PMID- 35938739
OWN - NLM
STAT- MEDLINE
DCOM- 20230104
LR  - 20230111
IS  - 1360-046X (Electronic)
IS  - 0268-8697 (Linking)
VI  - 36
IP  - 6
DP  - 2022 Dec
TI  - The incidence and prevalence of unruptured intracranial aneurysms in sickle cell 
      disease patients: a systematic review.
PG  - 669-677
LID - 10.1080/02688697.2022.2104217 [doi]
AB  - BACKGROUND: Unruptured Intracranial Aneurysms (UIAs) pose a significant risk of 
      morbidity in the general population and much more so among sickle cell disease 
      (SCD) patients. Meanwhile, the proportion of these patients with UIAs is not 
      established just as the course and characteristics of the aneurysms are not well 
      known. AIM: To estimate the prevalence, incidence and characteristics of UIAs in 
      SCD patients and compare same with the metrics and features in the general 
      population. METHODS: The Data repositories, Medline (PubMed), Embase and Web of 
      science were systematically searched from January 1st, 1990, to July 31st, 2021. 
      Publications that passed an inclusion test were reviewed for data on the 
      incidence and prevalence of UIAs, aneurysm characteristics and outcomes in SCD 
      patients extracted. Findings from the included studies were appraised, using the 
      Methodological Index for Non-randomized studies score (MINORS). The results were 
      descriptively analysed. Given the marked heterogeneity of retrieved data, results 
      were reported as standardized values, including the mean weighted annual 
      incidence rate. RESULTS: 105 SCD patients with 186 UIAs were identified in 10 
      retrospective studies. Mean age ranged from 10.5 to 40.18 across studies with 
      adult (>18 years) predominance. The prevalence of UIAs in SCD was 4.1% (95%CI 3.6 
      and 4.6) incidence rate was 1290.3/100,000 patient-years (95% CI 1018.0-1562.6). 
      Aneurysms tended to be small (60%), anterior (76.1%), multiple (45.7%), and 
      managed conservatively (62%) with mostly good outcomes (95%). The average MINORS 
      score was 9.4 +/- 3.1 for non-comparative studies (n = 8) and 19.5 +/- 0.7 for 
      comparative studies (n = 2). CONCLUSION: UIAs have a definite relationship with 
      SCD, with higher incidence figures relative to the general population. Aneurysmal 
      characteristics although largely similar, tend to be smaller in SCD patients. The 
      low methodological quality of reviewed studies informs the need for well-designed 
      prospective randomized controlled studies to better understand the mechanics of 
      this relationship.
FAU - Essiet, Edidiong
AU  - Essiet E
AD  - Department of Basic and Clinical Neuroscience, Institute of Psychiatry, 
      Psychology and Neuroscience, King's College Denmark Hill Campus, London, UK.
FAU - Shapey, Jonathan
AU  - Shapey J
AD  - Department of Neurosurgery, King's College Hospital NHS Foundation Trust, London, 
      UK.
AD  - School of Biomedical Engineering and Imaging Sciences, King's College London, 
      London, UK.
FAU - Kailaya-Vasan, Ahilan
AU  - Kailaya-Vasan A
AD  - Department of Neurosurgery, King's College Hospital NHS Foundation Trust, London, 
      UK.
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Systematic Review
DEP - 20220808
PL  - England
TA  - Br J Neurosurg
JT  - British journal of neurosurgery
JID - 8800054
SB  - IM
MH  - Adult
MH  - Humans
MH  - Child
MH  - Adolescent
MH  - Young Adult
MH  - *Intracranial Aneurysm/epidemiology
MH  - Retrospective Studies
MH  - Incidence
MH  - Prospective Studies
MH  - Prevalence
MH  - *Anemia, Sickle Cell/complications/epidemiology
MH  - *Aneurysm, Ruptured
MH  - Risk Factors
OTO - NOTNLM
OT  - Unruptured intracranial aneurysm
OT  - incidence
OT  - prevalence
OT  - sickle cell disease
EDAT- 2022/08/09 06:00
MHDA- 2023/01/05 06:00
CRDT- 2022/08/08 08:33
PHST- 2022/08/09 06:00 [pubmed]
PHST- 2023/01/05 06:00 [medline]
PHST- 2022/08/08 08:33 [entrez]
AID - 10.1080/02688697.2022.2104217 [doi]
PST - ppublish
SO  - Br J Neurosurg. 2022 Dec;36(6):669-677. doi: 10.1080/02688697.2022.2104217. Epub 
      2022 Aug 8.