sum CF
AD  - Diabetes Centre, 609710Admiralty Medical Centre, Singapore.
FAU - Lim, Su C
AU  - Lim SC
AD  - Diabetes Centre, 609710Admiralty Medical Centre, Singapore.
AD  - Clinical Research Unit, 150819Khoo Teck Puat Hospital, Singapore.
AD  - Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
AD  - Saw Swee Hock School of Public Health, National University of Singapore, 
      Singapore.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Diab Vasc Dis Res
JT  - Diabetes & vascular disease research
JID - 101234011
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Eye Proteins)
RN  - 0 (Nerve Growth Factors)
RN  - 0 (Serpins)
RN  - 0 (Triglycerides)
RN  - 0 (pigment epithelium-derived factor)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Biomarkers
MH  - Blood Glucose/analysis
MH  - *Diabetes Mellitus, Type 2/complications/diagnosis
MH  - Eye Proteins
MH  - Glucose
MH  - Humans
MH  - Nerve Growth Factors
MH  - Prospective Studies
MH  - *Renal Insufficiency, Chronic/diagnosis
MH  - Risk Factors
MH  - Serpins
MH  - Triglycerides
PMC - PMC9364218
OTO - NOTNLM
OT  - Type 2 diabetes
OT  - chronic kidney disease
OT  - pigment epithelium-derived factor
OT  - triglyceride-glucose index
COIS- Declaration of conflicting interests: The author(s) declared no potential 
      conflicts of interest with respect to the research, authorship, and/or 
      publication of this article.
EDAT- 2022/08/09 06:00
MHDA- 2022/08/10 06:00
PMCR- 2022/08/08
CRDT- 2022/08/08 05:33
PHST- 2022/08/08 05:33 [entrez]
PHST- 2022/08/09 06:00 [pubmed]
PHST- 2022/08/10 06:00 [medline]
PHST- 2022/08/08 00:00 [pmc-release]
AID - 10.1177_14791641221113784 [pii]
AID - 10.1177/14791641221113784 [doi]
PST - ppublish
SO  - Diab Vasc Dis Res. 2022 Jul-Aug;19(4):14791641221113784. doi: 
      10.1177/14791641221113784.